{"id":50284,"date":"2020-08-11T00:00:00","date_gmt":"2020-08-11T00:00:00","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/press\/cu-medicine-researchers-discover-shortened-dna-telomere-length-as-a-useful-biomarker-to-identify-patients-with-diabetes-at-high-risk-of-cardiovascular-disease\/"},"modified":"2020-08-11T00:00:00","modified_gmt":"2020-08-11T00:00:00","slug":"cu-medicine-researchers-discover-shortened-dna-telomere-length-as-a-useful-biomarker-to-identify-patients-with-diabetes-at-high-risk-of-cardiovascular-disease","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/press\/cu-medicine-researchers-discover-shortened-dna-telomere-length-as-a-useful-biomarker-to-identify-patients-with-diabetes-at-high-risk-of-cardiovascular-disease\/","title":{"rendered":"\u4e2d\u5927\u7814\u7a76\u767c\u73fe\u300cDNA\u7aef\u7c92\u9577\u5ea6\u7e2e\u77ed\u300d\u70ba\u6709\u6548\u751f\u7269\u6a19\u8a18\u80fd\u8b58\u5225\u6709\u8f03\u9ad8\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u7684\u7cd6\u5c3f\u75c5\u4eba"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-50284","press","type-press","status-publish","hentry"],"acf":{"title_alt":"","sub_title_alt":"","press_date":"20200811","keep":false,"details":"

\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u806f\u540c\u6fb3\u6d32\u6089\u5c3c\u5927\u5b78\u9032\u884c\u7684\u4e00\u9805\u5927\u578b\u7814\u7a76\u767c\u73fe\uff0c\u300cDNA\u7aef\u7c92\u9577\u5ea6\u7e2e\u77ed\u300d\uff08shortened DNA Telomere Length\uff09\u662f\u6709\u6548\u7684\u751f\u7269\u6a19\u8a18\uff0c\u80fd\u627e\u51fa\u6709\u8f03\u9ad8\u98a8\u96aa\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u76842\u578b\u7cd6\u5c3f\u75c5\u75c5\u4eba\u3002\u4e2d\u5927\u91ab\u5b78\u9662\u5167\u5206\u6ccc\u53ca\u7cd6\u5c3f\u79d1\u5718\u968a\u5206\u6790\u4e86\u903e5,300\u540d2\u578b\u7cd6\u5c3f\u75c5\u75c5\u4eba\u904e\u53bb13\u5e74\u7684\u6578\u64da\uff0c\u4ee5\u8a55\u4f30\u300cDNA\u7aef\u7c92\u9577\u5ea6\u7e2e\u77ed\u300d\u4f5c\u70ba\u751f\u7269\u6a19\u8a18\u7684\u6548\u7528\u3002<\/p>

\u7814\u7a76\u4eba\u54e1\u900f\u904e\u91cf\u5ea6\u75c5\u4eba\u7684\u300c\u767d\u8840\u7403\u7aef\u7c92\u76f8\u5c0d\u9577\u5ea6\u300d\uff08relative Leukocyte Telomere Length\uff09\uff0c\u767c\u73fe\u65bc\u7814\u7a76\u958b\u59cb\u6642\u5df2\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u4ee5\u53ca\u65bc\u8ddf\u9032\u671f\u9593\u51fa\u73fe\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u60a3\u8005\uff0c\u4ed6\u5011\u7684DNA\u7aef\u7c92\u90fd\u6bd4\u6c92\u6709\u5fc3\u8840\u7ba1\u554f\u984c\u7684\u60a3\u8005\u8f03\u77ed\u3002\u6bcf\u7576\u300c\u767d\u8840\u7403\u7aef\u7c92\u76f8\u5c0d\u9577\u5ea6\u300d\u7e2e\u77ed\u4e00\u500b\u55ae\u4f4d\uff0c\u75c5\u4eba\u51fa\u73fe\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98a8\u96aa\u4fbf\u589e\u52a025%\u3002\u7814\u7a76\u7d50\u679c\u5df2\u65bc\u7cd6\u5c3f\u75c5\u79d1\u8457\u540d\u91ab\u5b78\u671f\u520a\u300aD<\/em>iabetes<\/em> Care<\/em>\u300b\u767c\u8868\u3002<\/p>

DNA<\/strong>\u672b\u7aef\u7684\u7aef\u7c92\u7e2e\u77ed\u8207\u7d30\u80de\u8870\u8001\u6709\u95dc<\/strong><\/p>

\u8207\u4e00\u822c\u4eba\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u4eba\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98a8\u96aa\u9ad8\u5169\u500d\u81f3\u56db\u500d\u3002\u504f\u9ad8\u7684\u8840\u7cd6\u3001\u8840\u58d3\u3001\u8840\u8102\uff0c\u4ee5\u53ca\u80a5\u80d6\u3001\u5438\u7159\u3001\u814e\u529f\u80fd\u53d7\u640d\uff0c\u90fd\u662f\u4ee4\u7cd6\u5c3f\u75c5\u4eba\u60a3\u4e0a\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4e3b\u8981\u9ad8\u5371\u56e0\u7d20\u3002\u6839\u64da\u4e2d\u5927\u91ab\u5b78\u9662\u5718\u968a\u9032\u884c\u7684\u7814\u7a76\u986f\u793a\uff0c\u7d0415%\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5728\u672c\u6e2f\u516c\u7acb\u91ab\u9662\u9580\u8a3a\u78ba\u8a3a\u6642\u5df2\u77e5\u60a3\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\uff1b\u53e6\u670915%\u60a3\u8005\u5728\u78ba\u8a3a\u5f8c\u5e73\u57476.7\u5e74\u60a3\u4e0a\u5fc3\u8840\u7ba1\u75be\u75c5\u3002<\/p>

DNA\u5305\u542b\u6bcf\u500b\u500b\u9ad4\u7684\u907a\u50b3\u5bc6\u78bc\uff0c\u6c7a\u5b9a\u4e86\u5176\u7279\u5fb5\u548c\u6240\u50be\u5411\u7684\u5065\u5eb7\u72c0\u6cc1\u3002\u7aef\u7c92\u662f\u6bcf\u689dDNA\u7684\u672b\u7aef\u90e8\u5206\uff0c\u5305\u542b\u7740\u91cd\u8907\u7684\u57fa\u56e0\u7de8\u78bc\uff0c\u6703\u96a8\u7740\u7d30\u80de\u5206\u88c2\u800c\u6108\u7e2e\u6108\u77ed\u3002DNA\u7aef\u7c92\u7e2e\u77ed\u6703\u4ee4\u91cd\u8907\u7684\u57fa\u56e0\u7de8\u78bc\u6d41\u5931\uff0c\u8c61\u5fb5\u7d30\u80de\u8870\u8001\u3002<\/p>

DNA<\/strong>\u7aef\u7c92\u9577\u5ea6\u6bcf\u7e2e\u77ed\u4e00\u500b\u55ae\u4f4d<\/strong> <\/strong>\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u589e<\/strong>25%<\/strong><\/p>

\u7cd6\u5c3f\u75c5\u8207\u9ad4\u5167\u74b0\u5883\u7570\u5e38\u6709\u95dc\uff0c\u589e\u52a0\u4e86\u7d30\u80de\u8001\u5316\u53ca\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98a8\u96aa\u3002\u70ba\u4e86\u9a57\u8b49\u300cDNA\u7aef\u7c92\u9577\u5ea6\u7e2e\u77ed\u300d\u5728\u9810\u6e2c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u7684\u4f5c\u7528\uff0c\u4e2d\u5927\u91ab\u5b78\u9662\u5167\u5206\u6ccc\u53ca\u7cd6\u5c3f\u79d1\u5718\u968a\u7814\u7a76\u4e865,349\u540d\u672c\u6e2f2\u578b\u7cd6\u5c3f\u75c5\u4eba\u7684\u6578\u64da\u3002\u9019\u4e9b\u6578\u64da\u4f86\u81ea\u65bc1995\u5e74\u5efa\u7acb\u7684\u300c\u9999\u6e2f\u7cd6\u5c3f\u75c5\u767b\u8a18\u8cc7\u6599\u5eab\u300d\u3002<\/p>

\u7814\u7a76\u4eba\u54e1\u5f9e\u75c5\u4eba\u767d\u8840\u7403\u63d0\u53d6\u7684DNA\u4e2d\uff0c\u91cf\u5ea6\u300c\u767d\u8840\u7403\u7aef\u7c92\u76f8\u5c0d\u9577\u5ea6\u300d\uff0c\u4e26\u5206\u6790\u75c5\u4eba\u7684\u57fa\u7dda\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53ca\u4ed6\u5011\u57282017\u5e746\u6708\u4e4b\u524d\u7684\u81e8\u5e8a\u60c5\u6cc1\uff0c\u8207\u91cf\u5ea6\u5f97\u51fa\u7684\u7d50\u679c\u6709\u4f55\u95dc\u9023\u3002<\/p>

\u7576\u4e2d808\u540d\u75c5\u4eba\u5728\u78ba\u8a3a\u6642\u5df2\u77e5\u60a3\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u53e6\u5916\u67091,140\u540d\u75c5\u4eba\u572813\u5e74\u8ddf\u9032\u671f\u5167\u60a3\u4e0a\u5fc3\u8840\u7ba1\u75be\u75c5\uff1b\u5118\u7ba1\u4ed6\u5011\u5728\u8ddf\u9032\u671f\u958b\u59cb\u524d\u7684\u98a8\u96aa\u56e0\u7d20\uff0c\u8207\u6c92\u6709\u5fc3\u8840\u7ba1\u554f\u984c\u7684\u75c5\u4eba\u76f8\u82e5\uff0c\u4f46\u4ed6\u5011\u57fa\u7dda\u7684\u300c\u767d\u8840\u7403\u7aef\u7c92\u76f8\u5c0d\u9577\u5ea6\u300d\u5df2\u8f03\u77ed\u3002\u7576\u300c\u767d\u8840\u7403\u7aef\u7c92\u76f8\u5c0d\u9577\u5ea6\u300d\u6bcf\u7e2e\u77ed\u4e00\u500b\u55ae\u4f4d\uff0c\u75c5\u4eba\u60a3\u4e0a\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98a8\u96aa\u4fbf\u6703\u4e0a\u534725%\u3002<\/p>

\u7814\u7a76\u7d50\u679c\u8868\u5217\u5982\u4e0b\uff1a<\/p>

 <\/p><\/td>

\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5
<\/strong>\u7cd6\u5c3f\u75c5\u4eba<\/strong>\u65bc\u57fa\u7dda\u7684
<\/strong>\u300c\u767d\u8840\u7403\u7aef\u7c92\u76f8\u5c0d\u9577\u5ea6\u300d\uff08\u55ae\u4f4d\uff09<\/strong><\/p><\/td>

\u6c92\u6709\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5
<\/strong>\u7cd6\u5c3f\u75c5\u4eba<\/strong>\u65bc\u57fa\u7dda\u7684
<\/strong>\u300c\u767d\u8840\u7403\u7aef\u7c92\u76f8\u5c0d\u9577\u5ea6\u300d\uff08\u55ae\u4f4d\uff09<\/strong><\/p><\/td><\/tr>

\u57fa\u7dda\u6bd4\u8f03
<\/strong>(\u5df2\u77e5\u60a3\u5fc3\u8840\u7ba1\u75c5\u75c5\u4eba\u6578\u76ee: 808\u4eba;
\u6c92\u6709\u60a3\u5fc3\u8840\u7ba1\u75c5\u75c5\u4eba\u6578\u76ee: 4,541\u4eba)<\/p><\/td>

4.3 ± 1.2<\/p><\/td>

4.6 ± 1.2<\/p><\/td><\/tr>

\u8ddf\u9032\u671f\u9593\u6bd4\u8f03
<\/strong>(\u8ddf\u9032\u671f\u9593\u60a3\u4e0a\u5fc3\u8840\u7ba1\u75c5\u75c5\u4eba\u6578\u76ee\uff1a1,140\u4eba;
\u6c92\u6709\u60a3\u5fc3\u8840\u7ba1\u75c5\u75c5\u4eba\u6578\u76ee: 3,401\u4eba)<\/p><\/td>

4.3 ± 1.2<\/p><\/td>

4.7 ± 1.2<\/p><\/td><\/tr><\/tbody><\/table>

(\u5e73\u5747\u503c±\u6a19\u6e96\u5dee)<\/p>

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