2013\u5e74\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b66\u53ca\u533b\u5b66\u5956\u5f97\u4e3b\u6770\u5f17\u7406\uff0e\u970d\u5c14\u6559\u6388\uff08Prof. Jeffrey Hall\uff09\u3001\u8fc8\u514b\u5c14\uff0e\u7f57\u65af\u5df4\u6b8a\uff08Prof. Michael Rosbash\uff09\u53ca\u8fc8\u514b\u5c14\uff0e\u6768\u6559\u6388\uff08Prof. Michael Young\uff09\u6628\u5929\uff089\u670824\u65e5\uff09\u4eb2\u4e34\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\uff08\u4e2d\u5927\uff09\u9038\u592b\u4e66\u9662\uff0c\u5206\u522b\u4ee5\u300c\u4eba\u7686\u5bfb\u68a6\u300d\uff08Everybody’s a Dreamer, and Everybody’s a Star \uff09\u3001\u300c\u663c\u591c\u8282\u5f8b\u7684\u5faa\u73af\u63a7\u5236:\u56de\u671b\u5eff\u8f7d\u4e0e\u5c55\u671b\u672a\u6765\u300d\uff08The Circadian Feedback Loop: Twenty Years and Counting\uff09\u53ca\u300c\u63a7\u5236\u7761\u7720\u53ca\u663c\u591c\u8282\u5f8b\u7684\u57fa\u56e0\u300d\uff08Genes Controlling Sleep and Circadian Rhythms\uff09\u4e3a\u9898\u6f14\u8bb2\uff0c\u5438\u5f15\u8fd1420\u540d\u4e2d\u5927\u53ca\u672c\u5730\u5176\u4ed6\u5927\u5b66\u548c\u4e2d\u5b66\u7684\u5e08\u751f\uff0c\u4ee5\u53ca\u76f8\u5173\u4e13\u5bb6\u5b66\u8005\u51fa\u5e2d\u3002 <\/p>
2013\u5e74\u5ea6\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u5956\u9881\u4e88\u7f05\u56e0\u5dde\u5927\u5b66\u5ba2\u5e2d\u6559\u6388\u6770\u5f17\u7406\uff0e\u970d\u5c14 (Jeffrey C Hall)\u3001\u5e03\u5170\u6234\u65af\u5927\u5b66\u751f\u7269\u5b66\u6559\u6388\u66a8\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240 (HHMI) \u7814\u7a76\u5458\u8fc8\u514b\u5c14\uff0e\u7f57\u65af\u5df4\u6b8a (Michael Rosbash)\u3001\u53ca\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\u5b66\u672f\u4e8b\u52a1\u526f\u6821\u957f\u517c\u6559\u6388\u8fc8\u514b\u5c14\uff0e\u6768 (Michael W Young)\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u53d1\u73b0\u751f\u7269\u663c\u591c\u8282\u5f8b\u7684\u5206\u5b50\u673a\u5236\u3002 <\/p>
\u6240\u6709\u751f\u7269\u90fd\u6709\u4e00\u5b9a\u7684\u8282\u5f8b\uff0c\u4eba\u7c7b\u665a\u95f4\u51fa\u73b0\u7761\u610f\u3001\u98de\u884c\u65f6\u5dee\u5e26\u6765\u56f0\u6270\u3001\u82b1\u6735\u663c\u5f00\u591c\u5408\uff0c\u8fd9\u90fd\u662f\u719f\u6089\u7684\u73b0\u8c61\u3002\u8fd9\u4e9b\u663c\u591c (circadian\u62c9\u4e01\u6587\u300c\u65e5\u5e38\u300d\u7684\u610f\u601d) \u7684\u8282\u5f8b\u867d\u7136\u8033\u719f\u80fd\u8be6\uff0c\u4f46\u751f\u7269\u65f6\u949f\u7684\u672c\u8d28\u4e00\u76f4\u662f\u6666\u6da9\u7684\uff0c\u76f4\u81f3\u5df2\u6545\u7684\u897f\u6469\uff0e\u672c\u6cfd (Seymour Benzer) \u85c9\u8457\u7814\u7a76\u679c\u8747\uff0c\u53d1\u73b0\u4e86\u4e00\u4e2a\u57fa\u56e0\uff0c\u5b83\u7ecf\u8fc7\u53d8\u5f02\uff0c\u53ef\u4ee5\u628a\u751f\u7269\u65f6\u949f\u8c03\u5feb\u3001\u8c03\u6162\u3001\u751a\u81f3\u5173\u6389\u3002\u867d\u7136\u8fd9\u4e2a\u53d1\u73b0\u672c\u8eab\u5e76\u6ca1\u6709\u8bf4\u660e\u751f\u7269\u65f6\u949f\u5982\u4f55\u8fd0\u4f5c\uff0c\u4f46\u5b83\u8e0f\u51fa\u4e86\u7b2c\u4e00\u6b65\uff0c\u4e3a\u7814\u7a76\u63a7\u5236\u663c\u591c\u8282\u5f8b\u7684\u673a\u5236\u6253\u5f00\u4e86\u5927\u95e8\u3002\u4eca\u5c4a\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u5956\u7684\u5f97\u5956\u8005\u6770\u5f17\u7406\uff0e\u970d\u5c14\u3001\u8fc8\u514b\u5c14\uff0e\u7f57\u65af\u5df4\u6b8a\u548c\u8fc8\u514b\u5c14\uff0e\u6768\uff0c\u6cbf\u8457\u8fd9\u4e2a\u65b9\u5411\u5c55\u5f00\u7814\u7a76\uff0c\u5229\u7528\u57fa\u56e0\u53d8\u5f02\u679c\u8747\uff0c\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u5f00\u521b\u6027\u7684\u5b9e\u9a8c\uff0c\u63ed\u793a\u4e86\u64cd\u63a7\u663c\u591c\u8282\u5f8b\u7684\u5206\u5b50\u673a\u5236\u3002\u8fd9\u4e2a\u673a\u5236\u4e0d\u4ec5\u53ea\u5b58\u5728\u4e8e\u679c\u8747\uff0c\u4e5f\u5b58\u5728\u4e8e\u4eba\u7c7b\u3002<\/p>
\u76f8\u5173\u7684\u7814\u7a76\u5de5\u4f5c\u57281984\u5e74\u53d6\u5f97\u7b2c\u4e00\u4e2a\u7a81\u7834\u3002\u5f53\u65f6\uff0c\u5728\u5e03\u5170\u6234\u65af\u5927\u5b66\u7684\u970d\u5c14\u4e0e\u7f57\u65af\u5df4\u6b8a\u7684\u7ec4\u5408\uff0c\u548c\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\u7684\u6768\uff0c\u5206\u522b\u590d\u5236 (\u6216\u79f0\u514b\u9686 clone) \u4e86\u679c\u8747 (Drosophila melanogaster) \u7684\u5468\u671f\u57fa\u56e0 (period gene)\uff0c\u8fd9\u4e2a\u57fa\u56e0\u82e5\u7ecf\u8fc7\u53d8\u5f02\uff0c\u5c31\u53ef\u4ee5\u6539\u53d8\u679c\u8747\u7684\u663c\u591c\u8282\u5f8b\u3002\u8fd9\u4e2a\u53d1\u73b0\u5e26\u6765\u4e86\u970d\u5c14\u4e0e\u7f57\u65af\u5df4\u6b8a\u7ec4\u5408\u7684\u7b2c\u4e8c\u4e2a\u7a81\u7834\u3002\u4ed6\u4eec\u7814\u7a76\u679c\u8747\u8111\u5185\u7531\u5468\u671f\u57fa\u56e0\u6240\u7f16\u7801\u7684\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178 (mRNA) \u548c\u86cb\u767d\uff0c\u53d1\u73b0\u5b83\u4eec\u7684\u6c34\u5e73\u5448\u73b0\u663c\u591c\u8282\u5f8b\u6027\u7684\u53d8\u52a8\u3002\u800c\u4e14\u5468\u671f\u57fa\u56e0\u82e5\u4ea7\u751f\u53d8\u5f02\uff0c\u53ef\u4ee5\u6539\u53d8\u8fd9\u4e9b\u8282\u5f8b\u7684\u6ce2\u52a8\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u63a7\u5236\u751f\u7269\u65f6\u949f\u7684\u57fa\u672c\u673a\u5236\u63d0\u4f9b\u4e86\u7b2c\u4e00\u4e2a\u7ebf\u7d22\ufe55\u5468\u671f\u57fa\u56e0\u7684\u86cb\u767d\u4ea7\u7269\u53ef\u4ee5\u6309\u845724\u5c0f\u65f6\u7684\u5468\u671f\u5faa\u73af\uff0c\u6291\u5236\u81ea\u8eab\u751f\u4ea7\u7684\u53cd\u9988\u8def\u7ebf\u3002\u6768\u4e0e\u970d\u5c14\/\u7f57\u65af\u5df4\u6b8a\u7ec4\u5408\u968f\u540e\u5c55\u5f00\u7814\u7a76\uff0c\u63ed\u793a\u66f4\u591a\u548c\u751f\u7269\u65f6\u949f\u673a\u5236\u6709\u5173\u7684\u57fa\u56e0\uff0c\u5e76\u63d0\u4f9b\u4e86\u8be6\u5c3d\u7684\u4fe1\u606f\uff0c\u8bf4\u660e\u5b83\u4eec\u7684\u4ea7\u7269\u5982\u4f55\u8fd0\u4f5c\uff0c\u600e\u6837\u901a\u8fc7\u5468\u671f\u57fa\u56e0\u7684mRNA\u53ca\u86cb\u767d\u7684\u6c34\u5e73\uff0c\u63a7\u5236\u663c\u591c\u8282\u5f8b\uff0c\u53ca\u65e5\u5149\u5982\u4f55\u91cd\u65b0\u8c03\u6574\u751f\u7269\u65f6\u949f\u3002 <\/p>
\u73b0\u5728\u5df2\u77e5\u970d\u5c14\u3001\u7f57\u65af\u5df4\u6b8a\u548c\u6768\u5728\u679c\u8747\u4e2d\u6240\u53d1\u73b0\u7684\u663c\u591c\u8282\u5f8b\u7684\u57fa\u672c\u673a\u5236\uff0c\u4e5f\u9002\u7528\u4e8e\u5176\u4ed6\u751f\u7269\uff0c\u5305\u62ec\u4eba\u7c7b\u5728\u5185\u3002\u8fd9\u4e9b\u673a\u5236\u548c\u4eba\u7c7b\u75be\u75c5\u4e4b\u95f4\u7684\u5173\u7cfb\u5df2\u5145\u5206\u663e\u793a\u51fa\u6765\u3002\u4f8b\u5982\uff0c\u4eba\u7c7b\u6709\u4e24\u4e2a\u57fa\u56e0\uff0c\u4e0e\u679c\u8747\u7684\u663c\u591c\u8282\u5f8b\u57fa\u56e0\u5bf9\u5e94\uff0c\u800c\u8fd9\u4e24\u4e2a\u57fa\u56e0\u4e0e\u5f71\u54cd\u7761\u7720\u8282\u594f\u7684\u9057\u4f20\u75c5\u5448\u73b0\u76f8\u5173\u3002 <\/p>
\u6709\u5173\u300c\u90b5\u9038\u592b\u5956\u300d<\/u><\/p>
\u300c\u90b5\u9038\u592b\u5956\u300d\u4e3a\u56fd\u9645\u6027\u5956\u9879\uff0c\u5f97\u5956\u4eba\u7686\u6d3b\u8dc3\u4e8e\u5176\u5b66\u672f\u9886\u57df\uff0c\u5728\u5b66\u672f\u7814\u7a76\u3001\u79d1\u5b66\u7814\u7a76\u53ca\u5e94\u7528\u4e0a\u6709\u7a81\u7834\u6027\u7684\u6210\u679c\uff0c\u6216\u5bf9\u6587\u5316\u827a\u672f\u6709\u6770\u51fa\u8d21\u732e\uff0c\u6216\u5728\u5176\u4ed6\u9886\u57df\u6709\u5353\u8d8a\u4e4b\u6210\u5c31\u3002\u8bc4\u9009\u7684\u539f\u5219\u4e3b\u8981\u8003\u8651\u5019\u9009\u4eba\u4e4b\u4e13\u4e1a\u5bf9\u63a8\u52a8\u793e\u4f1a\u8fdb\u6b65\u3001\u63d0\u9ad8\u4eba\u7c7b\u751f\u6d3b\u8d28\u7d20\uff0c\u4ee5\u53ca\u4e30\u5bcc\u4eba\u7c7b\u7cbe\u795e\u6587\u660e\u7684\u8d21\u732e\u3002\u5019\u9009\u4eba\u8fd1\u671f\u7684\u6210\u679c\u5c06\u83b7\u4f18\u5148\u8003\u8651\u3002 <\/p>
\u300c\u90b5\u9038\u592b\u5956\u300d\u4e43\u6309\u90b5\u9038\u592b\u7235\u58eb\u610f\u613f\uff0c\u4e8e2002\u5e7411\u6708\u6210\u7acb\uff0c2004\u5e74\u9881\u53d1\u9996\u5c4a\u5956\u9879\uff0c\u73b0\u4e3a\u7b2c\u5341\u5c4a\u3002\u300c\u90b5\u9038\u592b\u5956\u300d\u8bbe\u6709\u4e09\u4e2a\u5956\u9879\uff0c\u5206\u522b\u4e3a\u5929\u6587\u5b66\u5956\u3001\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u5956\uff0c\u4ee5\u53ca\u6570\u5b66\u79d1\u5b66\u5956\u3002<\/p>","show_as_achievement":false,"achievement_category":[],"show_as_clarification":false,"show_as_announcement":false,"photos":null,"attachments":null,"video_source":null,"video_file":null,"add_play_button":false,"video_caption":"","show_migration":false,"original_id":"1632","photos_original":[{"photo":"52425be692528.jpg","caption":"(\u5de6\u8d77)\u4e2d\u5927\u751f\u7269\u533b\u5b66\u5b66\u9662\u9648\u6587\u4e50\u6559\u6388\u3001\u9038\u592b\u4e66\u9662\u8363\u8a89\u9662\u52a1\u59d4\u5458\u9648\u4f73\u9f10\u6559\u6388\u3001\u4e2d\u5927\u526f\u6821\u957f\u970d\u6cf0\u8f89\u6559\u6388\u30012013\u5e74\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u5956\u5f97\u4e3b\u6770\u5f17\u7406\u2022\u970d\u5c14\u6559\u6388(Prof. Jeffrey C. Hall)\u3001\u8fc8\u514b\u5c14\u2022\u7f57\u65af\u5df4\u6b8a\u6559\u6388(Prof. Michael Rosbash)\u53ca\u8fc8\u514b\u5c14\u2022\u6768\u6559\u6388(Prof. Michael W. Young)\u3001\u9038\u592b\u4e66\u9662\u9662\u957f\u9648\u5fd7\u8f89\u6559\u6388\u3002"},{"photo":"52425be866d81.jpg","caption":"\u6770\u5f17\u7406\u2022\u970d\u5c14\u6559\u6388\u4ee5\u300c\u4eba\u7686\u5bfb\u68a6\u300d\u4e3a\u9898\u53d1\u8868\u6f14\u8bf4\u3002"},{"photo":"52425bea7d28d.jpg","caption":"\u8fc8\u514b\u5c14\u2022\u7f57\u65af\u5df4\u6b8a\u6559\u6388\u4ee5\u300c\u663c\u591c\u8282\u5f8b\u7684\u5faa\u73af\u63a7\u5236\uff1a\u56de\u671b\u5eff\u8f7d\u4e0e\u5c55\u671b\u672a\u6765\u300d\u4e3a\u9898\u53d1\u8868\u6f14\u8bf4\u3002"},{"photo":"52425bec503ff.jpg","caption":"\u8fc8\u514b\u5c14\u2022\u6768\u6559\u6388\u4ee5\u300c\u63a7\u5236\u7761\u7720\u53ca\u663c\u591c\u8282\u5f8b\u7684\u57fa\u56e0\u300d\u4e3a\u9898\u53d1\u8868\u6f14\u8bf4\u3002"},{"photo":"52425bee46afd.jpg","caption":"(\u5de6\u8d77)\u4e2d\u5927\u751f\u7269\u533b\u5b66\u5b66\u9662\u9648\u6587\u4e50\u6559\u6388\u30012013\u5e74\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u5956\u5f97\u4e3b\u6770\u5f17\u7406\u2022\u970d\u5c14\u6559\u6388\u3001\u8fc8\u514b\u5c14\u2022\u7f57\u65af\u5df4\u6b8a\u6559\u6388\u53ca\u8fc8\u514b\u5c14\u2022\u6768\u6559\u6388\u3002"}],"attachments_original":null},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/48627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press"}],"about":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/types\/press"}],"version-history":[{"count":0,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/48627\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/media?parent=48627"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/tags?post=48627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}