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\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u8207\u5168\u7403\u591a\u9593\u764c\u75c7\u4e2d\u5fc3\uff0c\u5171\u540c\u9818\u5c0e\u4e00\u9805\u9577\u9054\u4e03\u5e74\u7684\u5927\u578b\u570b\u969b\u4e09\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u7d50\u679c\u986f\u793a\uff0c\u672a\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u665a\u671fALK\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff0c\u4f7f\u7528\u7b2c\u4e09\u4ee3\u6a19\u9776\u85e5Lorlatinib\u4f5c\u4e00\u7dda\u6cbb\u7642\uff0c\u8d85\u904e\u4e00\u534a\u4e03\u5e74\u9593\u75c5\u60c5\u6c92\u6709\u60e1\u5316\u3002\u6b64\u6210\u679c\u662f\u8fc4\u4eca\u70ba\u6b62\u6240\u6709\u91dd\u5c0d\u665a\u671f\u5be6\u9ad4\u816b\u7624\u7684\u6a19\u9776\u6cbb\u7642\u4e2d\uff0c\u6709\u8a18\u9304\u4ee5\u4f86\u6700\u9577\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u3002\u9019\u610f\u5473\u8457\u96a8\u8457\u91ab\u5b78\u4e0d\u65b7\u9032\u6b65\uff0c\u5c07\u56e0\u67d0\u4e9b\u57fa\u56e0\u7570\u5e38\u800c\u5f15\u8d77\u7684\u665a\u671f\u80ba\u764c\u8f49\u5316\u70ba\u300c\u6162\u6027\u75c5\u300d\uff0c\u8b93\u60a3\u8005\u5f97\u4ee5\u300c\u8207\u75c5\u5171\u5b58\u300d\u7684\u9858\u666f\u6b63\u9010\u6b65\u6210\u70ba\u73fe\u5be6\u3002\u4e2d\u5927\u91ab\u5b78\u9662\u816b\u7624\u5b78\u7cfb\u7cfb\u4e3b\u4efb\u83ab\u6a39\u9326\u6559\u6388<\/strong>\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703\uff082026 ASCO Annual Meeting\uff09\u4e0a\u767c\u8868\u6b64\u9805\u9a5a\u4eba\u767c\u73fe\uff0c\u7814\u7a76\u6210\u679c\u540c\u6642\u520a\u767b\u65bc\u570b\u969b\u6b0a\u5a01\u91ab\u5b78\u671f\u520a\u300a\u816b\u7624\u5b78\u5e74\u9451<\/a>\u300b\uff08Annals of Oncology<\/em>\uff09\u3002<\/p>\r\n

\u80ba\u764c\u662f\u5168\u7403\u6700\u591a\u4eba\u7f79\u60a3\u7684\u764c\u75c7\uff0c\u6bcf\u5e74\u7d04\u6709180\u842c\u4eba\u56e0\u80ba\u764c\u96e2\u4e16\u3002\u5728\u672c\u6e2f\uff0c\u80ba\u764c\u66f4\u662f\u982d\u865f\u764c\u75c7\u6bba\u624b\uff0c\u6bcf\u5e74\u6709\u903e6,000\u5b97\u65b0\u75c7\u3002\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u63a5\u8fd1\u516b\u6210\u70baNSCLC\u60a3\u8005\uff0c\u5176\u4e2d\u7d04\u767e\u5206\u4e4b\u56db\u5c6cALK\u967d\u6027\u500b\u6848\u3002\u80ba\u764c\u8f49\u79fb\u81f3\u8166\u90e8\u5341\u5206\u5e38\u898b\uff0c\u7279\u5225\u662f\u5e36\u6709ALK\u6216EGFR\u57fa\u56e0\u8b8a\u7570\u7684NSCLC\u60a3\u8005\uff0c\u8d85\u904e30%\u6703\u51fa\u73fe\u8166\u8f49\u79fb\u3002\u50b3\u7d71\u653e\u5c04\u6cbb\u7642\u5728\u63a7\u5236\u8166\u8f49\u79fb\u548c\u9577\u671f\u5b58\u6d3b\u65b9\u9762\u6548\u679c\u6709\u9650\u3002<\/p>\r\n

\u8d85\u9577\u300c\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u300d<\/strong><\/p>\r\n

\u6b64\u9805\u7814\u7a76\u5728\u5168\u7403\u591a\u4e2d\u5fc3\u9032\u884c\uff0c\u5171\u6709296\u540d\u5f9e\u672a\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u665a\u671fALK\u967d\u6027NSCLC\u60a3\u8005\u53c3\u8207\uff0c\u96a8\u6a5f\u5206\u70ba\u5169\u7d44\uff1a149\u4eba\u63a5\u53d7\u7b2c\u4e09\u4ee3\u6a19\u9776\u85e5Lorlatinib\uff0c147\u4eba\u63a5\u53d7\u7b2c\u4e00\u4ee3\u6a19\u9776\u85e5Crizotinib\u3002\u7814\u7a76\u7d50\u679c\u5982\u4e0b\uff1a<\/p>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
\r\n

\u8a55\u4f30\u6307\u6a19<\/strong><\/p>\r\n<\/td>\r\n

\r\n

Lorlatinib <\/strong>\u7d44<\/strong> (149<\/strong>\u4eba<\/strong>)<\/strong><\/p>\r\n<\/td>\r\n

\r\n

\u5c0d\u7167\u7d44\uff1a<\/strong>Crizotinib<\/strong>\u7d44<\/strong> \u00a0<\/strong>(147<\/strong>\u4eba<\/strong>)<\/strong><\/p>\r\n<\/td>\r\n<\/tr>\r\n

\r\n

\u4e2d\u4f4d\u7121\u60e1\u5316\u5b58\u6d3b\u671f<\/p>\r\n<\/td>\r\n

\r\n

\u5c1a\u672a\u9054\u5230 \uff08\u5df2\u8d85\u904e\u4e03\u5e74\uff09<\/p>\r\n<\/td>\r\n

\r\n

9.1 \u500b\u6708<\/p>\r\n<\/td>\r\n<\/tr>\r\n

\r\n

\u4e03\u5e74\u7121\u60e1\u5316\u5b58\u6d3b\u7387<\/p>\r\n<\/td>\r\n

\r\n

55%<\/p>\r\n<\/td>\r\n

\r\n

3%<\/p>\r\n<\/td>\r\n<\/tr>\r\n

\r\n

\u4e2d\u4f4d\u9871\u5167\u7121\u60e1\u5316\u6642\u9593<\/p>\r\n<\/td>\r\n

\r\n

\u5c1a\u672a\u9054\u5230<\/p>\r\n<\/td>\r\n

\r\n

16.4 \u500b\u6708<\/p>\r\n<\/td>\r\n<\/tr>\r\n

\r\n

\u4e03\u5e74\u7121\u9871\u5167\u60e1\u5316\u6a5f\u7387
\r\n\uff08\u6240\u6709\u60a3\u8005\uff09<\/p>\r\n<\/td>\r\n

\r\n

92%<\/p>\r\n<\/td>\r\n

\r\n

16%<\/p>\r\n<\/td>\r\n<\/tr>\r\n

\r\n

\u4e03\u5e74\u7121\u9871\u5167\u60e1\u5316\u6a5f\u7387
\r\n\uff08\u60a3\u8005\u521d\u59cb\u7121\u8166\u8f49\u79fb\uff09<\/p>\r\n<\/td>\r\n

\r\n

96%<\/p>\r\n<\/td>\r\n

\r\n

22%<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n

\u9577\u9054\u4e03\u5e74\u7684\u8ffd\u8e64\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u4f7f\u7528Lorlatinib\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u7684\u60a3\u8005\uff0c\u5176\u4e2d\u4f4d\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u300c\u5c1a\u672a\u9054\u5230\u300d\uff0c\u610f\u5473\u8457\u8d85\u904e\u4e00\u534a\u7684\u60a3\u8005\u5728\u7528\u85e5\u4e03\u5e74\u5f8c\uff0c\u75c5\u60c5\u4f9d\u7136\u7a69\u5b9a\uff0c\u6c92\u6709\u60e1\u5316\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u50b3\u7d71\u4e00\u7dda\u85e5\u7269Crizotinib\u7d44\u7684\u4e2d\u4f4d\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u50c5\u70ba9.1\u500b\u6708\uff0c\u5169\u8005\u76f8\u5dee\u4e5d\u500d\u3002Lorlatinib\u7d44\u8f03\u5c0d\u7167\u7d44\u7684\u75c5\u60c5\u60e1\u5316\u6216\u6b7b\u4ea1\u98a8\u96aa\u5927\u5e45\u964d\u4f4e\u8d85\u904e80%\u3002\u5982\u679c\u60a3\u8005\u5728\u63a5\u53d7Lorlatinib\u6cbb\u7642\u7684\u999624\u500b\u6708\u5167\u75c5\u60c5\u6c92\u6709\u60e1\u5316\uff0c\u4ed6\u5011\u5230\u7b2c\u4e03\u5e74\u6642\u4f9d\u7136\u4fdd\u6301\u7121\u60e1\u5316\u7684\u6a5f\u7387\u9ad8\u905479%\u3002\u9019\u8868\u660e\u53ea\u8981\u65e9\u671f\u628a\u75c5\u60c5\u63a7\u5236\u5f97\u597d\uff0c\u60a3\u8005\u6975\u6709\u53ef\u80fd\u9577\u6642\u9593\u4e0d\u6703\u60e1\u5316\u3002<\/p>\r\n

\u6709\u6548\u9810\u9632\u8166\u8f49\u79fb\u4e26\u8b49\u9577\u671f\u670d\u7528\u5b89\u5168<\/strong><\/p>\r\n

\u8166\u8f49\u79fb\u662fALK\u967d\u6027\u80ba\u764c\u60a3\u8005\u6700\u5e38\u9762\u81e8\u7684\u5a01\u8105\u4e4b\u4e00\uff0c\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\u3002Lorlatinib\u88ab\u8b49\u5be6\u5177\u6709\u6975\u5f37\u7684\u8840\u8166\u5c4f\u969c[1]<\/a>\u7a7f\u900f\u80fd\u529b\uff0c\u6574\u9ad4\u800c\u8a00\uff0c\u60a3\u8005\u5728\u6cbb\u7642\u8d85\u904e30\u500b\u6708\u5f8c\u6c92\u6709\u51fa\u73fe\u65b0\u7684\u8166\u90e8\u60e1\u5316\u75c5\u4f8b\uff0c\u4e03\u5e74\u7121\u9871\u5167\u60e1\u5316\u6a5f\u7387\u9ad8\u905492%\uff0c\u662f\u5c0d\u7167\u7d44\u7684\u516d\u500d\u3002\u800c\u521d\u59cb\u5df2\u6709\u8166\u8f49\u79fb\u7684\u60a3\u8005\uff0c\u5176\u4e03\u5e74\u7121\u9871\u5167\u60e1\u5316\u7684\u6a5f\u7387\u5247\u70ba83%\uff1bLorlatinib\u66f4\u6210\u529f\u4ee496%\u539f\u672c\u6c92\u6709\u8166\u8f49\u79fb\u7684\u60a3\u8005\u5728\u4e03\u5e74\u5167\u6c92\u6709\u51fa\u73fe\u8166\u8f49\u79fb\uff0c\u5e7e\u4e4e\u5b8c\u5168\u9810\u9632\u4e86\u65b0\u767c\u8166\u8f49\u79fb\u3002<\/p>\r\n

\u4e2d\u5927\u91ab\u5b78\u9662\u816b\u7624\u5b78\u7cfb\u52a9\u7406\u6559\u6388\u674e\u5146\u6f84\u91ab\u751f<\/strong>\u6307\u51fa\uff1a\u300c\u8166\u8f49\u79fb\u4e00\u76f4\u56b4\u91cd\u5f71\u97ff\u80ba\u764c\u60a3\u8005\u9577\u671f\u751f\u5b58\u548c\u751f\u6d3b\u8cea\u7d20\u3002\u662f\u6b21\u7814\u7a76\u986f\u793a\uff0cLorlatinib\u5728\u63a7\u5236\u5df2\u51fa\u73fe\u8166\u75c5\u8b8a\u548c\u9810\u9632\u65b0\u767c\u8166\u8f49\u79fb\u65b9\u9762\u5c55\u73fe\u51fa\u9a5a\u4eba\u7684\u4fdd\u8b77\u6548\u679c\uff0c\u751a\u81f3\u5728\u6cbb\u764230\u500b\u6708\u5f8c\u5be6\u73fe\u4e86\u9871\u5167\u75c5\u60c5\u7121\u60e1\u5316\u3002\u9019\u7a2e\u6301\u7e8c\u7684\u8166\u90e8\u4fdd\u8b77\u529b\uff0c\u662f\u5176\u6210\u70ba\u4e00\u7dda\u6cbb\u7642\u7684\u6838\u5fc3\u512a\u52e2\u3002\u300d<\/p>\r\n

\u7814\u7a76\u7d50\u679c\u540c\u6642\u986f\u793a\uff0c\u60a3\u8005\u9577\u671f\u670d\u7528Lorlatinib\u6c92\u6709\u51fa\u73fe\u65b0\u7684\u6216\u66f4\u56b4\u91cd\u7684\u526f\u4f5c\u7528\u3002\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u4e3b\u8981\u70ba\u9ad8\u81bd\u56fa\u9187\u3001\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u3001\u9ad4\u91cd\u589e\u52a0\u53ca\u8a8d\u77e5\u529f\u80fd\u53d7\u640d\u3002\u9019\u4e9b\u60c5\u6cc1\u901a\u904e\u8abf\u6574\u85e5\u7269\u5291\u91cf\u4fbf\u53ef\u4ee5\u8655\u7406\u3002\u5373\u4f7f\u56e0\u526f\u4f5c\u7528\u9069\u7576\u964d\u4f4e\u7528\u85e5\u5291\u91cf\uff0c\u4e5f\u4e0d\u5f71\u97ff\u7642\u6548\u3002<\/p>\r\n

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