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1992\uff09\u3001\u767c\u73fe\u5f9e\u9644\u776a\u982d\u90e8\u5206\u6ccc\u7684\u4e00\u500b\u65b0\u9632\u79a6\u7d20\u53ca\u5176\u5c0d\u7cbe\u5b50\u6210\u719f\u7684\u5f71\u97ff\uff08\u300a\u79d1\u5b78\u96dc\u8a8c\u300b<em>Science<\/em>, 2001\u53ca\u300a\u81ea\u7136\u2014\u7d30\u80de\u751f\u7269\u5b78\u300b<em>Nature Cell Biology<\/em>, 2004\uff09\u53ca\u56ca\u6027\u7e96\u7dad\u5316\u8de8\u819c\u96fb\u5c0e\u8abf\u7bc0\u5668\uff08CFTR\uff09\u5728\u751f\u6b96\u53ca\u4e0d\u80b2\u4e2d\u7684\u89d2\u8272\uff08\u300a\u81ea\u7136\u2014\u7d30\u80de\u751f\u7269\u5b78\u300b<em>Nature Cell Biology<\/em>, 2003\uff09\u3002\u5176\u958b\u5275\u6027\u767c\u73fe\u4ee4\u4eba\u985e\u52a0\u6df1\u4e86\u89e3\u4e0a\u76ae\u7d44\u7e54\u5206\u6ccc\u5c0d\u4eba\u9ad4\u6a5f\u80fd\uff0c\u5c24\u5176\u662f\u5c0d\u751f\u6b96\u6a5f\u80fd\u7684\u5f71\u97ff\uff0c\u4ea6\u5c0d\u6cbb\u7642\u4e0d\u80b2\u53ca\u907f\u5b55\u65b9\u6cd5\u5e36\u4f86\u91cd\u8981\u555f\u793a\u3002<\/p>\r\n<p>\u9673\u6559\u6388\u5728\u751f\u7269\u91ab\u5b78\u65b9\u9762\u7684\u8ca2\u737b\uff0c\u70ba\u5979\u5e36\u4f86\u591a\u500b\u91cd\u8981\u734e\u8b7d\uff0c\u5305\u62ec\u4e00\u4e5d\u4e5d\u4e03\u5e74\u7372\u570b\u5bb6\u81ea\u7136\u79d1\u5b78\u734e\uff0c\u53ca\u4e8c\u96f6\u96f6\u96f6\u5e74\u7372\u570b\u5bb6\u81ea\u7136\u79d1\u5b78\u57fa\u91d1\u6703\u5091\u51fa\u9752\u5e74\u7814\u7a76\u734e\u3002<\/p>\r\n<p>\u9673\u6559\u6388\u65bc\u4e00\u4e5d\u516b\u4e09\u5e74\u5f9e\u7f8e\u570b\u4f0a\u5229\u8afe\u5927\u5b78\u9999\u6ab3\u5206\u6821\u7372\u5f97\u751f\u7269\u5de5\u7a0b\u5b78\u7406\u5b78\u58eb\uff0c\u5176\u5f8c\u65bc\u4e00\u4e5d\u516b\u516b\u5e74\u53d6\u5f97\u751f\u7269\u7269\u7406\u5b78\u54f2\u5b78\u535a\u58eb\u5b78\u4f4d\u3002\u7562\u696d\u5f8c\uff0c\u9673\u6559\u6388\u65bc\u829d\u52a0\u54e5\u5927\u5b78\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u4e26\u65bc\u4e00\u4e5d\u4e5d\u4e09\u5e74\u52a0\u5165\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u4efb\u52a9\u7406\u6559\u6388\u3002\u4e8c\u96f6\u96f6\u516d\u5e74\uff0c\u9673\u6559\u6388\u6649\u5347\u70ba\u751f\u7406\u5b78\u8b1b\u5ea7\u6559\u6388\u3002\u9673\u5c0f\u7ae0\u6559\u6388\u51fa\u4efb\u591a\u500b\u570b\u969b\u5b78\u8853\u671f\u520b\u7de8\u8f2f\u59d4\u54e1\u6703\u59d4\u54e1\uff0c\u4e26\u70ba\u5167\u5730\u8d85\u904e\u5341\u56db\u6240\u5927\u5b78\u53ca\u7814\u7a76\u6a5f\u69cb\u64d4\u4efb\u5ba2\u5ea7\u6559\u6388\u3002\u53e6\u5916\uff0c\u9673\u6559\u6388\u4e5f\u70ba\u591a\u500b\u570b\u969b\u57fa\u91d1\u6703\uff0c\u5305\u62ec\u4e16\u754c\u885b\u751f\u7d44\u7e54\u3001\u7f8e\u570b\u570b\u5bb6\u79d1\u5b78\u57fa\u91d1\u6703\u3001\u4e2d\u570b\u570b\u5bb6\u81ea\u7136\u79d1\u5b78\u57fa\u91d1\u6703\u53ca\u82f1\u570b\u3001\u5fb7\u570b\u3001\u610f\u5927\u5229\u7b49\u570b\u7684\u5404\u7a2e\u57fa\u91d1\u6703\uff0c\u8a55\u5be9\u7814\u7a76\u8ab2\u984c\u3002<\/p>\r\n<p>\u9673\u5bb6\u4eae\u6559\u6388\u70ba\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u91ab\u5b78\u9662\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u8b1b\u5ea7\u6559\u6388\u53ca\u5a01\u723e\u65af\u89aa\u738b\u91ab\u9662\u540d\u8b7d\u9867\u554f\u91ab\u751f\u3002<\/p>\r\n<p>\u9673\u6559\u6388\u4e00\u4e5d\u516b\u516b\u5e74\u7562\u696d\u65bc\u4e2d\u6587\u5927\u5b78\u91ab\u5b78\u9662\uff0c\u4e00\u4e5d\u4e5d\u516b\u5e74\u7372\u4e2d\u5927\u91ab\u5b78\u535a\u58eb\u5b78\u4f4d\u3002\u4e00\u4e5d\u4e5d\u4e09\u5e74\uff0c\u9673\u6559\u6388\u7372\u88d8\u69ce\u57fa\u91d1\u6703\u79d1\u7814\u734e\u8d74\u52a0\u62ff\u5927\u5361\u52a0\u5229\u5927\u5b78\u6df1\u9020\u5be6\u9a57\u6027\u809d\u81df\u79fb\u690d\u3002\u4e00\u4e5d\u4e5d\u4e94\u5e74\u56de\u6e2f\u5f8c\uff0c\u65bc\u5a01\u723e\u65af\u89aa\u738b\u91ab\u9662\u64d4\u4efb\u9ad8\u7d1a\u91ab\u751f\u3002\u4e00\u4e5d\u4e5d\u4e03\u5e74\uff0c\u9673\u6559\u6388\u52a0\u5165\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u91ab\u5b78\u9662\u64d4\u4efb\u8b1b\u5e2b\uff0c\u4e26\u7e7c\u7e8c\u517c\u4efb\u5a01\u723e\u65af\u89aa\u738b\u91ab\u9662\u5168\u8077\u8178\u80c3\u5c08\u79d1\u53ca\u5167\u7aba\u93e1\u5c08\u79d1\u91ab\u751f\u3002\u9673\u6559\u6388\u65bc\u4e8c\u96f6\u96f6\u4e94\u5e74\u64e2\u5347\u70ba\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u8b1b\u5ea7\u6559\u6388\u3002\u9673\u6559\u6388\u7684\u6559\u5b78\u8868\u73fe\u5099\u53d7\u80af\u5b9a\uff0c\u7531\u4e00\u4e5d\u4e5d\u4e5d\u81f3\u4e8c\u96f6\u96f6\u56db\u5e74\u9023\u7e8c\u4e94\u5e74\u7372\u9078\u70ba\u5168\u5e74\u6700\u4f73\u6559\u5e2b\u734e\uff0c\u4e8c\u96f6\u96f6\u96f6\u5e74\u7372\u6821\u9577\u6a21\u7bc4\u6559\u5b78\u734e\u53ca\u4e8c\u96f6\u96f6\u56db\u5e74\u7372\u540d\u5e2b\u734e\u3002<\/p>\r\n<p>\u9673\u6559\u6388\u4e0d\u4f46\u6709\u51fa\u8272\u7684\u6559\u5b78\u8868\u73fe\uff0c\u5728\u7814\u7a76\u4e0a\u540c\u6a23\u6210\u5c31\u5353\u8d8a\u3002\u4ed6\u70ba\u570b\u969b\u77e5\u540d\u5b78\u8005\uff0c\u5728\u963f\u65af\u5339\u9748\u7684\u8655\u65b9\u53ca\u6d88\u5316\u6027\u6f70\u760d\u51fa\u8840\u5169\u500b\u7814\u7a76\u9818\u57df\u4e0a\u3002\u9673\u6559\u6388\u70ba\u9996\u4f4d\u7f8e\u570b\u672c\u571f\u4ee5\u5916\u4eba\u58eb\u7372\u7f8e\u570b\u8178\u80c3\u91ab\u5b78\u5b78\u9662\u9812\u6388David Y. 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