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href=\"file:\/\/\/C:\/Users\/Dom_cpr\/AppData\/Local\/Microsoft\/Windows\/Temporary%20Internet%20Files\/Content.Outlook\/Z1YOXGTW\/170314_AoE_pr_c_final%20(2).doc#_ftn1\">[1]<\/a>\u7684\u91cd\u70b9\u7814\u7a76\u9879\u76ee\u4e4b\u4e00\uff0c\u6211\u4eec\u6df1\u611f\u81ea\u8c6a\u3002\u300e\u690d\u7269\u4e0e\u73af\u5883\u4e92\u4f5c\u57fa\u56e0\u7ec4\u7814\u7a76\u4e2d\u5fc3\u300f\u7684\u6210\u7acb\uff0c\u5c06\u8fdb\u4e00\u6b65\u4ee4\u9999\u6e2f\u7684\u690d\u7269\u4e0e\u519c\u4e1a\u6280\u672f\uff0c\u63a8\u5e7f\u81f3\u5168\u4e16\u754c\u3002\u300d&nbsp;<\/p><p><strong>\u52a0\u5f3a\u56fd\u9645\u5408\u4f5c\u3000\u5efa\u7acb\u7f51\u7edc\u793e\u7fa4<\/strong>&nbsp;<\/p><p>\u6797\u6559\u6388\u5e0c\u671b\u85c9\u8457\u300c\u690d\u7269\u4e0e\u73af\u5883\u4e92\u4f5c\u57fa\u56e0\u7ec4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u7ee7\u7eed\u6df1\u5316\u4e0e\u56fd\u5185\u53ca\u56fd\u9645\u7814\u7a76\u5355\u4f4d\u7684\u5408\u4f5c\uff0c\u4ee5\u5927\u8c46\u7814\u7a76\u4f5c\u4e3a\u5148\u5bfc\u4f8b\u5b50\uff0c\u628a\u7ecf\u9a8c\u5e94\u7528\u5230\u5176\u4ed6\u4f5c\u7269\u4e4b\u4e2d\u3002\u6797\u6559\u6388\u4e0e\u53d1\u5c55\u4e2d\u56fd\u5bb6\u5df2\u5c55\u5f00\u5408\u4f5c\uff0c<strong>\u4f8b\u5982\u534f\u52a9\u5357\u975e\u5728\u8fb9\u7f18\u571f\u5730\u79cd\u690d\u5927\u8c46\u3001\u534f\u52a9\u963f\u6839\u5ef7\u8fdb\u884c\u6539\u5584\u5927\u8c46\u8d28\u91cf\u7684\u7814\u7a76\u7b49<\/strong>\u3002\u6797\u6559\u6388\u4ea6\u8ba1\u5212\u5efa\u7acb\u4e00\u4e2a\u7f51\u7edc\u5e73\u53f0\u548c\u8d44\u6599\u5e93\uff0c\u4e0e\u4e16\u754c\u5404\u5730\u7684\u7814\u7a76\u4eba\u5458\u5171\u4eab\u8d44\u8baf\u53ca\u6280\u672f\uff0c\u5e76\u4fc3\u8fdb\u5404\u56fd\u4e4b\u95f4\u7684\u6c9f\u901a\u3002&nbsp;<\/p><p><strong>\u6797\u6c49\u660e\u6559\u6388\u7b80\u5386<\/strong>&nbsp;<\/p><p>\u4e2d\u5927\u751f\u547d\u79d1\u5b66\u5b66\u9662\u6559\u6388\u6797\u6c49\u660e\u6559\u6388\u662f\u5927\u8c46\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u517c\u519c\u4e1a\u751f\u7269\u6280\u672f\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\ufe59\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u4f19\u4f34\u5b9e\u9a8c\u5ba4\ufe5a\u526f\u4e3b\u4efb\uff0c\u662f\u5927\u8c46\u9057\u4f20\u57fa\u56e0\u7814\u7a76\u7684\u5148\u9a71\uff0c\u81f4\u529b\u900f\u8fc7\u5176\u7814\u7a76\u7f13\u89e3\u4e16\u754c\u7cae\u98df\u4f9b\u5e94\u548c\u5b89\u5168\u7684\u95ee\u9898\u3002\u6797\u6559\u6388\u5728\u519c\u4e1a\u751f\u7269\u6280\u672f\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e0e\u534e\u5927\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\uff08\u6df1\u5733\uff09\u5408\u4f5c\u4e0b\uff0c\u7834\u89e3\u4e86\u4e09\u5341\u4e00\u79cd\u91ce\u751f\u548c\u57f9\u690d\u5927\u8c46\u7684\u57fa\u56e0\u7ec4\u5bc6\u7801\uff0c\u5f97\u51fa\u91ce\u751f\u5927\u8c46\u6bd4\u57f9\u690d\u5927\u8c46\u6709\u66f4\u9ad8\u751f\u7269\u591a\u6837\u6027\u7684\u7ed3\u8bba\u3002\u8fd9\u7814\u7a76\u6210\u679c\u6210\u4e3a2010\u5e7412\u6708<em>Nature Genetics<\/em>\u7684\u5c01\u9762\u6545\u4e8b\uff0c\u4e3a\u76f8\u5173\u7814\u7a76\u9879\u76ee\u4e0e\u8ba1\u5212\u5960\u5b9a\u57fa\u7840\uff0c\u5927\u8c46\u57fa\u56e0\u7ec4\u7814\u7a76\u81ea\u6b64\u5728\u5168\u7403\u904d\u5730\u5f00\u82b1\u3002&nbsp;<\/p><p>\u5341\u591a\u5e74\u6765\uff0c\u6797\u6559\u6388\u7684\u56e2\u961f\u4e00\u76f4\u91c7\u7528\u9ad8\u7aef\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u79d1\u6280\uff0c\u914d\u4ee5\u5148\u8fdb\u7684\u5206\u5b50\u751f\u7269\u5b66\u6280\u672f\uff0c\u627e\u5bfb\u91ce\u751f\u5927\u8c46\u7684\u8010\u9006\u57fa\u56e0\u30022014\u5e74\uff0c\u4ed6\u6210\u529f\u4ece\u91ce\u751f\u5927\u8c46\u8bc6\u522b\u548c\u590d\u5236\u51fa\u5d2d\u65b0\u7684\u8010\u76d0\u57fa\u56e0\uff0c\u5927\u5927\u63d0\u5347\u53d1\u5c55\u8010\u76d0\u5927\u8c46\u7684\u53ef\u80fd\u6027\uff0c\u7814\u7a76\u6210\u679c\u540c\u5e74\u520a\u4e8e<em>Nature Communications<\/em>\u3002\u6797\u6559\u6388\u540c\u65f6\u4e0e\u5185\u5730\u7684\u5927\u8c46\u80b2\u79cd\u4e13\u5bb6\u5408\u4f5c\uff0c\u57f9\u690d\u53ef\u5728\u76d0\u6e0d\u5316\u571f\u5730\u79cd\u690d\u7684\u5927\u8c46\u3002\u56e2\u961f\u4ea6\u5728\u4e2d\u56fd\u897f\u5317\u90e8\u7684\u534a\u5e72\u65f1\u548c\u5168\u65f1\u5730\u533a\u505a\u5b9e\u9a8c\uff0c\u5180\u671b\u5728\u5927\u8c46\u79cd\u8d28\u8d44\u6e90\u4e2d\u627e\u51fa\u8010\u65f1\u57fa\u56e0\uff0c\u57f9\u690d\u51fa\u8010\u65f1\u5927\u8c46\u3002&nbsp;<\/p><p>\u6797\u6c49\u660e\u6559\u6388\u4e8e\u4e2d\u5927\u53d6\u5f97\u751f\u7269\u5b66\u5b66\u58eb\u53ca\u7855\u58eb\u5b66\u4f4d\uff0c\u4e8e\u7f8e\u56fd\u897f\u5317\u5927\u5b66\u83b7\u5f97\u5206\u5b50\u751f\u7269\u5b66\u535a\u58eb\u5b66\u4f4d\uff0c\u540e\u4efb\u7ebd\u7ea6\u5927\u5b66\u535a\u58eb\u540e\u7814\u7a76\u5458\uff0c\u5e76\u4e8e1997\u5e74\u56de\u5230\u6bcd\u6821\u4e2d\u5927\u4efb\u6559\u3002&nbsp;<\/p><p><strong>\u5353\u8d8a\u5b66\u79d1\u9886\u57df\u8ba1\u5212\u7b80\u4ecb<\/strong><\/p><p>\u5927\u5b66\u6559\u80b2\u8d44\u52a9\u59d4\u5458\u4f1a\uff08\u6559\u8d44\u4f1a\uff09\u4e8e1998\u5e74\u63a8\u51fa\u5353\u8d8a\u5b66\u79d1\u9886\u57df\u8ba1\u5212\uff0c\u81f3\u4eca\u5df2\u63a8\u884c\u4e86\u4e03\u8f6e\u8ba1\u5212\uff0c\u7504\u9009\u4e86\u5171\u5eff\u4e00\u4e2a\u5353\u8d8a\u5b66\u79d1\u9886\u57df\uff0c\u4e3a\u672c\u6e2f\u5927\u4e13\u9662\u6821\u63d0\u4f9b\u4e13\u9879\u62e8\u6b3e\uff0c\u8fdb\u884c\u6709\u5173\u7814\u7a76\u3002\u5728\u5eff\u4e00\u4e2a\u7814\u7a76\u9879\u76ee\u4e2d\uff0c\u7531\u4e2d\u5927\u7814\u7a76\u4eba\u5458\u9886\u5bfc\u7684\u5171\u5360\u516b\u9879\uff1b\u800c\u5728\u6700\u8fd1\u516c\u5e03\u7684\u7b2c\u4e03\u8f6e\u62e8\u6b3e\u7ed3\u679c\u4e2d\uff0c\u5171\u6709\u4e09\u4e2a\u9879\u76ee\u83b7\u9009\uff0c\u4e2d\u5927\u53c2\u4e0e\u4e86\u5168\u90e8\u9879\u76ee\uff0c\u5f53\u4e2d\u300c\u690d\u7269\u4e0e\u73af\u5883\u4e92\u4f5c\u57fa\u56e0\u7ec4\u7814\u7a76\u4e2d\u5fc3\uff1a\u53ef\u6301\u7eed\u519c\u4e1a\u4e0e\u7cae\u98df\u5b89\u5168\u300d\u9879\u76ee\u7531\u4e2d\u5927\u6797\u6c49\u660e\u6559\u6388\u9886\u5bfc\u8fdb\u884c\u3002<\/p><hr 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