{"id":49463,"date":"2017-04-06T00:00:00","date_gmt":"2017-04-06T00:00:00","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/press\/cuhk-uncovers-immune-escape-mechanism-of-cancer-opening-up-new-direction-for-cancer-immunotherapy\/"},"modified":"2017-04-06T00:00:00","modified_gmt":"2017-04-06T00:00:00","slug":"cuhk-uncovers-immune-escape-mechanism-of-cancer-opening-up-new-direction-for-cancer-immunotherapy","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/cuhk-uncovers-immune-escape-mechanism-of-cancer-opening-up-new-direction-for-cancer-immunotherapy\/","title":{"rendered":"\u4e2d\u5927\u6210\u529f\u63ed\u793a\u80bf\u7624\u514d\u75ab\u9003\u8131\u673a\u5236 \u5f00\u62d3\u300c\u514d\u75ab\u7597\u6cd5\u300d\u65b0\u65b9\u5411"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-49463","press","type-press","status-publish","hentry"],"acf":{"title_alt":"","sub_title_alt":"","press_date":"20170406","keep":false,"details":"

\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\uff08\u4e2d\u5927\uff09\u533b\u5b66\u9662\u7684\u6700\u65b0\u7814\u7a76\u63ed\u793a\u4e86\u764c\u7ec6\u80de\u5982\u4f55\u9003\u8fc7\u4eba\u4f53\u7b2c\u4e00\u9053\u514d\u75ab\u9632\u7ebf\u7684\u673a\u5236\uff0c\u5e76\u636e\u6b64\u627e\u5230\u6062\u590d\u6297\u764c\u514d\u75ab\u7cfb\u7edf\u7684\u65b0\u65b9\u6cd5\u3002\u7814\u7a76\u56e2\u961f\u53d1\u73b0\u764c\u7ec6\u80de\u80fd\u591f\u900f\u8fc7\u300c\u80bf\u7624\u5fae\u73af\u5883\u300d\u4e2d\u7684\u751f\u7269\u5206\u5b50Smad3\u53bb\u6291\u5236\u5148\u5929\u514d\u75ab\u7cfb\u7edf\uff0c\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u751f\u957f\u3002\u56e2\u961f\u5df2\u5728\u5b9e\u9a8c\u5c0f\u9f20\u8eab\u4e0a\u8fdb\u884c\u6d4b\u8bd5\u53ca\u5206\u6790\uff0c\u76f8\u4fe1\u8fd9\u9879\u65b0\u53d1\u73b0\u80fd\u591f\u4e3a\u300c\u514d\u75ab\u7597\u6cd5\u300d\u5f00\u5c55\u5168\u65b0\u9886\u57df\uff0c\u5e76\u6709\u671b\u53d1\u5c55\u51fa\u65e2\u5b89\u5168\u53c8\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u5df2\u520a\u8f7d\u4e8e\u56fd\u9645\u9876\u5c16\u79d1\u5b66\u671f\u520a\u300a\u81ea\u7136\u901a\u8baf\u300b(Nature Communications)<\/em><\/strong><\/strong>\u3002 <\/p>

\u764c\u75c7\u4e00\u76f4\u662f\u672c\u6e2f\u7684\u5934\u53f7\u6740\u624b\u3002\u764c\u75c7\u6cbb\u7597\u7684\u56f0\u96be\u4e4b\u5904\u5728\u4e8e\u764c\u7ec6\u80de\u4f1a\u4e0d\u65ad\u4f5c\u51fa\u76f8\u5e94\u7684\u7a81\u53d8\uff0c\u6700\u7ec8\u4ea7\u751f\u8010\u836f\u6027\u800c\u4ece\u6297\u764c\u7597\u7a0b\u4e2d\u5f97\u4ee5\u9003\u8131\uff0c\u6240\u4ee5\u6297\u764c\u6cbb\u7597\u5f80\u5f80\u5728\u4e00\u6bb5\u65f6\u95f4\u540e\u4fbf\u5931\u53bb\u6548\u7528\u3002\u8fd1\u5e74\u79d1\u5b66\u5bb6\u5f00\u59cb\u8457\u773c\u4e8e\u7814\u7a76\u764c\u7ec6\u80de\u7684\u5de2\u7a74\u2500\u2500\u300c\u80bf\u7624\u5fae\u73af\u5883\u300d\uff0c\u900f\u8fc7\u7834\u574f\u6709\u5229\u764c\u7ec6\u80de\u751f\u957f\u7684\u73af\u5883\uff0c\u4ece\u800c\u5c06\u5176\u8fde\u6839\u62d4\u8d77\uff0c\u4ee5\u671f\u6700\u7ec8\u51fb\u9000\u764c\u75c5\u3002 <\/p>

\u6d88\u9664\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6709\u5229\u764c\u7ec6\u80de\u751f\u957f\u7684\u56e0\u7d20\u3000\u6210\u4e3a\u6297\u764c\u6cbb\u7597\u65b0\u7b56\u7565<\/strong> <\/p>

\u300c\u80bf\u7624\u5fae\u73af\u5883\u300d\uff08\u6216\u300c\u764c\u75c7\u5fae\u73af\u5883\u300d\uff09\u662f\u6307\u5728\u80bf\u7624\u4e2d\u5b58\u5728\u7684\u975e\u764c\u7ec6\u80de\u53ca\u7269\u8d28\uff0c\u5b83\u4eec\u90fd\u662f\u5f71\u54cd\u80bf\u7624\u751f\u957f\u7684\u56e0\u7d20\uff0c\u5305\u62ec\u514d\u75ab\u7ec6\u80de\u3001\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u3001\u8840\u7ba1\u751f\u6210\u7ec6\u80de\uff0c\u8fd8\u6709\u7531\u7ec6\u80de\u4ea7\u751f\u51fa\u6765\u652f\u6301\u80bf\u7624\u751f\u957f\u7684\u86cb\u767d\u3002 <\/p>

\u8f6c\u5316\u751f\u957f\u56e0\u5b50-β1\uff08TGF-β1\uff09\u662f\u4f53\u5185\u4e00\u79cd\u591a\u529f\u80fd\u86cb\u767d\uff0c\u4e00\u76f4\u88ab\u89c6\u4e3a\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u7684\u91cd\u8981\u56e0\u7d20\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u80bf\u7624\u4f1a\u901a\u8fc7\u5206\u6cccTGF-β1\u53bb\u6291\u5236\u80bf\u7624\u4e2d\u7684\u5148\u5929\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u4ece\u800c\u5f62\u6210\u9002\u5408\u764c\u7ec6\u80de\u751f\u957f\u7684\u73af\u5883\u3002\u5f53TGF-β1\u4fe1\u53f7\u901a\u8def\u4e2d\u7684\u751f\u7269\u5206\u5b50Smad3\u86cb\u767d\u88ab\u6fc0\u6d3b\u65f6\uff0c\u4fbf\u4f1a\u5927\u5e45\u6291\u5236\u300c\u81ea\u7136\u6740\u624b\u7ec6\u80de \uff08Natural Killer Cell, NK \u7ec6\u80de\uff09\u300d\u7684\u4ea7\u751f\u548c\u529f\u80fd\u3002\u800cNK\u7ec6\u80de\u6b63\u662f\u4eba\u4f53\u91cd\u8981\u7684\u7b2c\u4e00\u9053\u514d\u75ab\u9632\u7ebf\u3002 <\/p>

\u4e2d\u5927\u7814\u7a76\u56e2\u961f\u8fd0\u7528\u4e24\u7ec4\u540c\u57fa\u56e0\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\uff08\u5206\u522b\u4e3a\u5165\u4fb5\u6027\u80ba\u764c\u548c\u9ed1\u8272\u7d20\u7624\uff09\uff0c\u6df1\u5165\u7814\u7a76Smad3\u7684\u4f5c\u7528\u673a\u5236\u3002\u4e0e\u5bf9\u7167\u7ec4\u5c0f\u9f20\u6bd4\u8f83\u4e0b\uff0c\u7ed3\u679c\u663e\u793a\u7f3a\u4e4fSmad3\u7684\u5fae\u73af\u5883\u80fd\u660e\u663e\u51cf\u6162\u80bf\u7624\u7684\u751f\u957f\u901f\u5ea6\u3001\u5165\u4fb5\u6027\u3001\u8f6c\u79fb\u80fd\u529b\u53ca\u5176\u6240\u5f15\u81f4\u7684\u6b7b\u4ea1\u7387\u3002 <\/p>

\u4e2d\u5927\u5353\u654f\u751f\u7269\u533b\u5b66\u8bb2\u5ea7\u6559\u6388\u3001\u533b\u5b66\u9662\u52a9\u7406\u9662\u957f(\u7814\u7a76)\u84dd\u8f89\u8000\u6559\u6388<\/strong>\u8868\u793a\uff1a\u300c\u6211\u4eec\u53d1\u73b0\u5728\u7f3a\u4e4fSmad3\u7684\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0cNK\u7ec6\u80de\u6570\u76ee\u589e\u52a0\u4e8610\u500d\u4e4b\u591a\uff0c\u800c\u5176\u6297\u764c\u80fd\u529b\u4ea6\u5927\u5e45\u63d0\u5347\u3002\u8fd9\u8868\u660eSmad3\u662fTGF-β1\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8fd0\u4f5c\u65f6\u4e00\u4e2a\u91cd\u8981\u7684\u5173\u952e\u3002\u300d <\/strong><\/p>

\u6291\u5236<\/strong>Smad3<\/strong>\u4f5c\u4e3a\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u65b9\u5411<\/strong> <\/p>

\u7814\u7a76\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0cSmad3\u662f\u900f\u8fc7\u76f4\u63a5\u5728\u57fa\u56e0\u5c42\u9762\u6291\u5236\u8f6c\u5f55\u56e0\u5b50E4BP4\u7684\u751f\u6210\uff0c\u4ece\u800c\u963b\u6b62NK\u7ec6\u80de\u7684\u53d1\u80b2\u3002\u56e0\u6b64\uff0c\u5f53Smad3\u88ab\u6d88\u9664\u540e\uff0cNK\u7ec6\u80de\u7684\u751f\u4ea7\u4fbf\u56de\u590d\u6b63\u5e38\uff0c\u7ee7\u800c\u6291\u5236\u764c\u75c7\u3002 <\/p>

\u4e2d\u5927\u533b\u5b66\u9662\u75c5\u7406\u89e3\u5256\u53ca\u7ec6\u80de\u5b66\u7cfb\u7814\u7a76\u5458\u9093\u94ed\u6743\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u300c\u51ed\u8457\u8fd9\u4e9b\u65b0\u7684\u53d1\u73b0\uff0c\u6211\u4eec\u4f5c\u4e86\u4e00\u4e2a\u5047\u8bbe\uff1a\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684Smad3\u53ef\u4ee5\u91cd\u65b0\u5524\u9192\u764c\u75c7\u75c5\u4eba\u7684NK\u7ec6\u80de\u514d\u75ab\u80fd\u529b\u3002\u300d <\/p>

\u56e2\u961f\u5f00\u59cb\u8fdb\u884cSmad3\u6807\u9776\u6297\u764c\u6cbb\u7597\u7684\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u4e8e\u4e24\u79cd\u5b9e\u9a8c\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e0a\u4f7f\u7528Smad3\u6291\u5236\u5242\u3002\u7ed3\u679c\u663e\u793aSmad3\u6807\u9776\u6cbb\u7597\u4e0d\u4f46\u589e\u52a0\u4e86\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684NK\u7ec6\u80de\u6570\u76ee\uff0c\u800c\u4e14\u4ea6\u540c\u65f6\u51cf\u4f4e\u4e86\u5176\u4ed6\u6709\u5229\u764c\u7ec6\u80de\u751f\u957f\u7684\u56e0\u7d20\uff0c\u56e0\u800c\u5927\u5e45\u6291\u5236\u764c\u75c7\u8fdb\u5c55\u3002 <\/p>

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