\u6709\u7814\u7a76\u6307\u6cbb\u7597\u963f\u5179\u6d77\u9ed8\u75c7\uff08\u4fd7\u79f0\u300c\u8001\u4eba\u8ba4\u77e5\u969c\u788d\u75c7\u300d\uff09\u987b\u5728\u60a3\u8005\u53d1\u75c5\u521d\u671f\u5f00\u59cb\u624d\u6709\u6548\uff0c\u7136\u800c\uff0c\u73b0\u65f6\u672c\u6e2f\u80fd\u591f\u8bca\u65ad\u65e9\u671f\u963f\u5179\u6d77\u9ed8\u75c7\u7684\u68c0\u6d4b\u5e76\u4e0d\u666e\u904d\u3002\u4e3a\u4f7f\u7b5b\u67e5\u65e9\u671f\u963f\u5179\u6d77\u9ed8\u75c7\u7684\u68c0\u6d4b\u66f4\u5feb\u6377\u3001\u7ecf\u6d4e\u548c\u666e\u53ca\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\uff08\u4e2d\u5927\uff09\u533b\u5b66\u9662\u5728\u79cd\u5b50\u57fa\u91d1\u6709\u9650\u516c\u53f8\u53ca\u533b\u7597\u536b\u751f\u7814\u7a76\u57fa\u91d1\uff08\u98df\u7269\u53ca\u536b\u751f\u5c40\uff09\u652f\u6301\u4e0b\uff0c\u4e0e\u517b\u548c\u533b\u9662\u5408\u4f5c\u5c55\u5f00\u300c\u65e9\u671f\u963f\u5179\u6d77\u9ed8\u75c7\u7b5b\u67e5\u7814\u7a76\u300d\uff08SEEDS Study\uff09\uff0c\u4ee5\u63a2\u8ba8\u534e\u4eba\u963f\u5179\u6d77\u9ed8\u75c7\u7684\u751f\u7269\u6807\u8bb0 (biomarkers) \u4f5c\u8ba4\u77e5\u969c\u788d\u75c7\u68c0\u6d4b\u3002 <\/p>
\u6108\u65e9\u68c0\u6d4b \u6108\u65e9\u4ecb\u5165\u8ba4\u77e5\u969c\u788d\u75c7\u6cbb\u7597<\/strong> <\/p> \u65e9\u5e74\u4e2d\u5927\u7814\u7a76\u53d1\u73b0\uff0c\u672c\u6e2f70\u5c81\u4ee5\u4e0a\u957f\u8005\u6bcf10\u4eba\u4fbf\u67091\u4f4d\u8ba4\u77e5\u969c\u788d\u60a3\u8005\uff0c\u800c85\u5c81\u4ee5\u4e0a\u5219\u6bcf3\u4eba\u4fbf\u67091\u4f4d\u60a3\u8005\u3002\u60a3\u8005\u4e2d\u53ea\u6709\u5341\u5206\u4e00\u4eba\u66fe\u7ecf\u6c42\u533b\u6216\u5df2\u786e\u8bca\u3002 <\/p> \u8ba4\u77e5\u969c\u788d\u75c7\u60a3\u8005\u8d85\u8fc7\u4e00\u534a\u6210\u56e0\u662f\u963f\u5179\u6d77\u9ed8\u75c7\uff08Alzheimer’s disease\uff09\uff0c\u4ed6\u4eec\u7684\u8111\u90e8\u4f1a\u79ef\u805a\u4e0d\u6b63\u5e38\u7684\u7269\u8d28–\u6dc0\u7c89\u72b6\u86cb\u767d\u53ca\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u5bfc\u81f4\u8111\u7ec6\u80de\u9010\u6e10\u6b7b\u4ea1\uff0c\u4ece\u800c\u5f15\u81f4\u6e10\u8fdb\u5f0f\u7684\u8ba4\u77e5\u9000\u6b65\u3002 <\/p> \u4e2d\u5927\u533b\u5b66\u9662\u5185\u79d1\u53ca\u836f\u7269\u6cbb\u7597\u5b66\u7cfb\u8111\u795e\u7ecf\u79d1\u4e3b\u4efb\u83ab\u4ef2\u68e0\u6559\u6388<\/strong>\u8868\u793a\uff1a\u300c\u6709\u7814\u7a76\u6307\uff0c\u6291\u5236\u6dc0\u7c89\u72b6\u86cb\u767d\u7684\u6cbb\u7597\u6216\u80fd\u9632\u6b62\u8ba4\u77e5\u80fd\u529b\u8fdb\u4e00\u6b65\u4e0b\u964d\uff0c\u5173\u952e\u5728\u4e8e\u60a3\u8005\u987b\u5728\u5f88\u65e9\u671f\uff0c\u4f8b\u5982\u5728\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d (MCI) \u9636\u6bb5\u63a5\u53d7\u6cbb\u7597\u624d\u6709\u6548\u3002\u6108\u65e9\u53d1\u73b0\uff0c\u6211\u4eec\u4fbf\u53ef\u4ee5\u6108\u65e9\u4ecb\u5165\u6cbb\u7597\uff0c\u4ece\u800c\u51cf\u6162\u751a\u81f3\u904f\u6b62\u75c5\u60c5\u7ee7\u7eed\u6076\u5316\uff0c\u51cf\u8f7b\u75c5\u4eba\u53ca\u5bb6\u5c5e\u7684\u75db\u82e6\u3002\u300d <\/p> \u5bfb\u627e\u534e\u4eba\u4e13\u5c5e\u7684\u751f\u7269\u6807\u8bb0 \u5f00\u62d3\u65b0\u68c0\u6d4b\u65b9\u6cd5<\/strong> <\/p> \u73b0\u65f6\uff0c\u8bca\u65ad\u65e9\u671f\u963f\u5179\u6d77\u9ed8\u75c7\u9700\u8981\u4f7f\u7528\u6dc0\u7c89\u72b6\u86cb\u767d\uff0d\u6b63\u7535\u5b50\u8111\u626b\u63cf (amyloid-PET scan) \uff0c\u6216\u901a\u8fc7\u8170\u690e\u7a7f\u523a\u63d0\u53d6\u8111\u810a\u6db2\u8fdb\u884c\u68c0\u6d4b\u3002\u4e0d\u8fc7\u6b64\u7b49\u68c0\u6d4b\u65b9\u6cd5\u4e0d\u666e\u53ca\u5e76\u5177\u5165\u4fb5\u6027\u3002\u6709\u89c1\u53ca\u6b64\uff0c\u4e2d\u5927\u8111\u795e\u7ecf\u79d1\u56e2\u961f\u5e0c\u671b\u900f\u8fc7\u5f00\u5c55\u300c\u65e9\u671f\u963f\u5179\u6d77\u9ed8\u75c7\u7b5b\u67e5\u7814\u7a76\u300d(SEEDS Study) \uff0c\u901a\u8fc7\u89c6\u7f51\u819c\u5f71\u50cf\u6280\u672f\u53ca\u8840\u6db2\u6d4b\u8bd5\uff0c\u5bfb\u627e\u53ca\u786e\u8ba4\u4ee5\u7b5b\u67e5\u534e\u4eba\u72ec\u6709\u7684\u963f\u5179\u6d77\u9ed8\u75c7\u751f\u7269\u6807\u8bb0\uff0c\u4ee5\u5f00\u62d3\u65b0\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002 <\/p> \u4e2d\u5927\u533b\u5b66\u9662\u773c\u79d1\u53ca\u89c6\u89c9\u79d1\u5b66\u5b66\u7cfb\u52a9\u7406\u6559\u6388\u5f20\u8273\u857e\u535a\u58eb<\/strong>\u89e3\u91ca\uff1a\u300c\u89c6\u7f51\u819c\u662f\u4e2d\u67a2\u795e\u7ecf\u7684\u5ef6\u4f38\uff0c\u8ba9\u6211\u4eec\u53ef\u900f\u8fc7\u773c\u775b\u8fd9\u4e2a\u300e\u7a97\u53e3\u300f\u53bb\u89c2\u5bdf\u8111\u5185\u8840\u7ba1\u548c\u795e\u7ecf\u9000\u5316\u7684\u635f\u5bb3\u3002\u6211\u4eec\u5df2\u6210\u529f\u7814\u53d1\u53ca\u5e94\u7528\u4e0d\u5177\u5165\u4fb5\u6027\u7684\u89c6\u7f51\u819c\u5f71\u50cf\u6280\u672f\u6765\u83b7\u53d6\u751f\u7269\u6807\u8bb0\uff0c\u534f\u52a9\u4e86\u89e3\u773c\u548c\u8111\u5185\u7684\u8840\u7ba1\u53ca\u795e\u7ecf\u75c5\u53d8\u3002\u800c\u900f\u8fc7\u662f\u6b21SEEDS\u7814\u7a76\uff0c\u6211\u4eec\u5e0c\u671b\u66f4\u8fdb\u4e00\u6b65\u4e86\u89e3\u65e9\u671f\u8840\u7ba1\u529f\u80fd\u969c\u788d\u53ca\u8111\u795e\u7ecf\u635f\u5bb3\u5bf9\u8ba4\u77e5\u969c\u788d\u75c7\u7684\u75c5\u7406\u5f71\u54cd\uff0c\u4ee5\u52a9\u7b5b\u67e5\u963f\u5179\u6d77\u9ed8\u75c7\u53ca\u65e9\u671f\u8ba4\u77e5\u969c\u788d\u75c7\u60a3\u8005\u3002\u300d <\/p> \u300c\u65e9\u671f\u963f\u5179\u6d77\u9ed8\u75c7\u7b5b\u67e5\u7814\u7a76\u300d\u73b0\u62db\u52df100\u4f4d\u5e74\u9f84\u4ecb\u4e4e50\u5c81\u81f380\u5c81\u4eba\u58eb\u53c2\u4e0e\uff0c\u5f53\u4e2d\u5305\u62ec\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u3001\u4e25\u91cd\u963f\u5179\u6d77\u9ed8\u8ba4\u77e5\u969c\u788d\u75c7\u60a3\u8005\u53ca\u8ba4\u77e5\u529f\u80fd\u6b63\u5e38\u4eba\u58eb\u3002\u53c2\u52a0\u8005\u5c06\u8fdb\u884c\u5404\u9879\u4e34\u5e8a\u68c0\u6d4b\uff0c\u5305\u62ec\u7531\u4e2d\u5927\u533b\u5b66\u9662\u7814\u7a76\u56e2\u961f\u8fdb\u884c\u7684\u8ba4\u77e5\u80fd\u529b\u6d4b\u8bd5\u3001\u8840\u6db2\u6d4b\u8bd5\u3001\u8111\u90e8\u78c1\u529b\u5171\u632f\u626b\u63cf\u548c\u89c6\u7f51\u819c\u5f71\u50cf\u68c0\u67e5\uff0c\u4ee5\u53ca\u4e8e\u517b\u548c\u533b\u9662\u8fdb\u884c\u6dc0\u7c89\u72b6\u86cb\u767d\uff0d\u6b63\u7535\u5b50\u8111\u626b\u63cf\u3002<\/p> \u4f5c\u4e3a\u9996\u4f4d\u53c2\u4e0e\u6b64\u7814\u7a76\u8ba1\u5212\u7684\u75c5\u4eba\u5bb6\u5c5e\uff0c\u9999\u6e2f\u827a\u4eba\u9ec4\u53c8\u5357\u5148\u751f<\/strong>\u8868\u793a\uff1a\u300c\u533b\u5b66\u7814\u7a76\u5728\u5bf9\u6297\u75be\u75c5\u65f6\u53d1\u6325\u6781\u91cd\u8981\u4f5c\u7528\uff0c\u6240\u4ee5\u6211\u8ba9\u7236\u4eb2\u53c2\u4e0e\u7814\u7a76\u3002\u867d\u7136\u4ed6\u73b0\u5728\u662f\u8ba4\u77e5\u969c\u788d\u75c7\u60a3\u8005\uff0c\u4f46\u4ecd\u6709\u673a\u4f1a\u4e3a\u6cbb\u7597\u8fd9\u75c5\u51fa\u4e00\u5206\u529b\u3002\u6211\u4e5f\u5e0c\u671b\u5176\u4ed6\u60a3\u8005\u3001\u5bb6\u5c5e\u4ee5\u53ca\u516c\u4f17\u5bf9\u6b64\u75c7\u6709\u66f4\u591a\u8ba4\u8bc6\uff0c\u5e76\u61c2\u5f97\u9884\u9632\uff0c\u51cf\u4f4e\u65e5\u540e\u60a3\u75c5\u7684\u673a\u4f1a\u3002\u300d <\/p> \u7814\u7a76\u534f\u4f5c\u5355\u4f4d\u79cd\u5b50\u57fa\u91d1\u6709\u9650\u516c\u53f8\u8463\u4e8b\u6bd5\u8302\u68ee\u5148\u751f<\/strong>\u8868\u793a\uff1a\u300c\u79cd\u5b50\u57fa\u91d1\u4e09\u5e74\u524d\u8d44\u52a9\u4e2d\u5927\u8111\u795e\u7ecf\u79d1\u56e2\u961f\u6210\u7acb\u300e\u65e9\u53d1\u6027\u8ba4\u77e5\u969c\u788d\u75c7\u300f\u7814\u7a76\u767b\u8bb0\u518c\uff0c\u6210\u679c\u4ee4\u4eba\u9f13\u821e\u3002\u4eca\u5e74\u5f97\u77e5\u4ed6\u4eec\u8ba1\u5212\u8fdb\u884c\u65e9\u671f\u7684\u963f\u5179\u6d77\u9ed8\u75c7\u7814\u7a76\uff0c\u51b3\u5b9a\u518d\u6b21\u652f\u6301\uff0c\u8ba9\u963f\u5179\u6d77\u9ed8\u75c7\u7684\u8bca\u65ad\u53d8\u5f97\u51c6\u786e\u5e76\u666e\u53ca\uff0c\u8ba9\u60a3\u8005\u53ca\u65e9\u5f97\u5230\u9002\u5207\u7684\u6cbb\u7597\u3002\u300d <\/p> \u5021\u8bae\u300c\u5065\u5230\u8111\u30fb\u6d3b\u5230\u8001\u300d \u547c\u5401\u5927\u4f17\u7ba1\u7406\u8111\u5065\u5eb7<\/strong> <\/p> 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