{"id":49767,"date":"2018-06-21T00:00:00","date_gmt":"2018-06-21T00:00:00","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/press\/cuhk-led-global-study-sees-improvement-in-overall-survival-in-patients-with-advanced-lung-cancer\/"},"modified":"2018-06-21T00:00:00","modified_gmt":"2018-06-21T00:00:00","slug":"cuhk-led-global-study-sees-improvement-in-overall-survival-in-patients-with-advanced-lung-cancer","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/press\/cuhk-led-global-study-sees-improvement-in-overall-survival-in-patients-with-advanced-lung-cancer\/","title":{"rendered":"\u4e2d\u5927\u8b49\u65b0\u6cbb\u7642\u65b9\u6848\u8f03\u5e38\u898f\u6cbb\u7642\u6709\u6548\u5ef6\u9577\u665a\u671f\u80ba\u764c\u75c5\u4eba\u5b58\u6d3b\u671f"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-49767","press","type-press","status-publish","hentry"],"acf":{"title_alt":"","sub_title_alt":"","press_date":"20180621","keep":false,"details":"<p>\u7531\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u9818\u5c0e\u7684\u6700\u65b0\u570b\u969b\u7814\u7a76\u8b49\u5be6\uff0c\u5e36\u6709\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u57fa\u56e0\u8b8a\u7570\u4e4b\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u7b2c\u4e8c\u4ee3\u6a19\u9776\u6cbb\u7642\u5f8c\uff0c\u6574\u9ad4\u5b58\u6d3b\u671f\uff08Overall Survival\uff09\u8f03\u63a5\u53d7\u5e38\u898f\u6cbb\u7642\u5ef6\u9577\u4e867\u500b\u6708\uff0c\u7576\u4e2d\u8d85\u904e\u4e00\u534a\u60a3\u8005\u66f4\u5b58\u6d3b\u8d85\u904e30\u500b\u6708\u6216\u4ee5\u4e0a\u3002\u662f\u6b21\u7814\u7a76\u70ba\u7b2c\u4e09\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u53cd\u6620\u65b0\u6cbb\u7642\u65b9\u6848\u8f03\u5e38\u898f\u6cbb\u7642\u66f4\u6709\u6548\uff0c\u53ef\u671b\u6210\u70ba\u5e36\u6709EGFR\u57fa\u56e0\u8b8a\u7570\u665a\u671f NSCLC\u75c5\u4eba\u7684\u4e00\u7dda\u6cbb\u7642\u65b0\u6a19\u6e96\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u525b\u65bc\u6b0a\u5a01\u91ab\u5b78\u671f\u520a\u300a<em>Journal of Clinical Oncology<\/em>\u300b\u767c\u8868\uff0c\u4e26\u65bc\u5168\u7403\u6700\u5927\u517c\u6700\u5177\u5f71\u97ff\u529b\u7684\u816b\u7624\u79d1\u7d44\u7e54\u300c\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u300d\u5468\u5e74\u6703\u8b70\u4e2d\u5411\u5168\u7403\u5c08\u5bb6\u767c\u5e03\u3002&nbsp;<\/p><p><strong>\u516b\u6210\u80ba\u764c\u70ba<\/strong><strong>NSCLC<\/strong><strong>\u3000\u7576\u4e2d\u904e\u534a\u80ba\u817a\u764c\u60a3\u8005\u73fe<\/strong><strong>EGFR<\/strong><strong>\u57fa\u56e0\u8b8a\u7570<\/strong>&nbsp;<\/p><p>\u80ba\u764c\u662f\u5168\u7403\u6700\u591a\u4eba\u7f79\u60a3\u7684\u764c\u75c7\uff0c\u6bcf\u5e74\u7d04\u6709160\u842c\u4eba\u6b7b\u65bc\u6b64\u75c5\u3002\u5728\u672c\u6e2f\uff0c\u80ba\u764c\u66f4\u662f\u982d\u865f\u764c\u75c7\u6bba\u624b\uff0c\u4ea6\u662f\u7b2c\u4e8c\u5e38\u898b\u764c\u75c7\uff0c\u6bcf\u5e74\u65b0\u75c7\u903e4,000\u5b97\uff0c\u4e0d\u5c11\u60a3\u8005\u70ba\u5e74\u9752\u5973\u6027\u53ca\u975e\u5438\u7159\u4eba\u58eb\u3002&nbsp;<\/p><p>\u80ba\u764c\u60a3\u8005\u4e2d\u8d85\u904e\u516b\u6210\u70baNSCLC\u3002NSCLC\u4ee5\u80ba\u817a\u764c\u70ba\u4e3b\uff0c\u7576\u4e2d\u80ba\u817a\u764c\u75c5\u4eba\u6709\u63a5\u8fd1\u4e00\u534a\u662f\u56e0\u70ba\u8eab\u9ad4\u51fa\u73feEGFR\u57fa\u56e0\u8b8a\u7570\u800c\u81f4\u75c5\u7684\u3002&nbsp;<\/p><p>\u4e2d\u5927\u91ab\u5b78\u9662\u816b\u7624\u5b78\u7cfb\u7cfb\u4e3b\u4efb\u517c\u674e\u6a39\u82ac\u91ab\u5b78\u57fa\u91d1\u816b\u7624\u5b78\u6559\u6388<strong>\u83ab\u6a39\u9326<\/strong>\u6559\u6388\u65e9\u65bc2009\u5e74\u78ba\u7acb\u53e3\u670d\u6a19\u9776\u85e5Gefitinib\u70baEGFR\u57fa\u56e0\u8b8a\u7570\u7684\u4e00\u7dda\u65b9\u6848\u3002\u5728\u904e\u53bb\u5341\u5e74\uff0c\u96a8\u8457\u91ab\u5b78\u767c\u5c55\u4e00\u65e5\u5343\u91cc\uff0c\u5df2\u51fa\u73fe\u65b0\u578b\u7684\u80ba\u764c\u6a19\u9776\u6cbb\u7642\u3002&nbsp;<\/p><p><strong>\u65b0\u6cbb\u7642\u5ef6\u9577\u665a\u671f\u80ba\u764c\u60a3\u8005\u5b58\u6d3b\u671f<\/strong><strong>7<\/strong><strong>\u500b\u6708<\/strong><\/p><p>\u70ba\u4e86\u89e3\u7b2c\u4e8c\u4ee3\u6a19\u9776\u85e5Dacomitinib\u8207\u5e38\u898f\u6cbb\u7642\u6240\u7528\u7684Gefitinib\u5c0dEGFR\u57fa\u56e0\u8b8a\u7570\u665a\u671fNSCLC\u75c5\u4eba\u7684\u7642\u6548\uff0c\u83ab\u6a39\u9326\u6559\u6388\u7387\u9818\u5168\u740371\u6240\u91ab\u7642\u4e2d\u5fc3\u548c\u5927\u5b78\u91ab\u9662\uff0c\u9032\u884c\u4e00\u9805\u540d\u70ba\u300cARCHER 1050\u300d\u7684\u7b2c\u4e09\u671f\uff08Phase 3\uff09\u81e8\u5e8a\u7814\u7a76\u3002&nbsp;<\/p><p>\u4e0a\u968e\u6bb5\u7684\u7814\u7a76\u5df2\u8b49\u5be6\uff0c\u75c5\u4eba\u5728\u63a5\u53d7\u7b2c\u4e8c\u4ee3\u6a19\u9776\u85e5\u6cbb\u7642\u5f8c\uff0c\u300c\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u300d\uff08progression-free survival\uff09\u8d85\u904e1\u5e74\u4ee5\u4e0a\uff0c\u8f03\u5e38\u898f\u6cbb\u7642\u95776\u500b\u6708\u3002<\/p><p>\u4eca\u6b21\u767c\u8868\u7684\u6700\u65b0\u7814\u7a76\u7d50\u679c\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u7b2c\u4e8c\u4ee3\u6a19\u9776\u85e5\u80fd\u5c07\u60a3\u8005\u6574\u9ad4\u5b58\u6d3b\u671f\uff08overall survival\uff09 \u5ef6\u9577\u3002452\u540d\u88ab\u78ba\u8a3aEGFR\u57fa\u56e0\u8b8a\u7570\u7684\u665a\u671fNSCLC\u75c5\u4eba\u53c3\u8207\u7814\u7a76\uff0c\u7576\u4e2d\u8fd1\u516b\u6210\u70ba\u4e9e\u6d32\u4eba\u3002\u75c5\u4eba\u88ab\u5206\u6210\u5169\u7d44\uff0c\u5206\u5225\u63a5\u53d7\u7b2c\u4e8c\u4ee3\u6a19\u9776\u85e5Dacomitinib\u548c\u5e38\u898f\u7684Gefitinib\u6cbb\u7642\u3002\u7d50\u679c\u767c\u73fe\uff0c\u63a5\u53d7\u65b0\u85e5\u6cbb\u7642\u7684\u60a3\u8005\uff0c\u6574\u9ad4\u5b58\u6d3b\u671f\u63a5\u8fd1\u4e09\u5e74\uff0c\u8f03\u5e38\u898f\u6cbb\u7642\u591a\u4e867\u500b\u6708\uff0c\u800c\u4e14\u904e\u534a\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u764230\u500b\u6708\u5f8c\u4ecd\u7136\u5b58\u6d3b\u3002<br \/><br \/>\u4e0b\u8868\u7d9c\u5408\u7b2c\u4e8c\u4ee3\u6a19\u9776\u85e5\u548c\u5e38\u898f\u6a19\u9776\u85e5\u7684\u7642\u6548\u6bd4\u8f03\uff1a<strong><\/strong><\/p><table border=\"1\" cellspacing=\"0\" cellpadding=\"0\"><tbody><tr><td valign=\"top\" width=\"225\"><p>&nbsp;<\/p><\/td><td valign=\"top\" width=\"168\"><p align=\"center\"><strong>\u7b2c\u4e8c\u4ee3\u6a19\u9776\u85e5 <\/strong><strong>Dacomitinib<br \/><\/strong><strong>\uff08<\/strong><strong>227<\/strong><strong>\u4eba\uff09<\/strong><strong><\/strong><\/p><\/td><td valign=\"top\" width=\"165\"><p align=\"center\"><strong>\u5e38\u898f\u6a19\u9776\u85e5 <\/strong><strong>Gefitinib<br \/><\/strong><strong>\uff08<\/strong><strong>225<\/strong><strong>\u4eba\uff09<\/strong><strong><\/strong><\/p><\/td><\/tr><tr><td valign=\"top\" width=\"225\"><p><strong>\u6574\u9ad4\u5b58\u6d3b\u671f\uff08\u4e2d\u4f4d\u6578\uff09<\/strong><strong><\/strong><\/p><\/td><td valign=\"top\" width=\"168\"><p align=\"center\">34\u500b\u6708<\/p><\/td><td valign=\"top\" width=\"165\"><p align=\"center\">27\u500b\u6708<\/p><\/td><\/tr><tr><td valign=\"top\" width=\"225\"><p><strong>\u6574\u9ad4\u5b58\u6d3b\u7387\uff08\u63a5\u53d7\u6cbb\u7642<\/strong><strong>30<\/strong><strong>\u500b\u6708\u5f8c\uff09<\/strong><strong><\/strong><\/p><\/td><td valign=\"top\" width=\"168\"><p align=\"center\">56%<\/p><\/td><td valign=\"top\" width=\"165\"><p align=\"center\">46%<\/p><\/td><\/tr><tr><td valign=\"top\" width=\"225\"><p><strong>\u764c\u7d30\u80de\u64f4\u6563\u6216\u8f49\u79fb\u81f3\u8166\u90e8<\/strong><strong><\/strong><\/p><\/td><td valign=\"top\" width=\"168\"><p align=\"center\">1\u4eba<\/p><\/td><td valign=\"top\" width=\"165\"><p align=\"center\">11\u4eba<\/p><\/td><\/tr><\/tbody><\/table><p>\u5728\u65b0\u85e5\u7d44\u4e2d\uff0c\u9700\u8981\u9032\u884c\u8ddf\u9032\u5316\u7642\u7684\u60a3\u8005\u6578\u76ee\u4e5f\u8f03\u5e38\u898f\u7d44\u5c11\u8fd1\u4e00\u6210\u3002&nbsp;<\/p><p><strong>\u7b2c\u4e09\u671f\u81e8\u5e8a\u7814\u7a76\u986f\u793a\u65b0\u6cbb\u7642\u65b9\u6848\u8f03\u5e38\u898f\u6cbb\u7642\u512a\u52dd<\/strong>&nbsp;<\/p><p><strong>\u83ab\u6a39\u9326\u6559\u6388<\/strong>\u5728\u672c\u6708\u521d\u8209\u884c\u7684\u7b2c54\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5468\u5e74\u6703\u8b70\uff0c\u767c\u5e03\u4e0a\u8ff0\u7814\u7a76\u7d50\u679c\u6642\u6307\u51fa\uff1a\u300c\u6574\u9ad4\u5b58\u6d3b\u671f\u662f\u8a55\u4f30\u65b0\u764c\u75c7\u6cbb\u7642\u6210\u6548\u7684\u91cd\u8981\u6307\u6a19\u3002\u4eca\u6b21\u7814\u7a76\u5225\u5177\u610f\u7fa9\u7684\u5730\u65b9\uff0c\u5728\u65bc\u9019\u662f\u9996\u500b\u7b2c\u4e09\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u96a8\u6a5f\u6bd4\u8f03\u5169\u6b3e\u91dd\u5c0dEGFR\u7684\u6297\u764c\u85e5\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u6642\uff0c\u7d50\u679c\u767c\u73fe\u80fd\u6709\u6548\u5ef6\u9577\u75c5\u4eba\u7684\u6574\u9ad4\u5b58\u6d3b\u671f\u3002\u65b0\u6cbb\u7642\u65b9\u6848\u4e0d\u8ad6\u5728\u5ef6\u9577\u75c5\u4eba\u7684\u300e\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u300f\u53ca\u300e\u6574\u9ad4\u5b58\u6d3b\u671f\u300f\u90fd\u8f03\u512a\u52dd\u3002\u6211\u5011\u671f\u671b\u662f\u6b21\u7814\u7a76\u7d50\u679c\u53ef\u70ba\u5e36\u6709EGFR\u57fa\u56e0\u8b8a\u7570\u7684\u665a\u671fNSCLC\u75c5\u4eba\u63d0\u4f9b\u591a\u500b\u4e00\u7dda\u6cbb\u7642\u7684\u9078\u64c7\uff0c\u53ef\u70ba\u4ed6\u5011\u9032\u884c\u66f4\u9069\u5207\u7684\u6cbb\u7642\u3002\u300d<\/p><p>\u83ab\u6559\u6388\u88dc\u5145\uff1a\u300c\u65b0\u6cbb\u7642\u65b9\u6848\u96d6\u7136\u6709\u4e0d\u932f\u7684\u7642\u6548\uff0c\u4f46\u6211\u5011\u4e5f\u8981\u7559\u610f\u5b83\u7684\u526f\u4f5c\u7528\uff0c\u6700\u5e38\u898b\u662f\u8178\u80c3\u4e0d\u9069\u3002\u7576\u4e2d\u67098\u6210\u7684\u60a3\u8005\u5728\u670d\u7528\u7b2c\u4e8c\u4ee3\u6a19\u9776\u85e5\u5f8c\u51fa\u73fe\u809a\u7009\u7684\u60c5\u6cc1\uff0c\u56b4\u91cd\u8005\u66f4\u9700\u8981\u505c\u6b62\u670d\u7528\u6b64\u85e5\u7269\u3002\u300d<\/p><p><strong>\u4e9e\u6d32\u7814\u7a76\u7e7c\u7e8c\u5f71\u97ff\u5168\u7403\u80ba\u764c\u6cbb\u7642\u65b9\u5411<\/strong>&nbsp;<\/p><p>\u83ab\u6559\u6388\u65bc2009\u5e74\u78ba\u7acbEGFR\u57fa\u56e0\u8b8a\u7570\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\uff0c\u4e26\u65bc2016\u5e74\u5c31\u63a5\u53d7\u4e00\u7dda\u6a19\u9776\u6cbb\u7642\u5f8c\u518d\u51fa\u73fe\u57fa\u56e0\u7a81\u8b8a\u53ca\u6297\u85e5\u6027\u7684\u75c5\u4eba\uff0c\u63d0\u5021\u5d84\u65b0\u6cbb\u7642\u6a21\u5f0f\u3002\u6b64\u9805\u7814\u7a76\u65bc2017\u5e74\u7372\u5168\u7403\u9802\u5c16\u91ab\u5b78\u671f\u520a\u300a\u65b0\u82f1\u502b\u91ab\u5b78\u96dc\u8a8c\u300b\uff08<em>The New England Journal of 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