{"id":232844,"date":"2026-01-02T11:50:59","date_gmt":"2026-01-02T03:50:59","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/?post_type=press&#038;p=232844"},"modified":"2026-01-02T11:50:36","modified_gmt":"2026-01-02T03:50:36","slug":"cuhk-unveils-the-worlds-first-cd4-treg-cell-heart-regeneration-mechanism-offering-a-new-target-for-heart-repair-treatment","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/cuhk-unveils-the-worlds-first-cd4-treg-cell-heart-regeneration-mechanism-offering-a-new-target-for-heart-repair-treatment\/","title":{"rendered":"\u4e2d\u5927\u5168\u7403\u9996\u6b21\u63ed\u793aCD4+ Treg\u7d30\u80de\u555f\u52d5\u5fc3\u81df\u518d\u751f\u6a5f\u5236 \u70ba\u5fc3\u81df\u4fee\u5fa9\u6cbb\u7642\u5e36\u4f86\u65b0\u9776\u9ede"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-232844","press","type-press","status-publish","hentry"],"acf":{"title_alt":"\u4e2d\u5927\u5168\u7403\u9996\u6b21\u63ed\u793aCD4+ Treg\u7d30\u80de\u555f\u52d5\u5fc3\u81df\u518d\u751f\u6a5f\u5236\r\n\u70ba\u5fc3\u81df\u4fee\u5fa9\u6cbb\u7642\u5e36\u4f86\u65b0\u9776\u9ede","sub_title_alt":"","press_date":"20260102","keep":false,"details":"<p>\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u5168\u7403\u9996\u6b21\u63ed\u793a\uff0c\u514d\u75ab\u7cfb\u7d71\u4e2d\u7684CD4<sup>+<\/sup> Treg\u7d30\u80de\uff08CD4<sup>+<\/sup> FOXP3<sup>+<\/sup> \u8abf\u7bc0\u6027T\u7d30\u80de\uff09\u80fd\u7cbe\u6e96\u8abf\u63a7\u65b0\u751f\u5152\u5fc3\u81df\u518d\u751f\u95dc\u9375MRG15\uff0c\u4e26\u767c\u73fe\u5176\u4fc3\u9032\u5fc3\u81df\u767c\u80b2\u53ca\u4fee\u5fa9\u7684\u6a5f\u5236\u3002\u6b64\u7a81\u7834\u6027\u7814\u7a76\u70ba\u5fc3\u81df\u518d\u751f\u91ab\u5b78\u63d0\u4f9b\u5168\u65b0\u9776\u9ede\u8207\u6cbb\u7642\u7b56\u7565\uff0c\u6709\u671b\u89e3\u6c7a\u5fc3\u81df\u53d7\u640d\u5f8c\u7121\u6cd5\u81ea\u884c\u4fee\u5fa9\u7684\u96e3\u984c\uff0c\u60e0\u53ca\u4e2d\u570b\u53ca\u5168\u7403\u5fc3\u808c\u6897\u585e\u8207\u5fc3\u81df\u8870\u7aed\u60a3\u8005\u3002\u7814\u7a76\u7d50\u679c\u5df2\u65bc\u570b\u969b\u9802\u5c16\u5fc3\u8840\u7ba1\u9818\u57df\u671f\u520a\u300a<em><a href=\"https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.125.073890\">Circulation<\/a><\/em>\u300b\u767c\u8868\u3002<\/p>\r\n<p><strong>\u4e2d\u5927\u767c\u73fe<\/strong><strong>CD4<sup>+<\/sup> Treg<\/strong><strong>\u7d30\u80de\u53ef\u4fc3\u9032\u5fc3\u81df\u7d30\u80de\u518d\u751f<\/strong><strong> \u00a0<\/strong><\/p>\r\n<p>\u5fc3\u81df\u662f\u4eba\u9ad4\u6700\u91cd\u8981\u7684\u5668\u5b98\u4e4b\u4e00\uff0c\u6210\u5e74\u4eba\u7684\u5fc3\u808c\u7d30\u80de\u4e00\u65e6\u53d7\u640d\uff0c\u4fbf\u7121\u6cd5\u900f\u904e\u518d\u751f\u75ca\u7652\uff0c\u4f46\u65b0\u751f\u5152\u7684\u5fc3\u81df\u5373\u4f7f\u53d7\u640d\uff0c\u4e5f\u6709\u77ed\u66ab\u800c\u986f\u8457\u7684\u4fee\u5fa9\u53ca\u518d\u751f\u80fd\u529b\uff0c\u60df\u6b64\u80fd\u529b\u6703\u96a8\u8457\u5e74\u9f61\u589e\u9577\u800c\u6d88\u5931\uff0c\u9019\u4e5f\u662f\u5fc3\u808c\u6897\u585e\u3001\u5fc3\u81df\u8870\u7aed\u53ca\u4e2d\u98a8\u7b49\u5fc3\u8840\u7ba1\u75be\u75c5\u6210\u70ba\u5168\u7403\u6700\u81f4\u547d\u75be\u75c5\u7684\u4e3b\u56e0\u3002\u4e16\u754c\u885e\u751f\u7d44\u7e54\u6307\u51fa\uff0c\u6bcf\u5e74\u8fd1\u4e8c\u5343\u842c\u4eba\u56e0\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\uff1b\u4e2d\u570b\u75be\u75c5\u9810\u9632\u63a7\u5236\u4e2d\u5fc3\u6578\u64da\u4ea6\u986f\u793a\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u7d04\u4f54\u4e2d\u570b\u5167\u5730\u6b7b\u4ea1\u500b\u6848\u8fd1\u4e94\u6210\u3002\u672c\u6e2f\u65b9\u9762\uff0c\u6bcf\u516d\u5b97\u6b7b\u4ea1\u500b\u6848\u4e2d\uff0c\u6709\u4e00\u5b97\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u6216\u4e2d\u98a8\u76f8\u95dc<a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a>\u3002<\/p>\r\n<p>\u70ba\u63a2\u7d22\u65b0\u751f\u5152\u77ed\u66ab\u7684\u5fc3\u808c\u4fee\u5fa9\u80fd\u529b\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u6cbb\u7642\u7684\u95dc\u4fc2\uff0c\u4e2d\u5927\u91ab\u5b78\u9662<strong>\u5442\u611b\u862d\u6559\u6388<\/strong>\u7684\u7814\u7a76\u5718\u968a\u591a\u5e74\u4f86\u81f4\u529b\u7814\u7a76\u4e00\u7a2e\u540d\u70baCD4<sup>+<\/sup> Treg\u7d30\u80de\u7684\u514d\u75ab\u7d30\u80de\uff0c\u5b83\u662fT\u7d30\u80de\u7684\u4e9e\u7fa4\uff0c\u80fd\u8abf\u7bc0\u514d\u75ab\u7cfb\u7d71\u30022025\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u76f8\u95dc\u7814\u7a76\u63ed\u793aTreg\u7d30\u80de\u80fd\u901a\u904e\u8abf\u63a7\u904e\u5ea6\u514d\u75ab\u53cd\u61c9\uff0c\u6cbb\u7642\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\uff1b\u800c\u4e2d\u5927\u5718\u968a\u65bc2019\u5e74\u5728\u9802\u5c16\u671f\u520a\u300a<em>Theranostics<\/em>\u300b\u767c\u8868\u7684\u7814\u7a76\u4e2d\u63ed\u793a\uff0cTreg\u7d30\u80de\u64c1\u6709\u8abf\u63a7\u514d\u75ab\u7cfb\u7d71\u4ee5\u5916\u7684\u529f\u80fd\u3002\u8a72\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u65b0\u751f\u5c0f\u9f20\u7684\u5fc3\u81df\u53d7\u640d\u5f8c\uff0cCD4<sup>+<\/sup> Treg\u7d30\u80de\u6703\u88ab\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u65c1\u5206\u6ccc\u6a5f\u5236\u5206\u6ccc\u56e0\u5b50\uff0c\u76f4\u63a5\u4fc3\u9032\u5fc3\u808c\u7d30\u80de\u589e\u6b96\u3002\u6b64\u767c\u73fe\u70ba\u958b\u767c\u4fc3\u9032\u5fc3\u81df\u4fee\u5fa9\u53ca\u518d\u751f\u7684\u5d84\u65b0\u7642\u6cd5\u63d0\u4f9b\u91cd\u8981\u7dda\u7d22\uff0c\u60df\u76f8\u95dc\u7684\u5177\u9ad4\u4f5c\u7528\u6a5f\u5236\u672a\u660e\u3002<\/p>\r\n<p><strong>MRG15<\/strong><strong>\u662f\u555f\u52d5\u5fc3\u81df\u518d\u751f\u7684\u95dc\u9375<\/strong><\/p>\r\n<p>\u7814\u7a76\u5718\u968a\u7d93\u904e\u516d\u5e74\u7684\u7814\u7a76\uff0c\u7d42\u65bc\u5728\u300a<em>Circulation<\/em>\u300b\u767c\u8868\u7684\u7814\u7a76\u4e2d\u63ed\u958bCD4<sup>+<\/sup> Treg\u7d30\u80de\u8abf\u63a7\u65b0\u751f\u671f\u5fc3\u81df\u77ed\u66ab\u518d\u751f\u6a5f\u5236\u7684\u5967\u79d8\u3002\u5be6\u9a57\u7d50\u679c\u8b49\u5be6\uff0cCD4<sup>+<\/sup> Treg\u7d30\u80de\u80fd\u63a7\u5236\u4e00\u7a2e\u540d\u70baMRG15\u7684\u67d3\u8272\u8cea\u8abf\u63a7\u86cb\u767d\uff0cMRG15\u5728\u65b0\u751f\u5152\u5fc3\u808c\u7d30\u80de\u4e2d\u8655\u65bc\u9ad8\u8868\u9054\u6c34\u5e73\uff0c\u4e26\u6703\u96a8\u8457\u5fc3\u81df\u767c\u80b2\u6210\u719f\u800c\u986f\u8457\u4e0b\u964d\u3002<\/p>\r\n<p>\u70ba\u9032\u4e00\u6b65\u63a2\u7d22MRG15\u5728\u518d\u751f\u6a5f\u5236\u4e2d\u7684\u4f5c\u7528\uff0c\u7814\u7a76\u5718\u968a\u63a1\u7528\u300c\u57fa\u56e0\u5254\u9664\u5c0f\u9f20\u6a21\u578b\u300d\uff0c\u300c\u5254\u9664\u300d\u65b0\u751f\u5c0f\u9f20\u5fc3\u81df\u7d30\u80de\u5167\u7684MRG15\uff0c\u8a55\u4f30\u5fc3\u81df\u524d\u9a45\u7d30\u80de\u53ca\u5fc3\u808c\u7d30\u80de\u518d\u751f\u80fd\u529b\u7684\u8b8a\u5316\uff1b\u53e6\u901a\u904e\u4e00\u7a2e\u57fa\u56e0\u8f09\u9ad4\u91cd\u65b0\u6fc0\u6d3bMRG15\uff0c\u89c0\u5bdf\u5176\u5fc3\u81df\u7d30\u80de\u662f\u5426\u6703\u518d\u751f\u53ca\u4fee\u5fa9\u3002<\/p>\r\n<p>\u7d93\u904e\u986f\u5fae\u93e1\u75c5\u7406\u5b78\u89c0\u5bdf\u3001\u7d30\u80de\u589e\u6b96\u5206\u6790\u3001\u8d85\u8072\u6ce2\u5fc3\u81df\u529f\u80fd\u6aa2\u6e2c\u7b49\u591a\u9805\u5206\u6790\uff0c\u7814\u7a76\u4eba\u54e1\u767c\u73fe\u9019\u4e9b\u65b0\u751f\u5c0f\u9f20\u7684MRG15\u88ab\u522a\u9664\u5f8c\uff0c\u5fc3\u808c\u7d30\u80de\u589e\u6b96\u6e1b\u5c11\uff0c\u518d\u751f\u80fd\u529b\u6703\u986f\u8457\u6e1b\u5f31\u3002\u540c\u6642\uff0c\u7576CD4<sup>+<\/sup> Treg\u7d30\u80de\u88ab\u6e05\u9664\u6642\uff0c\u5fc3\u81df\u518d\u751f\u80fd\u529b\u540c\u6a23\u53d7\u5230\u6291\u5236\uff1b\u800c\u5728\u900f\u904e\u57fa\u56e0\u8f09\u9ad4\u91cd\u65b0\u6fc0\u6d3bMRG15\u5f8c\uff0c\u5fc3\u81df\u80fd\u5920\u6062\u5fa9\u5927\u90e8\u5206\u518d\u751f\u529f\u80fd\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0cCD4<sup>+<\/sup> Treg\u7d30\u80de\u8207MRG15\u4e4b\u9593\u5b58\u5728\u5bc6\u5207\u7684\u529f\u80fd\u806f\u7e6b\uff1aCD4<sup>+<\/sup> Treg\u7d30\u80de\u900f\u904e\u8abf\u63a7MRG15\u7684\u8868\u9054\u4f86\u4fc3\u9032\u5fc3\u808c\u7d30\u80de\u589e\u6b96\u8207\u5fc3\u81df\u518d\u751f\u3002\u63db\u8a00\u4e4b\uff0cMRG15\u662fCD4<sup>+<\/sup> Treg\u7d30\u80de\u767c\u63ee\u4f5c\u7528\u7684\u91cd\u8981\u5206\u5b50\u4e2d\u4ecb\uff0c\u800c\u5169\u8005\u5728\u5fc3\u81df\u4fee\u5fa9\u904e\u7a0b\u4e2d\u7f3a\u4e00\u4e0d\u53ef\u3002<\/p>\r\n<p><strong>\u65b0\u751f<\/strong><strong>CD4<sup>+<\/sup> Treg<\/strong><strong>\u7d30\u80de\u80fd\u5354\u8abf\u5fc3\u81df\u4fee\u5fa9\u518d\u751f\u6a5f\u5236<\/strong><\/p>\r\n<p>\u7814\u7a76\u4eba\u54e1\u66f4\u6210\u529f\u63ed\u793aCD4<sup>+<\/sup> Treg\u7d30\u80de\u5982\u4f55\u7cbe\u6e96\u8abf\u63a7MRG15\u7684\u8def\u5f91\uff0c\u555f\u52d5\u518d\u751f\u6a5f\u5236\u3002\u5be6\u9a57\u7d50\u679c\u986f\u793a\uff0c\u5fc3\u81df\u53d7\u640d\u5f8c\u4e00\u5468\u5167\uff0c\u65b0\u751f\u5c0f\u9f20\u7684CD4<sup>+<\/sup> Treg\u7d30\u80de\u80fd\u5206\u6ccc\u7279\u6b8a\u56e0\u5b50\uff0c\u7cbe\u6e96\u5730\u8a98\u5c0eMRG15\u8207TIP60\u3001p300\u548cRNA\u805a\u5408\u9176II\u7b49\u86cb\u767d\u8cea\u7d44\u6210\u8907\u5408\u9ad4\uff0c\u6fc0\u6d3b\u7d30\u80de\u9031\u671f\u86cb\u767dD1\uff08\u53c8\u7a31\u70baCcnd1\uff09<em>\uff0c<\/em>\u4ea6\u5373\u662f\u63a7\u5236\u7d30\u80de\u5206\u88c2\u7684\u57fa\u56e0\uff0c\u5f9e\u800c\u4fc3\u9032\u5fc3\u808c\u7d30\u80de\u589e\u6b96\u53ca\u4fee\u5fa9\u3002<\/p>\r\n<p>\u7814\u7a76\u7b2c\u4e00\u4f5c\u8005\u3001\u4e2d\u5927\u91ab\u5b78\u9662\u5316\u5b78\u75c5\u7406\u5b78\u7cfb\u535a\u58eb\u7814\u7a76\u751f<strong>\u4faf\u694a\u5cf0<\/strong>\u5148\u751f\u6307\u51fa\uff1a\u300c\u662f\u6b21\u7814\u7a76\u9996\u6b21\u95e1\u660eCD4<sup>+<\/sup> Treg\u7d30\u80de\u5982\u4f55\u900f\u904e\u8a98\u5c0eMRG15\uff0c\u806f\u540cTIP60\u8207CCND1\uff0c\u555f\u52d5\u65b0\u751f\u5fc3\u808c\u7d30\u80de\u7684\u518d\u751f\u6a5f\u5236\u3002\u6211\u5011\u66f4\u767c\u73fe\u6210\u5e74CD4<sup>+<\/sup> Treg\u7d30\u80de\u7f3a\u4e4f\u9019\u7a2e\u8a98\u5c0e\u80fd\u529b\uff0c\u9019\u610f\u5473\u8457CD4<sup>+<\/sup> Treg\u7d30\u80de\u7684\u6578\u91cf\u3001\u529f\u80fd\u53ca\u5206\u5e03\u4ee5\u53ca\u57fa\u56e0\u8868\u9054\u7684\u8abf\u7bc0\u65b9\u5f0f\u6216\u8a31\u662f\u6210\u5e74\u5fc3\u81df\u5931\u53bb\u518d\u751f\u6f5b\u529b\u7684\u95dc\u9375\uff0c\u4e5f\u662f\u65e5\u5f8c\u9032\u4e00\u6b65\u63a2\u8a0e\u514d\u75ab\u8abf\u63a7\u8207\u5fc3\u81df\u518d\u751f\u7684\u7814\u7a76\u65b9\u5411\u3002\u300d<\/p>\r\n<p>\u7814\u7a76\u901a\u8a0a\u4f5c\u8005\u3001\u4e2d\u5927\u91ab\u5b78\u9662\u5316\u5b78\u75c5\u7406\u5b78\u7cfb<strong>\u5442\u611b\u862d\u6559\u6388<\/strong>\u8868\u793a\uff1a\u300c\u9019\u6b21\u6210\u529f\u5f9e\u514d\u75ab\u5b78\u7684\u89d2\u5ea6\u7834\u89e3\u65b0\u751f\u5152\u5fc3\u81df\u81ea\u6211\u4fee\u5fa9\u7684\u300e\u9470\u5319\u300f\u53ca\u6a5f\u5236\uff0c\u52a0\u6df1\u4e86\u5168\u7403\u91ab\u5b78\u754c\u5c0dCD4<sup>+<\/sup> Treg\u7d30\u80de\u7684\u7406\u89e3\u3002\u6b64\u514d\u75ab\u7d30\u80de\u4e0d\u4f46\u662f\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u300e\u5b88\u8b77\u8005\u300f\uff0c\u66f4\u5728\u5fc3\u81df\u4fee\u5fa9\u904e\u7a0b\u4e2d\u626e\u6f14\u300e\u7dad\u4fee\u54e1\u300f\u7684\u89d2\u8272\u3002\u6211\u5011\u4e0b\u4e00\u6b65\u5c07\u7814\u7a76\u5982\u4f55\u5c07\u9019\u500b\u7368\u7279\u7684\u6a5f\u5236\u8f49\u5316\u70ba\u81e8\u5e8a\u6cbb\u7642\u7b56\u7565\uff0c\u671f\u671b\u70ba\u5fc3\u808c\u6897\u585e\u53ca\u5fc3\u81df\u8870\u7aed\u60a3\u8005\u958b\u5275\u5d84\u65b0\u7684\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u3002\u300d<\/p>\r\n<p><a href=\"#_ftnref1\" name=\"_ftn1\">[1]<\/a> 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