{"id":239401,"date":"2026-09-10T09:35:16","date_gmt":"2026-09-10T01:35:16","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/?post_type=press&#038;p=239401"},"modified":"2026-09-10T10:13:34","modified_gmt":"2026-09-10T02:13:34","slug":"cuhk-unlocks-helicobacter-pyloris-self-defence-mechanism-opening-a-new-path-for-gastric-cancer-prevention-and-antibiotic-free-peptic-ulcer-therapies","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/cuhk-unlocks-helicobacter-pyloris-self-defence-mechanism-opening-a-new-path-for-gastric-cancer-prevention-and-antibiotic-free-peptic-ulcer-therapies\/","title":{"rendered":"\u4e2d\u5927\u7834\u89e3\u5e7d\u9580\u87ba\u65cb\u83cc\u300c\u81ea\u6211\u4fdd\u8b77\u300d\u6a5f\u5236 \u9996\u63ed\u93b3\u96e2\u5b50\u7cbe\u6e96\u904b\u8f38\u6a5f\u5236   \u6210\u9632\u6cbb\u80c3\u6f70\u760d\u53ca\u80c3\u764c\u4f73\u97f3"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-239401","press","type-press","status-publish","hentry"],"acf":{"title_alt":"\u4e2d\u5927\u7834\u89e3\u5e7d\u9580\u87ba\u65cb\u83cc\u300c\u81ea\u6211\u4fdd\u8b77\u300d\u6a5f\u5236\r\n\u9996\u63ed\u93b3\u96e2\u5b50\u7cbe\u6e96\u904b\u8f38\u6a5f\u5236   \u6210\u9632\u6cbb\u80c3\u6f70\u760d\u53ca\u80c3\u764c\u4f73\u97f3","sub_title_alt":"","press_date":"20260910","keep":false,"details":"<p>\u5168\u7403\u7d04\u4e00\u534a\u4eba\u53e3\u53d7\u5e7d\u9580\u87ba\u65cb\u83cc\uff08Helicobacter pylori\uff09\u611f\u67d3\uff0c\u9019\u7a2e\u7d30\u83cc\u4e0d\u50c5\u662f\u80c3\u6f70\u760d\u7684\u982d\u865f\u5143\u5147\uff0c\u66f4\u662f\u5f15\u81f4\u80c3\u764c\u7684\u91cd\u8981\u98a8\u96aa\u56e0\u7d20\u3002\u591a\u5e74\u4f86\uff0c\u79d1\u5b78\u5bb6\u4e00\u76f4\u5e0c\u671b\u7834\u89e3\u9019\u9053\u96e3\u984c\uff1a\u5e7d\u9580\u87ba\u65cb\u83cc\u5982\u4f55\u80fd\u5728\u8150\u8755\u6027\u6975\u5f37\u7684\u80c3\u9178\u4e2d\u751f\u5b58\uff0c\u540c\u6642\u5b89\u5168\u9001\u9054\u5177\u6bd2\u6027\u7684\u300c\u93b3\u96e2\u5b50\u300d\u81f3\u5c3f\u7d20\u9176\uff0c\u4ee5\u7dad\u6301\u5176\u6a5f\u5236\u904b\u4f5c\u3002<\/p>\r\n<p>\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u751f\u547d\u79d1\u5b78\u5b78\u9662<strong>\u9ec3\u9326\u6ce2\u6559\u6388<\/strong>\u9818\u5c0e\u7684\u7814\u7a76\u5718\u968a\uff0c\u6210\u529f\u7834\u89e3\u4e86\u9019\u500b\u5fae\u89c0\u4e16\u754c\u7684\u8b0e\u5718\u3002\u7814\u7a76\u5718\u968a\u9996\u6b21\u6355\u6349\u5230\u5e7d\u9580\u87ba\u65cb\u83cc\u9ad4\u5167\u5169\u7a2e\u95dc\u9375\u4f34\u8b77\u86cb\u767d\u8cea\u4ea4\u63a5\u93b3\u96e2\u5b50\u7684\u7cbe\u78ba\u52d5\u614b\u7d50\u69cb\u3002\u7814\u7a76\u6210\u679c\u5df2\u767c\u8868\u65bc\u570b\u969b\u9802\u5c16\u5b78\u8853\u671f\u520a\u300a\u7f8e\u570b\u570b\u5bb6\u79d1\u5b78\u9662\u9662\u520a\u300b\uff08<a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2535662123\">Proceedings of the National Academy of Sciences, PNAS<\/a>\uff09\uff0c\u70ba\u958b\u767c\u6d88\u5316\u6027\u6f70\u760d\u7642\u6cd5\u53ca\u964d\u4f4e\u80c3\u764c\u98a8\u96aa\u5e36\u4f86\u91cd\u8981\u7a81\u7834\u3002<\/p>\r\n<p><strong>\u5e7d\u9580\u87ba\u65cb\u83cc\u6191\u93b3\u96e2\u5b50\u62b5\u79a6\u80c3\u9178\u4fb5\u8972<\/strong><\/p>\r\n<p>\u5e7d\u9580\u87ba\u65cb\u83cc\u4e4b\u6240\u4ee5\u80fd\u5920\u9577\u671f\u5b9a\u6b96\u65bc\u80c3\u90e8\uff0c\u95dc\u9375\u5728\u65bc\u540d\u70ba\u300c\u5c3f\u7d20\u9176\u300d\u7684\u9175\u7d20\u3002\u9019\u7a2e\u9175\u7d20\u80fd\u5c07\u80c3\u88e1\u7684\u5c3f\u7d20\u5206\u89e3\u6210\u6c28\uff0c\u8fc5\u901f\u4e2d\u548c\u80c3\u9178\uff0c\u8b93\u7d30\u83cc\u5b89\u7a69\u5730\u9644\u8457\u5728\u80c3\u9ecf\u819c\u4e0a\u3002\u7136\u800c\uff0c\u6fc0\u6d3b\u5c3f\u7d20\u9176\u9700\u8981\u93b3\u96e2\u5b50\uff0c\u800c\u6e38\u96e2\u7684\u93b3\u5c0d\u7d30\u80de\u4f86\u8aaa\u537b\u662f\u5287\u6bd2\u3002\u56e0\u6b64\uff0c\u5e7d\u9580\u87ba\u65cb\u83cc\u5fc5\u9808\u5728\u907f\u514d\u6bd2\u6027\u50b7\u5bb3\u7684\u540c\u6642\uff0c\u5c07\u93b3\u96e2\u5b50\u9001\u9054\u5c3f\u7d20\u9176\u3002<\/p>\r\n<p><strong>\u9996\u5ea6\u6355\u6349\u93b3\u96e2\u5b50<\/strong><strong>\u300c\u63a5\u529b\u904b\u9001\u300d<\/strong><strong>\u904e\u7a0b<\/strong><\/p>\r\n<p>\u4e2d\u5927\u5718\u968a\u767c\u73fe\uff0c\u5e7d\u9580\u87ba\u65cb\u83cc\u5167\u90e8\u6709\u5169\u7a2e\u5c08\u9580\u8b77\u9001\u91d1\u5c6c\u7684\u86cb\u767d\u8cea\u300c\u91d1\u5c6c\u4f34\u8b77\u86cb\u767d\u300d\uff08Metallochaperones\uff09UreE\u548cUreG\uff0c\u8ca0\u8cac\u904b\u9001\u93b3\u96e2\u5b50\u3002\u5169\u8005\u7336\u5982\u63a5\u529b\u904b\u52d5\u54e1\uff0c\u900f\u904e\u7dca\u5bc6\u914d\u5408\u5b8c\u6210\u93b3\u96e2\u5b50\u7684\u4ea4\u63a5\u3002\u7814\u7a76\u4eba\u54e1\u7d50\u5408X\u5c04\u7dda\u7d50\u6676\u5b78\u8207\u751f\u5316\u5206\u6790\u6280\u8853\uff0c\u6210\u529f\u6355\u6349\u5169\u8005\u7d50\u5408\u6642\u7684\u7acb\u9ad4\u7d50\u69cb\uff0c\u4ee5\u53ca\u93b3\u96e2\u5b50\u300c\u4ea4\u68d2\u300d\u7684\u77ac\u9593\u3002<\/p>\r\n<p>\u7814\u7a76\u986f\u793a\uff0c\u4e00\u7a2e\u540d\u70baGTP\u7684\u80fd\u91cf\u5206\u5b50\u662f\u4fc3\u6210\u5169\u7a2e\u86cb\u767d\u8cea\u6210\u529f\u63a5\u529b\u7684\u95dc\u9375\u3002\u7576GTP\u8207UreG\u7d50\u5408\uff0cUreG\u6703\u6539\u8b8a\u5f62\u72c0\uff0c\u5c07\u81ea\u8eab\u7684\u93b3\u7d50\u5408\u4f4d\u7cbe\u6e96\u5c0d\u63a5UreE\u7684\u4f4d\u7f6e\uff0c\u8b93\u93b3\u5f9eUreE\u8f49\u5165UreG\u3002\u53d6\u5f97\u93b3\u96e2\u5b50\u5f8c\uff0cUreG\u518d\u5ea6\u8b8a\u5f62\u4e26\u5f9e\u8907\u5408\u9ad4\u4e2d\u812b\u8eab\uff0c\u5c07\u93b3\u9001\u5f80\u5c3f\u7d20\u9176\u3002\u6574\u500b\u904e\u7a0b\u7336\u5982\u4e00\u689d\u5bc6\u5c01\u7684\u904b\u8f38\u901a\u9053\uff0c\u80fd\u6709\u6548\u9632\u6b62\u6709\u6bd2\u96e2\u5b50\u5916\u6d29\uff0c\u78ba\u4fdd\u7d30\u83cc\u65e2\u80fd\u7372\u53d6\u5fc5\u9700\u5143\u7d20\uff0c\u53c8\u4e0d\u6703\u53d7\u5230\u6bd2\u6027\u50b7\u5bb3\u3002<\/p>\r\n<p><strong>\u6709\u671b\u958b\u62d3\u6297\u751f\u7d20\u4ee5\u5916\u5168\u65b0\u6cbb\u7642\u7b56\u7565<\/strong><\/p>\r\n<p>\u73fe\u6642\u6cbb\u7642\u5e7d\u9580\u87ba\u65cb\u83cc\u4e3b\u8981\u9760\u6297\u751f\u7d20\u7642\u6cd5\uff0c\u4f46\u81e8\u5e8a\u6297\u751f\u7d20\u8010\u85e5\u6027\u65e5\u76ca\u56b4\u91cd\uff0c\u50b3\u7d71\u7642\u6548\u5927\u4e0d\u5982\u524d\u3002\u662f\u6b21\u7814\u7a76\u63ed\u793a\u4e86\u5e7d\u9580\u87ba\u65cb\u83cc\u5b58\u6d3b\u6240\u5fc5\u9700\u7684\u95dc\u9375\u5206\u5b50\u6b65\u9a5f\uff0c\u70ba\u6a19\u9776\u85e5\u7269\u7814\u767c\u958b\u95e2\u65b0\u9014\u5f91\u3002\u672a\u4f86\uff0c\u7814\u7a76\u4eba\u54e1\u53ea\u9700\u7814\u767c\u963b\u6b62\u5169\u7a2e\u86cb\u767d\u8cea\u4ea4\u63a5\u93b3\u96e2\u5b50\u7684\u6a19\u9776\u85e5\u7269\uff0c\u5c31\u80fd\u7cbe\u6e96\u5207\u65b7\u5e7d\u9580\u87ba\u65cb\u83cc\u7684\u93b3\u96e2\u5b50\u4f9b\u61c9\u93c8\u3002\u5931\u53bb\u93b3\u96e2\u5b50\u7684\u5c3f\u7d20\u9176\u5c07\u7121\u6cd5\u904b\u4f5c\uff0c\u7d30\u83cc\u4fbf\u6703\u5931\u53bb\u4fdd\u8b77\u5c4f\u969c\uff0c\u76f4\u63a5\u88ab\u80c3\u9178\u6d88\u6ec5\u3002\u9019\u7a2e\u5168\u65b0\u7b56\u7565\u7121\u9808\u4f9d\u8cf4\u50b3\u7d71\u6297\u751f\u7d20\uff0c\u6709\u671b\u6839\u6cbb\u6162\u6027\u611f\u67d3\u3001\u6cbb\u7652\u6d88\u5316\u6027\u6f70\u760d\uff0c\u4e26\u5927\u5e45\u964d\u4f4e\u5168\u7403\u80c3\u764c\u98a8\u96aa\u3002<\/p>\r\n<p>\u700f\u89bd\u5b8c\u6574\u8ad6\u6587\uff1a<a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2535662123\">https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2535662123<\/a><\/p>","show_as_achievement":false,"achievement_category":[],"show_as_clarification":false,"show_as_announcement":false,"photos":[{"photo":239404,"caption":"\u9ec3\u9326\u6ce2\u6559\u6388\uff08\u5de6\u56db\uff09\u8207\u5718\u968a\u6210\u54e1\uff08\u5de6\u8d77\uff09\u674e\u5bb6\u660e\u535a\u58eb\u3001\u9673\u5609\u4fca\u3001\u9673\u4fca\u6717\u3001\u8521\u5f64\u548c\u9127\u8335\u8335\u3002"},{"photo":239405,"caption":"\u4e2d\u5927\u751f\u547d\u79d1\u5b78\u5b78\u9662\u9ec3\u9326\u6ce2\u6559\u6388"},{"photo":239406,"caption":"\u535a\u58eb\u7814\u7a76\u751f\u9673\u4fca\u6717\u5728X\u5c04\u7dda\u884d\u5c04\u5100\u4e0a\u5b89\u88dd\u6676\u9ad4\u3002"},{"photo":239407,"caption":"UreE-UreG\u86cb\u767d\u7684\u6676\u9ad4"},{"photo":239409,"caption":"UreE-UreG\u8907\u5408\u9ad4\u7684\u7d50\u69cb"},{"photo":239408,"caption":"\u5e7d\u9580\u87ba\u687f\u83cc\u5229\u7528\u91d1\u5c6c\u4f34\u8b77\u86cb\u767dUreE\u8207UreG\u5c07\u6709\u6bd2\u7684\u93b3\u8f49\u904b\u81f3\u5c3f\u7d20\u9176\u793a\u610f\u5716\u3002"}],"attachments":null,"video_source":"","video_file":"","add_play_button":false,"video_caption":"","show_migration":false,"original_id":0,"photos_original":null,"attachments_original":null},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/239401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press"}],"about":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/types\/press"}],"version-history":[{"count":8,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/239401\/revisions"}],"predecessor-version":[{"id":239482,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/239401\/revisions\/239482"}],"wp:attachment":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/media?parent=239401"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/tags?post=239401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}