{"id":227815,"date":"2025-08-11T11:37:17","date_gmt":"2025-08-11T03:37:17","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/?post_type=press&#038;p=227815"},"modified":"2026-01-28T17:28:13","modified_gmt":"2026-01-28T09:28:13","slug":"cu-medicine-reveals-dietary-interventions-with-fermentable-carbohydrates-boosts-metformin-efficacy-in-type-2-diabetes-prevention","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/cu-medicine-reveals-dietary-interventions-with-fermentable-carbohydrates-boosts-metformin-efficacy-in-type-2-diabetes-prevention\/","title":{"rendered":"\u4e2d\u5927\u91ab\u5b78\u9662\u63ed\u793a\u53ef\u767c\u9175\u78b3\u6c34\u5316\u5408\u7269\u98f2\u98df\u4ecb\u5165\u6cbb\u7642 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name=\"_ftnref1\">[1]<\/a>\uff09\u80fd\u986f\u8457\u63d0\u5347\u4e8c\u7532\u96d9\u80cd\uff08metformin\uff09\u7684\u7642\u6548\uff0c\u6b64\u85e5\u662f\u9810\u9632\u7cd6\u5c3f\u75c5\u524d\u671f\u60a3\u8005\u767c\u5c55\u70ba2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u4e00\u7dda\u85e5\u7269\u3002\u9019\u7a2e\u4ee5\u98df\u7269\u914d\u5408\u85e5\u7269\u7684\u6cbb\u7642\u6709\u52a9\u964d\u4f4e\u9910\u5f8c\u8840\u7cd6\u6c34\u5e73\u4e26\u6539\u5584\u8178\u9053\u5fae\u751f\u614b\uff0c\u7814\u7a76\u7d50\u679c\u8b49\u660e\u4ee5\u66f4\u500b\u4eba\u5316\u7684\u71df\u990a\u65b9\u6848\u914d\u5408\u85e5\u7269\u4ecb\u5165\u7684\u91cd\u8981\u6027\u3002\u662f\u6b21\u7814\u7a76\u7531\u4e2d\u5927\u91ab\u5b78\u9662\u806f\u540c\u4e2d\u5927\u91ab\u5b78\u9662\u85e5\u5291\u5b78\u9662\u8207\u6fb3\u6d32\u8499\u7d0d\u58eb\u5927\u5b78\u5408\u4f5c\u9032\u884c\uff0c\u5176\u7814\u7a76\u7d50\u679c\u5df2\u520a\u767b\u65bc\u570b\u969b\u77e5\u540d\u671f\u520a\u300a<em><a href=\"https:\/\/rdcu.be\/eyET4\">Nature Metabolism<\/a><\/em>\u300b\u3002<\/p>\r\n<p>\u80f0\u5cf6\u7d20\u662f\u8abf\u7bc0\u8840\u7cd6\u6c34\u5e73\u7684\u95dc\u9375\u3002\u60a3\u6709\u7cd6\u5c3f\u75c5\u524d\u671f\u4eba\u58eb\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u53ca\u80f0\u5cf6\u7d20\u4f5c\u7528\u5747\u53d7\u640d\u3002\u5728\u4e2d\u570b\uff0c\u6bcf\u5e74\u6bcf\u4e94\u540d\u7cd6\u5c3f\u75c5\u524d\u671f\u60a3\u8005\u4e2d\uff0c\u4fbf\u6709\u4e00\u4f4d\u6703\u767c\u5c55\u70ba2\u578b\u7cd6\u5c3f\u75c5<a href=\"#_ftn2\" name=\"_ftnref2\">[2]<\/a>\u3002\u4e8c\u7532\u96d9\u80cd\u662f\u9810\u9632\u7cd6\u5c3f\u75c5\u7684\u4e00\u7dda\u85e5\u7269\uff0c\u60df\u6b64\u85e5\u7d93\u5e38\u5f15\u767c\u8178\u80c3\u9053\u526f\u4f5c\u7528\u3002\u81e8\u5e8a\u8a66\u9a57\u986f\u793a\uff0c\u5927\u6982\u6bcf100\u540d\u4e2d\u570b\u7cd6\u5c3f\u75c5\u524d\u671f\u60a3\u8005\u4fbf\u670915\u540d\u5728\u670d\u7528\u4e8c\u7532\u96d9\u80cd\u5f8c\u51fa\u73fe\u5641\u5fc3\u3001\u8179\u8139\u6216\u8179\u7009\u7b49\u8178\u80c3\u4e0d\u9069\u75c7\u72c0<a href=\"#_ftn2\" name=\"_ftnref2\">[2]<\/a>\u3002\u96d6\u7136\u4e8c\u7532\u96d9\u80cd\u5728\u5ef6\u7de9\u6216\u9810\u96322\u578b\u7cd6\u5c3f\u75c5\u65b9\u9762\u5177\u5099\u78ba\u5207\u7642\u6548\uff0c\u9019\u4e9b\u526f\u4f5c\u7528\u53ef\u80fd\u5f71\u97ff\u60a3\u8005\u7684\u670d\u85e5\u4f9d\u5f9e\u6027\uff0c\u56e0\u6b64\u91ab\u5b78\u754c\u6025\u9700\u5236\u5b9a\u7b56\u7565\u4ee5\u63d0\u5347\u60a3\u8005\u5c0d\u4e8c\u7532\u96d9\u80cd\u7684\u8010\u53d7\u6027\u53ca\u4f9d\u5f9e\u6027\u3002<\/p>\r\n<p>\u662f\u6b21\u7814\u7a76\u7531\u4e2d\u5927\u91ab\u5b78\u9662\u7814\u7a76\u5718\u968a\u4e3b\u5c0e\uff0c\u62db\u52df\u4e8626 \u4f4d\u5e74\u9f61\u4ecb\u4e4e 48 \u81f3 60 \u6b72\u7684\u7cd6\u5c3f\u75c5\u524d\u671f\u60a3\u8005\u53c3\u8207\u4e00\u9805\u96d9\u76f2\u3001\u96a8\u6a5f\u3001\u5206\u70ba\u5169\u500b\u968e\u6bb5\u7684\u4ea4\u53c9\u98f2\u98df\u63a7\u5236\u8a66\u9a57\u3002\u53c3\u52a0\u8005\u7372\u96a8\u6a5f\u5206\u914d\u81f3\u5169\u500b\u70ba\u671f10\u5929\u3001\u71b1\u91cf\u76f8\u540c\u7684\u98f2\u98df\u4ecb\u5165\u968e\u6bb5\uff0c\u5305\u62ec\u4e2d\u7b49\u4efd\u91cfFODMAP\u98f2\u98df\uff08\u6bcf\u65e5\u651d\u53d612 \u514b\uff09\u53ca\u4f4e\u4efd\u91cfFODMAP\u98f2\u98df\uff08\u6bcf\u65e5\u651d\u53d62 \u514b\uff09\u968e\u6bb5\u3002\u6240\u6709\u53c3\u52a0\u8005\u5728\u6bcf\u500b\u98f2\u98df\u968e\u6bb5\u7684\u6700\u5f8c\u4e94\u5929\u670d\u7528\u4e8c\u7532\u96d9\u80cd\uff0c\u4e26\u63a5\u53d7\u76f2\u6cd5\u6301\u7e8c\u8840\u7cd6\u76e3\u6e2c\uff0c\u4ee5\u8a18\u9304\u8840\u7cd6\u8b8a\u5316\u7684\u5dee\u7570\u3002<\/p>\r\n<p>\u7814\u7a76\u8a66\u9a57\u767c\u73fe\uff0c\u53c3\u52a0\u8005\u651d\u53d6\u4e2d\u7b49\u4efd\u91cf\u7684FODMAP\u4e26\u670d\u7528\u4e8c\u7532\u96d9\u80cd\uff08M-M\u4ecb\u5165\uff09\u6642\uff0c\u5065\u5eb7\u6307\u6a19\u8f03\u651d\u53d6\u4f4e\u4efd\u91cfFODMAP\u4e26\u670d\u7528\u4e8c\u7532\u96d9\u80cd\uff08L-M\u4ecb\u5165\uff09\u6642\u66f4\u70ba\u7406\u60f3\uff0c\u800c\u9019\u4e9b\u6307\u6a19\u7684\u6539\u5584\u8207\u7e3d\u71b1\u91cf\u651d\u53d6\u91cf\u7684\u8b8a\u5316\u7121\u95dc\uff1a \u00a0<\/p>\r\n<ul>\r\n\t<li><strong>\u63d0\u5347\u8840\u7cd6\u63a7\u5236\u80fd\u529b\uff1a<\/strong>M-M \u4ecb\u5165\u5f8c\u7684\u9910\u5f8c\u8840\u7cd6\u4e0b\u8dcc21%\uff0c \u800cL-M \u4ecb\u5165\u5f8c\u7684\u8dcc\u5e45\u53ea\u670912%\uff0c\u986f\u793aFODMAP\u651d\u53d6\u91cf\u589e\u52a0\uff0c\u4e8c\u7532\u96d9\u80cd\u7684\u964d\u7cd6\u6548\u679c\u4ea6\u96a8\u4e4b\u589e\u5f37\uff1b<\/li>\r\n\t<li><strong>\u589e\u5f37\u80f0\u5cf6\u7d20\u53cd\u61c9\uff1a<\/strong>\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\uff08GLP-1\uff09\u662f\u4e00\u7a2e\u8178\u9053\u6fc0\u7d20\uff0c\u6709\u52a9\u63d0\u5347\u9910\u5f8c\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\u53ca\u589e\u5f37\u98fd\u8db3\u611f\u3002\u9032\u884cM-M \u4ecb\u5165\u5f8c\uff0c\u9910\u5f8c\u5f8c\u671fGLP-1\u5206\u6ccc\u91cf\u662f\u57fa\u7dda\u6c34\u5e73\u7684\u4e09\u500d\uff0c\u5347\u5e45\u8f03L-M\u4ecb\u5165\u968e\u6bb5\u9ad898%\u3002\u9910\u5f8c\u5f8c\u671f\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\u4ea6\u8f03L-M\u4ecb\u5165\u968e\u6bb5\u9ad880%\u3002L-M\u4ecb\u5165\u5f8c\u7684\u6fc0\u7d20\u6c34\u5e73\u4e26\u7121\u592a\u5927\u8b8a\u5316\uff1b<\/li>\r\n\t<li><strong>\u8178\u9053\u5fae\u751f\u614b\u7372\u5927\u5e45\u6539\u5584\uff1a<\/strong> M-M \u4ecb\u5165\u5f8c\uff0c\u88fd\u9020\u77ed\u93c8\u8102\u80aa\u9178\u7684\u8178\u9053\u83cc<em>Butyricimonas virosa<\/em> \u542b\u91cf\u662f L-M \u4ecb\u5165\u5f8c\u7684\u5169\u500d\uff0c\u6709\u52a9\u6539\u5584\u63a7\u5236\u8840\u7cd6\u7684\u80fd\u529b\u53ca\u6e1b\u5c11\u5168\u8eab\u708e\u75c7\uff1b<\/li>\r\n\t<li><strong>\u5c0d\u4e8c\u7532\u96d9\u80cd\u4e0d\u8010\u53d7\u7684\u9810\u6e2c\u751f\u7269\u6a19\u8a18\uff1a<\/strong>\u7814\u7a76\u986f\u793a\uff0c\u5c0d\u4e8c\u7532\u96d9\u80cd\u4e0d\u8010\u53d7\u8005\u7684Dorea formicigenerans \u7684\u57fa\u7dda\u6c34\u5e73\u8f03\u5c0d\u4e8c\u7532\u96d9\u80cd\u8010\u53d7\u8005\u70ba\u9ad8\uff0c\u986f\u793a\u8a72\u83cc\u7a2e\u5177\u6f5b\u529b\u6210\u70ba\u751f\u7269\u6a19\u8a18\uff0c\u4ee5\u8b58\u5225\u5bb9\u6613\u56e0\u670d\u7528\u4e8c\u7532\u96d9\u80cd\u800c\u51fa\u73fe\u8178\u80c3\u9053\u526f\u4f5c\u7528\u7684\u4eba\u58eb\uff0c\u6709\u52a9\u63d0\u4f9b\u66f4\u500b\u4eba\u5316\u7684\u6cbb\u7642\u3002<\/li>\r\n<\/ul>\r\n<p>\u662f\u6b21\u7814\u7a76\u7b2c\u4e00\u4f5c\u8005\u3001\u4e2d\u5927\u91ab\u5b78\u9662\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1<strong>\u6731\u6d77\u661f\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u300c\u6211\u5011\u7684\u7814\u7a76\u63ed\u793a\u651d\u53d6\u4e2d\u7b49\u4efd\u91cf\u7684FODMAP\u8f03\u4f4e\u4efd\u91cf\u7684FODMAP\u66f4\u80fd\u5e6b\u52a9\u60a3\u8005\u8abf\u7bc0\u8178\u9053\u5fae\u751f\u614b\uff0c\u5f9e\u800c\u589e\u5f37\u4e8c\u7532\u96d9\u80cd\u4f5c\u70ba\u9810\u96322\u578b\u7cd6\u5c3f\u75c5\u4e00\u7dda\u85e5\u7269\u7684\u964d\u8840\u7cd6\u6548\u679c\u3002\u300d<\/p>\r\n<p>\u901a\u8a0a\u4f5c\u8005\u3001\u4e2d\u5927\u91ab\u5b78\u9662\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u526f\u6559\u6388\uff08\u81e8\u5e8a\uff09<strong>\u5468\u6021\u541b\u91ab\u751f<\/strong>\u88dc\u5145\uff1a\u300c\u672c\u5730\u7684\u4e2d\u7b49\u4efd\u91cfFODMAP 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