\u6709\u7814\u7a76\u6307\u6cbb\u7642\u963f\u8332\u6d77\u9ed8\u75c7\uff08\u4fd7\u7a31\u300c\u8001\u4eba\u8a8d\u77e5\u969c\u7919\u75c7\u300d\uff09\u9808\u5728\u60a3\u8005\u767c\u75c5\u521d\u671f\u958b\u59cb\u624d\u6709\u6548\uff0c\u7136\u800c\uff0c\u73fe\u6642\u672c\u6e2f\u80fd\u5920\u8a3a\u65b7\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u6aa2\u6e2c\u4e26\u4e0d\u666e\u904d\u3002\u70ba\u4f7f\u7be9\u67e5\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u6aa2\u6e2c\u66f4\u5feb\u6377\u3001\u7d93\u6fdf\u548c\u666e\u53ca\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u5728\u7a2e\u5b50\u57fa\u91d1\u6709\u9650\u516c\u53f8\u53ca\u91ab\u7642\u885e\u751f\u7814\u7a76\u57fa\u91d1\uff08\u98df\u7269\u53ca\u885e\u751f\u5c40\uff09\u652f\u6301\u4e0b\uff0c\u8207\u990a\u548c\u91ab\u9662\u5408\u4f5c\u5c55\u958b\u300c\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7\u7be9\u67e5\u7814\u7a76\u300d\uff08SEEDS Study\uff09\uff0c\u4ee5\u63a2\u8a0e\u83ef\u4eba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u751f\u7269\u6a19\u8a18 (biomarkers) \u4f5c\u8a8d\u77e5\u969c\u7919\u75c7\u6aa2\u6e2c\u3002 <\/p>
\u6108\u65e9\u6aa2\u6e2c \u6108\u65e9\u4ecb\u5165\u8a8d\u77e5\u969c\u7919\u75c7\u6cbb\u7642<\/strong> <\/p> \u65e9\u5e74\u4e2d\u5927\u7814\u7a76\u767c\u73fe\uff0c\u672c\u6e2f70\u6b72\u4ee5\u4e0a\u9577\u8005\u6bcf10\u4eba\u4fbf\u67091\u4f4d\u8a8d\u77e5\u969c\u7919\u60a3\u8005\uff0c\u800c85\u6b72\u4ee5\u4e0a\u5247\u6bcf3\u4eba\u4fbf\u67091\u4f4d\u60a3\u8005\u3002\u60a3\u8005\u4e2d\u53ea\u6709\u5341\u5206\u4e00\u4eba\u66fe\u7d93\u6c42\u91ab\u6216\u5df2\u78ba\u8a3a\u3002 <\/p> \u8a8d\u77e5\u969c\u7919\u75c7\u60a3\u8005\u8d85\u904e\u4e00\u534a\u6210\u56e0\u662f\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheimer’s disease\uff09\uff0c\u4ed6\u5011\u7684\u8166\u90e8\u6703\u7a4d\u805a\u4e0d\u6b63\u5e38\u7684\u7269\u8cea–\u6fb1\u7c89\u72c0\u86cb\u767d\u53ca\u795e\u7d93\u7e96\u7dad\u7e8f\u7d50\uff0c\u5c0e\u81f4\u8166\u7d30\u80de\u9010\u6f38\u6b7b\u4ea1\uff0c\u5f9e\u800c\u5f15\u81f4\u6f38\u9032\u5f0f\u7684\u8a8d\u77e5\u9000\u6b65\u3002 <\/p> \u4e2d\u5927\u91ab\u5b78\u9662\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u8166\u795e\u7d93\u79d1\u4e3b\u4efb\u83ab\u4ef2\u68e0\u6559\u6388<\/strong>\u8868\u793a\uff1a\u300c\u6709\u7814\u7a76\u6307\uff0c\u6291\u5236\u6fb1\u7c89\u72c0\u86cb\u767d\u7684\u6cbb\u7642\u6216\u80fd\u9632\u6b62\u8a8d\u77e5\u80fd\u529b\u9032\u4e00\u6b65\u4e0b\u964d\uff0c\u95dc\u9375\u5728\u65bc\u60a3\u8005\u9808\u5728\u5f88\u65e9\u671f\uff0c\u4f8b\u5982\u5728\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919 (MCI) \u968e\u6bb5\u63a5\u53d7\u6cbb\u7642\u624d\u6709\u6548\u3002\u6108\u65e9\u767c\u73fe\uff0c\u6211\u5011\u4fbf\u53ef\u4ee5\u6108\u65e9\u4ecb\u5165\u6cbb\u7642\uff0c\u5f9e\u800c\u6e1b\u6162\u751a\u81f3\u904f\u6b62\u75c5\u60c5\u7e7c\u7e8c\u60e1\u5316\uff0c\u6e1b\u8f15\u75c5\u4eba\u53ca\u5bb6\u5c6c\u7684\u75db\u82e6\u3002\u300d <\/p> \u5c0b\u627e\u83ef\u4eba\u5c08\u5c6c\u7684\u751f\u7269\u6a19\u8a18 \u958b\u62d3\u65b0\u6aa2\u6e2c\u65b9\u6cd5<\/strong> <\/p> \u73fe\u6642\uff0c\u8a3a\u65b7\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7\u9700\u8981\u4f7f\u7528\u6fb1\u7c89\u72c0\u86cb\u767d\uff0d\u6b63\u96fb\u5b50\u8166\u6383\u63cf (amyloid-PET scan) \uff0c\u6216\u901a\u904e\u8170\u690e\u7a7f\u523a\u63d0\u53d6\u8166\u810a\u6db2\u9032\u884c\u6aa2\u6e2c\u3002\u4e0d\u904e\u6b64\u7b49\u6aa2\u6e2c\u65b9\u6cd5\u4e0d\u666e\u53ca\u4e26\u5177\u5165\u4fb5\u6027\u3002\u6709\u898b\u53ca\u6b64\uff0c\u4e2d\u5927\u8166\u795e\u7d93\u79d1\u5718\u968a\u5e0c\u671b\u900f\u904e\u958b\u5c55\u300c\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7\u7be9\u67e5\u7814\u7a76\u300d(SEEDS Study) \uff0c\u901a\u904e\u8996\u7db2\u819c\u5f71\u50cf\u6280\u8853\u53ca\u8840\u6db2\u6e2c\u8a66\uff0c\u5c0b\u627e\u53ca\u78ba\u8a8d\u4ee5\u7be9\u67e5\u83ef\u4eba\u7368\u6709\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u751f\u7269\u6a19\u8a18\uff0c\u4ee5\u958b\u62d3\u65b0\u7684\u6aa2\u6e2c\u65b9\u6cd5\u3002 <\/p> \u4e2d\u5927\u91ab\u5b78\u9662\u773c\u79d1\u53ca\u8996\u89ba\u79d1\u5b78\u5b78\u7cfb\u52a9\u7406\u6559\u6388\u5f35\u8277\u857e\u535a\u58eb<\/strong>\u89e3\u91cb\uff1a\u300c\u8996\u7db2\u819c\u662f\u4e2d\u6a1e\u795e\u7d93\u7684\u5ef6\u4f38\uff0c\u8b93\u6211\u5011\u53ef\u900f\u904e\u773c\u775b\u9019\u500b\u300e\u7a97\u53e3\u300f\u53bb\u89c0\u5bdf\u8166\u5167\u8840\u7ba1\u548c\u795e\u7d93\u9000\u5316\u7684\u640d\u5bb3\u3002\u6211\u5011\u5df2\u6210\u529f\u7814\u767c\u53ca\u61c9\u7528\u4e0d\u5177\u5165\u4fb5\u6027\u7684\u8996\u7db2\u819c\u5f71\u50cf\u6280\u8853\u4f86\u7372\u53d6\u751f\u7269\u6a19\u8a18\uff0c\u5354\u52a9\u4e86\u89e3\u773c\u548c\u8166\u5167\u7684\u8840\u7ba1\u53ca\u795e\u7d93\u75c5\u8b8a\u3002\u800c\u900f\u904e\u662f\u6b21SEEDS\u7814\u7a76\uff0c\u6211\u5011\u5e0c\u671b\u66f4\u9032\u4e00\u6b65\u4e86\u89e3\u65e9\u671f\u8840\u7ba1\u529f\u80fd\u969c\u7919\u53ca\u8166\u795e\u7d93\u640d\u5bb3\u5c0d\u8a8d\u77e5\u969c\u7919\u75c7\u7684\u75c5\u7406\u5f71\u97ff\uff0c\u4ee5\u52a9\u7be9\u67e5\u963f\u8332\u6d77\u9ed8\u75c7\u53ca\u65e9\u671f\u8a8d\u77e5\u969c\u7919\u75c7\u60a3\u8005\u3002\u300d <\/p> \u300c\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7\u7be9\u67e5\u7814\u7a76\u300d\u73fe\u62db\u52df100\u4f4d\u5e74\u9f61\u4ecb\u4e4e50\u6b72\u81f380\u6b72\u4eba\u58eb\u53c3\u8207\uff0c\u7576\u4e2d\u5305\u62ec\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919\u60a3\u8005\u3001\u56b4\u91cd\u963f\u8332\u6d77\u9ed8\u8a8d\u77e5\u969c\u7919\u75c7\u60a3\u8005\u53ca\u8a8d\u77e5\u529f\u80fd\u6b63\u5e38\u4eba\u58eb\u3002\u53c3\u52a0\u8005\u5c07\u9032\u884c\u5404\u9805\u81e8\u5e8a\u6aa2\u6e2c\uff0c\u5305\u62ec\u7531\u4e2d\u5927\u91ab\u5b78\u9662\u7814\u7a76\u5718\u968a\u9032\u884c\u7684\u8a8d\u77e5\u80fd\u529b\u6e2c\u8a66\u3001\u8840\u6db2\u6e2c\u8a66\u3001\u8166\u90e8\u78c1\u529b\u5171\u632f\u6383\u63cf\u548c\u8996\u7db2\u819c\u5f71\u50cf\u6aa2\u67e5\uff0c\u4ee5\u53ca\u65bc\u990a\u548c\u91ab\u9662\u9032\u884c\u6fb1\u7c89\u72c0\u86cb\u767d\uff0d\u6b63\u96fb\u5b50\u8166\u6383\u63cf\u3002<\/p> \u4f5c\u70ba\u9996\u4f4d\u53c3\u8207\u6b64\u7814\u7a76\u8a08\u5283\u7684\u75c5\u4eba\u5bb6\u5c6c\uff0c\u9999\u6e2f\u85dd\u4eba\u9ec3\u53c8\u5357\u5148\u751f<\/strong>\u8868\u793a\uff1a\u300c\u91ab\u5b78\u7814\u7a76\u5728\u5c0d\u6297\u75be\u75c5\u6642\u767c\u63ee\u6975\u91cd\u8981\u4f5c\u7528\uff0c\u6240\u4ee5\u6211\u8b93\u7236\u89aa\u53c3\u8207\u7814\u7a76\u3002\u96d6\u7136\u4ed6\u73fe\u5728\u662f\u8a8d\u77e5\u969c\u7919\u75c7\u60a3\u8005\uff0c\u4f46\u4ecd\u6709\u6a5f\u6703\u70ba\u6cbb\u7642\u9019\u75c5\u51fa\u4e00\u5206\u529b\u3002\u6211\u4e5f\u5e0c\u671b\u5176\u4ed6\u60a3\u8005\u3001\u5bb6\u5c6c\u4ee5\u53ca\u516c\u773e\u5c0d\u6b64\u75c7\u6709\u66f4\u591a\u8a8d\u8b58\uff0c\u4e26\u61c2\u5f97\u9810\u9632\uff0c\u6e1b\u4f4e\u65e5\u5f8c\u60a3\u75c5\u7684\u6a5f\u6703\u3002\u300d <\/p> \u7814\u7a76\u5354\u4f5c\u55ae\u4f4d\u7a2e\u5b50\u57fa\u91d1\u6709\u9650\u516c\u53f8\u8463\u4e8b\u7562\u8302\u68ee\u5148\u751f<\/strong>\u8868\u793a\uff1a\u300c\u7a2e\u5b50\u57fa\u91d1\u4e09\u5e74\u524d\u8cc7\u52a9\u4e2d\u5927\u8166\u795e\u7d93\u79d1\u5718\u968a\u6210\u7acb\u300e\u65e9\u767c\u6027\u8a8d\u77e5\u969c\u7919\u75c7\u300f\u7814\u7a76\u767b\u8a18\u518a\uff0c\u6210\u679c\u4ee4\u4eba\u9f13\u821e\u3002\u4eca\u5e74\u5f97\u77e5\u4ed6\u5011\u8a08\u5283\u9032\u884c\u65e9\u671f\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u7814\u7a76\uff0c\u6c7a\u5b9a\u518d\u6b21\u652f\u6301\uff0c\u8b93\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u8a3a\u65b7\u8b8a\u5f97\u6e96\u78ba\u4e26\u666e\u53ca\uff0c\u8b93\u60a3\u8005\u53ca\u65e9\u5f97\u5230\u9069\u5207\u7684\u6cbb\u7642\u3002\u300d <\/p> \u5021\u8b70\u300c\u5065\u5230\u8166\u30fb\u6d3b\u5230\u8001\u300d \u547c\u7c72\u5927\u773e\u7ba1\u7406\u8166\u5065\u5eb7<\/strong> <\/p> \u5168\u7403\u6b0a\u5a01\u91ab\u5b78\u671f\u520a\u300a\u523a\u91dd\u300b\u65bc\u4e0a\u6708\u767c\u8868\u7814\u7a76\uff0c\u6307\u767e\u5206\u4e4b\u4e09\u5341\u7684\u8a8d\u77e5\u969c\u7919\u75c7\u5176\u5be6\u53ef\u4ee5\u9810\u9632\u3002\u9664\u4e86\u9810\u9632\u6027\u7814\u7a76\uff0c\u6559\u80b2\u4ea6\u662f\u4e2d\u5927\u8166\u795e\u7d93\u79d1\u5718\u968a\u7684\u5de5\u4f5c\u91cd\u9ede\uff0c\u5718\u968a\u5021\u8b70\u300c\u5065\u5230\u8166\u30fb\u6d3b\u5230\u8001\u300d\u6559\u80b2\u53e3\u865f\uff0c\u63d0\u793a\u516c\u773e\u591a\u6ce8\u610f\u300c\u8166\u5065\u5eb7\u300d\u3002 <\/p> 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