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Biology &ndash; Nature<\/em><\/strong><strong>)<em> <\/em><\/strong>\u53d1\u8868\u3002<\/p><p><strong>B<\/strong><strong>\u7ec6<\/strong><strong>\u80de\u6570\u91cf<\/strong><strong>\u4f30<\/strong><strong>\u7b97<\/strong><strong>\u764c<\/strong><strong>\u75c7<\/strong><strong>\u75c5\u4eba\u7684<\/strong><strong>\u5b58\u6d3b\u671f<\/strong><strong><\/strong><\/p><p>B\u7ec6\u80de\u662f\u4e00\u79cd\u767d\u8840\u7403\u7ec6\u80de\uff0c\u4e3a\u8eab\u4f53\u62b5\u5fa1\u5f02\u7269\uff0c\u5982\u7ec6\u83cc\u3001\u75c5\u6bd2\uff0c\u751a\u81f3\u764c\u7ec6\u80de\u7b49\u3002\u6b64\u514d\u75ab\u7ec6\u80de\u53ef\u4ee5\u5236\u9020\u6297\u4f53\u4ee5\u4fa6\u6d4b\u5916\u6765\u7269\u5e76\u542f\u52a8\u514d\u75ab\u53cd\u5e94\uff0c\u653b\u51fb\u53ca\u6d88\u706d\u5165\u4fb5\u8005\u5982\u81f4\u75c5\u539f\u3002<\/p><p>\u4e2d\u5927\u533b\u5b66\u9662\u751f\u7269\u533b\u5b66\u5b66\u9662\u526f\u6559\u6388<strong>\u5415\u4f1f\u6b23\u6559\u6388<\/strong>\u8fdb\u4e00\u6b65\u89e3\u91caB\u7ec6\u80de\u7684\u64cd\u4f5c\uff0c\u5979\u8bf4\uff1a\u300cB\u7ec6\u80de\u5982\u9a7b\u5b88\u5728\u57ce\u95e8\u5916\u7684\u58eb\u5175\uff0c\u9a8c\u8bc1\u5916\u6765\u4eba\u58eb\u7684\u8eab\u4efd\uff0c\u5982\u53d1\u73b0\u4efb\u4f55\u5371\u9669\uff0c\u4fbf\u4f1a\u5411\u5c06\u519b\uff08\u5373\u514d\u75ab\u7cfb\u7edf\uff09\u6c47\u62a5\u3002\u4f53\u5185\u7684\u53e6\u4e00\u79cd\u514d\u75ab\u7ec6\u80deT\u7ec6\u80de\u5c31\u662f\u6b66\u5668\uff0c\u8d1f\u8d23\u653b\u51fb\u53ca\u6d88\u706d\u5165\u4fb5\u8005\u3002\u8fd0\u7528T\u7ec6\u80de\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e8e\u8fd1\u5341\u5e74\u7684\u53d1\u5c55\u6e10\u8d8b\u6210\u719f\uff0c\u76f8\u53cdB\u7ec6\u80de\u7684\u4e34\u5e8a\u529f\u7528\u81f3\u4eca\u4ecd\u672a\u6709\u660e\u786e\u7684\u533b\u5b66\u7ed3\u8bba\u3002\u300d<\/p><p>\u7531\u57fa\u56e0\u7ec4\u5b66\u4e13\u5bb6\u5415\u4f1f\u6b23\u6559\u6388\u5e26\u9886\u7684\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u5c0f\u7ec4\u5229\u7528\u764c\u75c7\u57fa\u56e0\u7ec4\u5b66\u548c\u75c5\u4eba\u5b58\u6d3b\u671f\u5927\u6570\u636e\uff0c\u53d1\u73b0\u80bf\u7624\u4e2dB\u7ec6\u80de\u7684\u6570\u91cf\u4e0e\u4e03\u79cd\u764c\u75c7(\u5305\u62ec\u4f4e\u7ea7\u522b\u795e\u7ecf\u80f6\u8d28\u7624\u3001\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u80f8\u817a\u7624\u3001\u80be\u764c\u3001\u80ba\u764c\u3001\u5934\u9888\u764c\u548c\u5b50\u5bab\u764c\uff09\u7684\u60a3\u8005\u751f\u5b58\u671f\u6709\u5173\uff0c\u6c34\u5e73\u6108\u9ad8\uff0c\u5b58\u6d3b\u671f\u4e00\u822c\u90fd\u8f83\u957f\u3002\u5979\u8868\u793a\uff1a\u300c\u6b64\u4e43\u975e\u5e38\u5d2d\u65b0\u7684\u53d1\u73b0\uff0c\u5c06\u4e3a\u764c\u75c7\u9884\u540e\u63d0\u4f9b\u65b0\u65b9\u5411\u53ca\u542f\u793a\u3002\u300d<\/p><p><strong>\u57fa\u56e0<\/strong><strong>GPR18<\/strong><strong>\u6210<\/strong><strong>\u4e3a<\/strong><strong>\u764c<\/strong><strong>\u75c7<\/strong><strong>\u9884\u540e\u7684\u751f\u7269\u6807\u8bb0<\/strong><\/p><p>\u5415\u6559\u6388\u56e2\u961f\u4ea6\u4e3a29\u79cd\u764c\u75c7\u8fdb\u884c\u5927\u578b\u7684\u7ec4\u5b66\u5206\u6790\uff0c\u5e76\u8bc6\u522b\u51fa\u4e00\u79cd\u5b58\u5728\u4e8eB\u7ec6\u80de\u8868\u9762\u3001\u540d\u4e3aGPR18\u7684\u57fa\u56e0\u3002\u5176\u57fa\u56e0\u6c34\u5e73\u4ea6\u53ef\u4f5c\u53c2\u8003\uff0c\u7528\u4ee5\u9884\u6d4b\u4e5d\u7c7b\u764c\u75c7\u75c5\u4eba\u5b58\u6d3b\u671f\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u3001\u4f4e\u7ea7\u522b\u795e\u7ecf\u80f6\u8d28\u7624\u3001\u8089\u7624\u3001\u80ba\u764c\u3001\u5934\u9888\u764c\u3001\u5b50\u5bab\u9888\u764c\u3001\u809d\u764c\u3001\u4e73\u817a\u764c\u53ca\u80be\u4e0a\u817a\u76ae\u8d28\u80bf\u7624\u3002<\/p><p>\u4ee5\u53d7\u4eba\u7c7b\u4e73\u5934\u7624\u75c5\u6bd2\uff08HPV\uff09\u611f\u67d3\u7684\u5934\u9888\u764c\u75c5\u4eba\u4e3a\u4f8b\uff0c\u56e2\u961f\u53d1\u73b0\u5018\u82e5\u4ed6\u4eec\u4f53\u5185\u6709\u9ad8GPR18\u57fa\u56e0\u6c34\u5e73\uff0c\u5e73\u5747\u90fd\u6709\u8f83\u957f\u7684\u5b58\u6d3b\u671f\u3002<\/p><table border=\"1\" cellspacing=\"0\" cellpadding=\"0\"><tbody><tr><td valign=\"top\" width=\"420\"><p>HPV\u611f\u67d3\u5934\u9888\u764c\u75c5\u4eba<\/p><\/td><td valign=\"top\" width=\"191\"><p>\u6574\u4f53\u5b58\u6d3b\u671f<\/p><\/td><\/tr><tr><td valign=\"top\" width=\"420\"><p>\u4f53\u5185\u6709<strong>\u8f83\u9ad8<\/strong>GPR18\u57fa\u56e0\u6c34\u5e73<\/p><\/td><td valign=\"top\" width=\"191\"><p>68.4 \u4e2a\u6708<\/p><\/td><\/tr><tr><td valign=\"top\" width=\"420\"><p>\u4f53\u5185\u6709<strong>\u8f83\u4f4e<\/strong>GPR18\u57fa\u56e0\u6c34\u5e73<\/p><\/td><td valign=\"top\" width=\"191\"><p>57.4 \u4e2a\u6708<\/p><\/td><\/tr><\/tbody><\/table><p><br 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class=\"1\">\u662f\u6b21\u7814\u7a76\u62a5\u544a\u7531\u5415\u6559\u6388\u53ca\u535a\u58eb\u540e\u7814\u7a76\u5458\u5218\u96e8\u8fb0\u535a\u58eb\u8bbe\u8ba1\u53ca\u64b0\u5199\u3002\u6b64\u7814\u7a76\u7531\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u8054\u5408\u4e66\u9662\u7684\u300c\u5229\u5e0c\u614e\u57fa\u91d1\u7814\u7a76\u6d25\u8d34\u8ba1\u5212\u300d\u53ca\u300c\u4e66\u9662\u57fa\u91d1\u7814\u7a76\u6d25\u8d34\u8ba1\u5212\u300d\u8d44\u52a9 (CA11281; CA11286)\u3002\u7814\u7a76\u8be6\u60c5\u53ef\u6d4f\u89c8: <a 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