2013\u5e74\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b78\u53ca\u91ab\u5b78\u734e\u5f97\u4e3b\u5091\u5f17\u7406\uff0e\u970d\u723e\u6559\u6388\uff08Prof. Jeffrey Hall\uff09\u3001\u9081\u514b\u723e\uff0e\u7f85\u65af\u5df4\u6b8a\uff08Prof. Michael Rosbash\uff09\u53ca\u9081\u514b\u723e\uff0e\u694a\u6559\u6388\uff08Prof. Michael Young\uff09\u6628\u5929\uff089\u670824\u65e5\uff09\u89aa\u81e8\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u9038\u592b\u66f8\u9662\uff0c\u5206\u5225\u4ee5\u300c\u4eba\u7686\u5c0b\u5922\u300d\uff08Everybody’s a Dreamer, and Everybody’s a Star \uff09\u3001\u300c\u665d\u591c\u7bc0\u5f8b\u7684\u5faa\u74b0\u63a7\u5236:\u56de\u671b\u5eff\u8f09\u8207\u5c55\u671b\u672a\u4f86\u300d\uff08The Circadian Feedback Loop: Twenty Years and Counting\uff09\u53ca\u300c\u63a7\u5236\u7761\u7720\u53ca\u665d\u591c\u7bc0\u5f8b\u7684\u57fa\u56e0\u300d\uff08Genes Controlling Sleep and Circadian Rhythms\uff09\u70ba\u984c\u6f14\u8b1b\uff0c\u5438\u5f15\u8fd1420\u540d\u4e2d\u5927\u53ca\u672c\u5730\u5176\u4ed6\u5927\u5b78\u548c\u4e2d\u5b78\u7684\u5e2b\u751f\uff0c\u4ee5\u53ca\u76f8\u95dc\u5c08\u5bb6\u5b78\u8005\u51fa\u5e2d\u3002 <\/p>
2013\u5e74\u5ea6\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b78\u8207\u91ab\u5b78\u734e\u9812\u4e88\u7dec\u56e0\u5dde\u5927\u5b78\u5ba2\u5e2d\u6559\u6388\u5091\u5f17\u7406\uff0e\u970d\u723e (Jeffrey C Hall)\u3001\u5e03\u862d\u6234\u65af\u5927\u5b78\u751f\u7269\u5b78\u6559\u6388\u66a8\u970d\u83ef\u5fb7\u4f11\u65af\u91ab\u5b78\u7814\u7a76\u6240 (HHMI) \u7814\u7a76\u54e1\u9081\u514b\u723e\uff0e\u7f85\u65af\u5df4\u6b8a (Michael Rosbash)\u3001\u53ca\u6d1b\u514b\u83f2\u52d2\u5927\u5b78\u5b78\u8853\u4e8b\u52d9\u526f\u6821\u9577\u517c\u6559\u6388\u9081\u514b\u723e\uff0e\u694a (Michael W Young)\uff0c\u4ee5\u8868\u5f70\u4ed6\u5011\u767c\u73fe\u751f\u7269\u665d\u591c\u7bc0\u5f8b\u7684\u5206\u5b50\u6a5f\u5236\u3002 <\/p>
\u6240\u6709\u751f\u7269\u90fd\u6709\u4e00\u5b9a\u7684\u7bc0\u5f8b\uff0c\u4eba\u985e\u665a\u9593\u51fa\u73fe\u7761\u610f\u3001\u98db\u884c\u6642\u5dee\u5e36\u4f86\u56f0\u64fe\u3001\u82b1\u6735\u665d\u958b\u591c\u5408\uff0c\u9019\u90fd\u662f\u719f\u6089\u7684\u73fe\u8c61\u3002\u9019\u4e9b\u665d\u591c (circadian\u62c9\u4e01\u6587\u300c\u65e5\u5e38\u300d\u7684\u610f\u601d) \u7684\u7bc0\u5f8b\u96d6\u7136\u8033\u719f\u80fd\u8a73\uff0c\u4f46\u751f\u7269\u6642\u9418\u7684\u672c\u8cea\u4e00\u76f4\u662f\u6666\u6f80\u7684\uff0c\u76f4\u81f3\u5df2\u6545\u7684\u897f\u6469\uff0e\u672c\u6fa4 (Seymour Benzer) \u85c9\u8457\u7814\u7a76\u679c\u8805\uff0c\u767c\u73fe\u4e86\u4e00\u500b\u57fa\u56e0\uff0c\u5b83\u7d93\u904e\u8b8a\u7570\uff0c\u53ef\u4ee5\u628a\u751f\u7269\u6642\u9418\u8abf\u5feb\u3001\u8abf\u6162\u3001\u751a\u81f3\u95dc\u6389\u3002\u96d6\u7136\u9019\u500b\u767c\u73fe\u672c\u8eab\u4e26\u6c92\u6709\u8aaa\u660e\u751f\u7269\u6642\u9418\u5982\u4f55\u904b\u4f5c\uff0c\u4f46\u5b83\u8e0f\u51fa\u4e86\u7b2c\u4e00\u6b65\uff0c\u70ba\u784f\u7a76\u63a7\u5236\u665d\u591c\u7bc0\u5f8b\u7684\u6a5f\u5236\u6253\u958b\u4e86\u5927\u9580\u3002\u4eca\u5c46\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b78\u8207\u91ab\u5b78\u734e\u7684\u5f97\u734e\u8005\u5091\u5f17\u7406\uff0e\u970d\u723e\u3001\u9081\u514b\u723e\uff0e\u7f85\u65af\u5df4\u6b8a\u548c\u9081\u514b\u723e\uff0e\u694a\uff0c\u6cbf\u8457\u9019\u500b\u65b9\u5411\u5c55\u958b\u784f\u7a76\uff0c\u5229\u7528\u57fa\u56e0\u8b8a\u7570\u679c\u8805\uff0c\u9032\u884c\u4e86\u4e00\u7cfb\u5217\u958b\u5275\u6027\u7684\u5be6\u9a57\uff0c\u63ed\u793a\u4e86\u64cd\u63a7\u665d\u591c\u7bc0\u5f8b\u7684\u5206\u5b50\u6a5f\u5236\u3002\u9019\u500b\u6a5f\u5236\u4e0d\u50c5\u53ea\u5b58\u5728\u65bc\u679c\u8805\uff0c\u4e5f\u5b58\u5728\u65bc\u4eba\u985e\u3002<\/p>
\u76f8\u95dc\u7684\u7814\u7a76\u5de5\u4f5c\u57281984\u5e74\u53d6\u5f97\u7b2c\u4e00\u500b\u7a81\u7834\u3002\u7576\u6642\uff0c\u5728\u5e03\u862d\u6234\u65af\u5927\u5b78\u7684\u970d\u723e\u8207\u7f85\u65af\u5df4\u6b8a\u7684\u7d44\u5408\uff0c\u548c\u6d1b\u514b\u83f2\u52d2\u5927\u5b78\u7684\u694a\uff0c\u5206\u5225\u8907\u88fd (\u6216\u7a31\u514b\u9686 clone) \u4e86\u679c\u8805 (Drosophila melanogaster) \u7684\u9031\u671f\u57fa\u56e0 (period gene)\uff0c\u9019\u500b\u57fa\u56e0\u82e5\u7d93\u904e\u8b8a\u7570\uff0c\u5c31\u53ef\u4ee5\u6539\u8b8a\u679c\u8805\u7684\u665d\u591c\u7bc0\u5f8b\u3002\u9019\u500b\u767c\u73fe\u5e36\u4f86\u4e86\u970d\u723e\u8207\u7f85\u65af\u5df4\u6b8a\u7d44\u5408\u7684\u7b2c\u4e8c\u500b\u7a81\u7834\u3002\u4ed6\u5011\u784f\u7a76\u679c\u8805\u8166\u5167\u7531\u9031\u671f\u57fa\u56e0\u6240\u7de8\u78bc\u7684\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178 (mRNA) \u548c\u86cb\u767d\uff0c\u767c\u73fe\u5b83\u5011\u7684\u6c34\u5e73\u5448\u73fe\u665d\u591c\u7bc0\u5f8b\u6027\u7684\u8b8a\u52d5\u3002\u800c\u4e14\u9031\u671f\u57fa\u56e0\u82e5\u7522\u751f\u8b8a\u7570\uff0c\u53ef\u4ee5\u6539\u8b8a\u9019\u4e9b\u7bc0\u5f8b\u7684\u6ce2\u52d5\u3002\u9019\u4e9b\u767c\u73fe\u70ba\u63a7\u5236\u751f\u7269\u6642\u9418\u7684\u57fa\u672c\u6a5f\u5236\u63d0\u4f9b\u4e86\u7b2c\u4e00\u500b\u7dda\u7d22\ufe55\u9031\u671f\u57fa\u56e0\u7684\u86cb\u767d\u7522\u7269\u53ef\u4ee5\u6309\u845724\u5c0f\u6642\u7684\u9031\u671f\u5faa\u74b0\uff0c\u6291\u5236\u81ea\u8eab\u751f\u7522\u7684\u53cd\u994b\u8def\u7dda\u3002\u694a\u8207\u970d\u723e\/\u7f85\u65af\u5df4\u6b8a\u7d44\u5408\u96a8\u5f8c\u5c55\u958b\u7814\u7a76\uff0c\u63ed\u793a\u66f4\u591a\u548c\u751f\u7269\u6642\u9418\u6a5f\u5236\u6709\u95dc\u7684\u57fa\u56e0\uff0c\u4e26\u63d0\u4f9b\u4e86\u8a73\u76e1\u7684\u4fe1\u606f\uff0c\u8aaa\u660e\u5b83\u5011\u7684\u7522\u7269\u5982\u4f55\u904b\u4f5c\uff0c\u600e\u6a23\u901a\u904e\u9031\u671f\u57fa\u56e0\u7684mRNA\u53ca\u86cb\u767d\u7684\u6c34\u5e73\uff0c\u63a7\u5236\u665d\u591c\u7bc0\u5f8b\uff0c\u53ca\u65e5\u5149\u5982\u4f55\u91cd\u65b0\u8abf\u6574\u751f\u7269\u6642\u9418\u3002 <\/p>
\u73fe\u5728\u5df2\u77e5\u970d\u723e\u3001\u7f85\u65af\u5df4\u6b8a\u548c\u694a\u5728\u679c\u8805\u4e2d\u6240\u767c\u73fe\u7684\u665d\u591c\u7bc0\u5f8b\u7684\u57fa\u672c\u6a5f\u5236\uff0c\u4e5f\u9069\u7528\u65bc\u5176\u4ed6\u751f\u7269\uff0c\u5305\u62ec\u4eba\u985e\u5728\u5167\u3002\u9019\u4e9b\u6a5f\u5236\u548c\u4eba\u985e\u75be\u75c5\u4e4b\u9593\u7684\u95dc\u4fc2\u5df2\u5145\u5206\u986f\u793a\u51fa\u4f86\u3002\u4f8b\u5982\uff0c\u4eba\u985e\u6709\u5169\u500b\u57fa\u56e0\uff0c\u8207\u679c\u8805\u7684\u665d\u591c\u7bc0\u5f8b\u57fa\u56e0\u5c0d\u61c9\uff0c\u800c\u9019\u5169\u500b\u57fa\u56e0\u8207\u5f71\u97ff\u7761\u7720\u7bc0\u594f\u7684\u907a\u50b3\u75c5\u5448\u73fe\u76f8\u95dc\u3002 <\/p>
\u6709\u95dc\u300c\u90b5\u9038\u592b\u734e\u300d<\/u><\/p>
\u300c\u90b5\u9038\u592b\u734e\u300d\u70ba\u570b\u969b\u6027\u734e\u9805\uff0c\u5f97\u734e\u4eba\u7686\u6d3b\u8e8d\u65bc\u5176\u5b78\u8853\u9818\u57df\uff0c\u5728\u5b78\u8853\u7814\u7a76\u3001\u79d1\u5b78\u7814\u7a76\u53ca\u61c9\u7528\u4e0a\u6709\u7a81\u7834\u6027\u7684\u6210\u679c\uff0c\u6216\u5c0d\u6587\u5316\u85dd\u8853\u6709\u5091\u51fa\u8ca2\u737b\uff0c\u6216\u5728\u5176\u4ed6\u9818\u57df\u6709\u5353\u8d8a\u4e4b\u6210\u5c31\u3002\u8a55\u9078\u7684\u539f\u5247\u4e3b\u8981\u8003\u616e\u5019\u9078\u4eba\u4e4b\u5c08\u696d\u5c0d\u63a8\u52d5\u793e\u6703\u9032\u6b65\u3001\u63d0\u9ad8\u4eba\u985e\u751f\u6d3b\u8cea\u7d20\uff0c\u4ee5\u53ca\u8c50\u5bcc\u4eba\u985e\u7cbe\u795e\u6587\u660e\u7684\u8ca2\u737b\u3002\u5019\u9078\u4eba\u8fd1\u671f\u7684\u6210\u679c\u5c07\u7372\u512a\u5148\u8003\u616e\u3002 <\/p>
\u300c\u90b5\u9038\u592b\u734e\u300d\u4e43\u6309\u90b5\u9038\u592b\u7235\u58eb\u610f\u9858\uff0c\u65bc2002\u5e7411\u6708\u6210\u7acb\uff0c2004\u5e74\u9812\u767c\u9996\u5c46\u734e\u9805\uff0c\u73fe\u70ba\u7b2c\u5341\u5c46\u3002\u300c\u90b5\u9038\u592b\u734e\u300d\u8a2d\u6709\u4e09\u500b\u734e\u9805\uff0c\u5206\u5225\u70ba\u5929\u6587\u5b78\u734e\u3001\u751f\u547d\u79d1\u5b78\u8207\u91ab\u5b78\u734e\uff0c\u4ee5\u53ca\u6578\u5b78\u79d1\u5b78\u734e\u3002<\/p>","show_as_achievement":false,"achievement_category":[],"show_as_clarification":false,"show_as_announcement":false,"photos":null,"attachments":null,"video_source":null,"video_file":null,"add_play_button":false,"video_caption":"","show_migration":false,"original_id":"1632","photos_original":[{"photo":"52425be692528.jpg","caption":"(\u5de6\u8d77)\u4e2d\u5927\u751f\u7269\u91ab\u5b78\u5b78\u9662\u9673\u6587\u6a02\u6559\u6388\u3001\u9038\u592b\u66f8\u9662\u69ae\u8b7d\u9662\u52d9\u59d4\u54e1\u9673\u4f73\u9f10\u6559\u6388\u3001\u4e2d\u5927\u526f\u6821\u9577\u970d\u6cf0\u8f1d\u6559\u6388\u30012013\u5e74\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b78\u8207\u91ab\u5b78\u734e\u5f97\u4e3b\u5091\u5f17\u7406\u2022\u970d\u723e\u6559\u6388(Prof. Jeffrey C. Hall)\u3001\u9081\u514b\u723e\u2022\u7f85\u65af\u5df4\u6b8a\u6559\u6388(Prof. Michael Rosbash)\u53ca\u9081\u514b\u723e\u2022\u694a\u6559\u6388(Prof. Michael W. Young)\u3001\u9038\u592b\u66f8\u9662\u9662\u9577\u9673\u5fd7\u8f1d\u6559\u6388\u3002"},{"photo":"52425be866d81.jpg","caption":"\u5091\u5f17\u7406\u2022\u970d\u723e\u6559\u6388\u4ee5\u300c\u4eba\u7686\u5c0b\u5922\u300d\u70ba\u984c\u767c\u8868\u6f14\u8aaa\u3002"},{"photo":"52425bea7d28d.jpg","caption":"\u9081\u514b\u723e\u2022\u7f85\u65af\u5df4\u6b8a\u6559\u6388\u4ee5\u300c\u665d\u591c\u7bc0\u5f8b\u7684\u5faa\u74b0\u63a7\u5236\uff1a\u56de\u671b\u5eff\u8f09\u8207\u5c55\u671b\u672a\u4f86\u300d\u70ba\u984c\u767c\u8868\u6f14\u8aaa\u3002"},{"photo":"52425bec503ff.jpg","caption":"\u9081\u514b\u723e\u2022\u694a\u6559\u6388\u4ee5\u300c\u63a7\u5236\u7761\u7720\u53ca\u665d\u591c\u7bc0\u5f8b\u7684\u57fa\u56e0\u300d\u70ba\u984c\u767c\u8868\u6f14\u8aaa\u3002"},{"photo":"52425bee46afd.jpg","caption":"(\u5de6\u8d77)\u4e2d\u5927\u751f\u7269\u91ab\u5b78\u5b78\u9662\u9673\u6587\u6a02\u6559\u6388\u30012013\u5e74\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b78\u8207\u91ab\u5b78\u734e\u5f97\u4e3b\u5091\u5f17\u7406\u2022\u970d\u723e\u6559\u6388\u3001\u9081\u514b\u723e\u2022\u7f85\u65af\u5df4\u6b8a\u6559\u6388\u53ca\u9081\u514b\u723e\u2022\u694a\u6559\u6388\u3002"}],"attachments_original":null},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/wp-json\/wp\/v2\/press\/48627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/wp-json\/wp\/v2\/press"}],"about":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/wp-json\/wp\/v2\/types\/press"}],"version-history":[{"count":0,"href":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/wp-json\/wp\/v2\/press\/48627\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/wp-json\/wp\/v2\/media?parent=48627"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cpr.cuhk.edu.hk\/tc\/wp-json\/wp\/v2\/tags?post=48627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}