{"id":227292,"date":"2025-07-28T13:12:46","date_gmt":"2025-07-28T05:12:46","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/?post_type=press&#038;p=227292"},"modified":"2025-07-28T13:12:46","modified_gmt":"2025-07-28T05:12:46","slug":"cuhk-unveils-a-new-gene-therapy-targeting-parkinsons-disease","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/cuhk-unveils-a-new-gene-therapy-targeting-parkinsons-disease\/","title":{"rendered":"\u4e2d\u5927\u7814\u767c\u65b0\u578b\u57fa\u56e0\u7642\u6cd5 \u6709\u52a9\u7de9\u6e1b\u67cf\u91d1\u905c\u75c5\u5fb5\u72c0"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-227292","press","type-press","status-publish","hentry"],"acf":{"title_alt":"\u4e2d\u5927\u7814\u767c\u65b0\u578b\u57fa\u56e0\u7642\u6cd5 \u6709\u52a9\u7de9\u6e1b\u67cf\u91d1\u905c\u75c5\u5fb5\u72c0","sub_title_alt":"","press_date":"20250728","keep":false,"details":"<p>\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u751f\u547d\u79d1\u5b78\u5b78\u9662<strong>\u9673\u6587\u535a\u6559\u6388<\/strong>\u5718\u968a\u6700\u8fd1\u6210\u529f\u7814\u767c\u4e86\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u67cf\u91d1\u905c\u75c5\u7684\u65b0\u578b\u57fa\u56e0\u7642\u6cd5\u3002\u7814\u7a76\u5718\u968a\u5728\u67cf\u91d1\u905c\u75c5\u52d5\u7269\u6a21\u578b\u6e2c\u8a66\u4e2d\uff0c\u5411\u76ee\u6a19\u8166\u5340\u55ae\u6b21\u6ce8\u5c04\u52a0\u5165\u5176\u5c08\u5229\u6cbb\u7642\u80bd\u7684\u91cd\u7d44\u817a\u76f8\u95dc\u75c5\u6bd2\uff08rAAV\uff09\uff0c\u53ef\u7de9\u6e1b\u8166\u9000\u5316\u75c5\u8b8a\u4e26\u6539\u5584\u5fb5\u72c0\u3002\u76f8\u95dc\u7814\u7a76\u6210\u679c\u5df2\u767c\u8868\u65bc\u7d30\u80de\u8207\u57fa\u56e0\u6cbb\u7642\u9818\u57df\u6b0a\u5a01\u671f\u520a\u300a<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1525001625002795?via%3Dihub\">\u5206\u5b50\u6cbb\u7642<\/a>\u300b\u3002<\/p>\r\n<p><strong>\u67cf\u91d1\u905c\u75c5\u6cbb\u7642\u65b0\u65b9\u5411<\/strong><\/p>\r\n<p>\u67cf\u91d1\u905c\u75c5\u662f\u7b2c\u4e8c\u5e38\u898b\u7684\u8166\u9000\u5316\u75be\u75c5\uff0c\u5f71\u97ff\u5168\u7403\u6578\u767e\u842c\u4eba\u3002\u60a3\u8005\u4e0d\u50c5\u51fa\u73fe\u9707\u986b\u3001\u52d5\u4f5c\u9072\u7de9\u548c\u808c\u8089\u50f5\u786c\u7b49\u904b\u52d5\u5fb5\u72c0\uff0c\u9084\u4f34\u96a8\u7761\u7720\u969c\u7919\u3001\u60c5\u7dd2\u7570\u5e38\u7b49\u975e\u904b\u52d5\u5fb5\u72c0\u3002\u73fe\u6642\u5c0d\u65bc\u67cf\u91d1\u905c\u75c7\u7684\u81e8\u5e8a\u6cbb\u7642\u50c5\u80fd\u7de9\u89e3\u5fb5\u72c0\uff0c\u672a\u6709\u6839\u6cbb\u65b9\u6cd5\uff0c\u6545\u9700\u7814\u767c\u80fd\u5920\u5ef6\u7de9\u6216\u963b\u6b62\u8166\u9000\u5316\u75c5\u60c5\u60e1\u5316\u7684\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\uff08Disease-modifying therapies\uff09\u3002<\/p>\r\n<p>\u76ee\u524d\uff0c\u67cf\u91d1\u905c\u75c5\u7684\u767c\u75c5\u6a5f\u5236\u5c1a\u672a\u5b8c\u5168\u95e1\u660e\uff0c\u4f46\u666e\u904d\u8a8d\u70ba\u8207\u5927\u8166\u4e2d\u4e00\u7a2e\u5167\u5728\u7121\u5e8f\u86cb\u767d\u03b1-\u7a81\u89f8\u6838\u86cb\u767d\u7684\u7570\u5e38\u805a\u96c6\u6709\u95dc\u3002\u7531\u65bc\u8a72\u86cb\u767d\u672c\u8eab\u7121\u56fa\u5b9a\u7d50\u69cb\u4e14\u805a\u96c6\u904e\u7a0b\u8907\u96dc\uff0c\u5176\u9776\u5411\u6cbb\u7642\u4e00\u76f4\u9762\u81e8\u6311\u6230\u3002\u9673\u6559\u6388\u5718\u968a\u6b64\u524d\u7814\u767c\u4e86\u4e00\u7a2eSUMO1\u86cb\u767d\u884d\u751f\u7684\u5c0f\u5206\u5b50\u80bd\uff0c\u80fd\u7279\u7570\u6027\u7d50\u5408\u03b1-\u7a81\u89f8\u6838\u86cb\u767d\u55ae\u9ad4\uff0c\u5f9e\u6e90\u982d\u963b\u65b7\u5176\u805a\u96c6\u7d1a\u806f\u53cd\u61c9\u4e26\u767c\u63ee\u795e\u7d93\u4fdd\u8b77\u4f5c\u7528\u3002\u540c\u6642\uff0cSUMO1\u4f5c\u70ba\u4e00\u7a2e\u4eba\u9ad4\u5929\u7136\u5b58\u5728\u7684\u86cb\u767d\uff0c\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\u548c\u8f03\u9ad8\u7684\u5b89\u5168\u6027\uff0c\u6709\u52a9\u63d0\u5347SUMO1\u6cbb\u7642\u80bd\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002<\/p>\r\n<p><strong>\u5728\u67cf\u91d1\u905c\u75c5\u81e8\u5e8a\u524d\u52d5\u7269\u6a21\u578b\u4e2d\u7642\u6548\u986f\u8457<\/strong><\/p>\r\n<p>\u5718\u968a\u7684\u6700\u65b0\u7814\u7a76\u9a57\u8b49\u4e86\u6539\u826f\u5f8c\u7684SUMO1\u6cbb\u7642\u80bd\u5728\u795e\u7d93\u7d30\u80de\u6a21\u578b\u548c\u67cf\u91d1\u905c\u75c5\u7684\u8f49\u57fa\u56e0\u679c\u8805\u6a21\u578b\u4e2d\u7684\u7642\u6548\u3002\u96a8\u5f8c\uff0c\u5718\u968a\u63a1\u7528\u81e8\u5e8a\u57fa\u56e0\u6cbb\u7642\u5e38\u7528\u7684\u905e\u9001\u8f09\u9ad4rAAV\uff0c\u4ee5\u55ae\u6b21\u9871\u5167\u6ce8\u5c04\u7684\u65b9\u5f0f\u8d8a\u904e\u8840\u8166\u5c4f\u969c\uff0c\u5c07\u6539\u826f\u7684SUMO1\u6cbb\u7642\u80bd\u76f4\u63a5\u905e\u9001\u81f3\u60a3\u6709\u67cf\u91d1\u905c\u75c5\u5c0f\u9f20\u7684\u76ee\u6a19\u8166\u5340\u4e26\u6301\u7e8c\u8868\u9054\u3002\u5be6\u9a57\u7d50\u679c\u986f\u793a\uff0c\u6cbb\u7642\u80bd\u7d93rAAV\u6301\u7e8c\u8868\u9054\u53ef\u5f9e\u6839\u6e90\u963b\u65b7\u03b1-\u7a81\u89f8\u6838\u86cb\u767d\u7684\u805a\u96c6\uff0c\u986f\u8457\u6539\u5584\u4e86\u67cf\u91d1\u905c\u75c5\u5c0f\u9f20\u8207\u75be\u75c5\u76f8\u95dc\u7684\u904b\u52d5\u529f\u80fd\u969c\u7919\uff0c\u4e26\u6709\u52a9\u4fdd\u8b77\u5176\u8166\u4e2d\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\u3002<\/p>\r\n<p><strong>\u9673\u6559\u6388<\/strong>\u8868\u793a\uff1a\u300c\u9019\u9805\u65b0\u578b\u57fa\u56e0\u7642\u6cd5\u6a19\u8a8c\u8457\u67cf\u91d1\u905c\u75c5\u6cbb\u7642\u7684\u91cd\u8981\u7a81\u7834\u3002\u5728\u5c0f\u9f20\u6a21\u578b\u6e2c\u8a66\u4e2d\uff0c\u6211\u5011\u89c0\u5bdf\u5230\u55ae\u6b21\u6ce8\u5c04\u6cbb\u7642\u6027rAAV\u53ef\u6709\u6548\u4fdd\u8b77\u591a\u5df4\u80fa\u80fd\u795e\u7d93\u5143\uff0c\u4e26\u6e1b\u7de9\u904b\u52d5\u529f\u80fd\u9000\u5316\u3002\u6b64\u7642\u6cd5\u6709\u671b\u5ef6\u7de9\u67cf\u91d1\u905c\u75c5\u60a3\u8005\u7684\u75c5\u60c5\u60e1\u5316\u3002\u6211\u5011\u6b63\u7a4d\u6975\u63a8\u9032\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\uff0c\u671f\u671b\u80fd\u958b\u767c\u60e0\u53ca\u5168\u7403\u60a3\u8005\u7684\u6cbb\u7642\u65b9\u6848\u3002\u300d<\/p>\r\n<p>\u5728\u9999\u6e2f\u5275\u65b0\u79d1\u6280\u7f72\u300c\u5927\u5b78\u79d1\u6280\u521d\u5275\u4f01\u696d\u8cc7\u52a9\u8a08\u5283\u300d\u7684\u652f\u6301\u4e0b\uff0c\u9673\u6559\u6388\u5718\u968a\u5df2\u6210\u7acb\u521d\u5275\u516c\u53f8SUMO Therapeutics\uff0c\u5c08\u6ce8\u958b\u767c\u91dd\u5c0d\u67cf\u91d1\u905c\u75c5\u548c\u8def\u6613\u6c0f\u9ad4\u8a8d\u77e5\u969c\u7919\u75c7\u7b49\u8207\u03b1-\u7a81\u89f8\u6838\u86cb\u767d\u805a\u96c6\u76f8\u95dc\u75be\u75c5\u7684\u5275\u65b0\u7642\u6cd5\u3002\u9019\u4e00\u8209\u63aa\u5f70\u986f\u4e86\u5718\u968a\u5c07\u524d\u6cbf\u79d1\u7814\u6210\u679c\u8f49\u5316\u70ba\u5168\u7403\u5065\u5eb7\u6311\u6230\u89e3\u6c7a\u65b9\u6848\u7684\u6c7a\u5fc3\u3002<\/p>","show_as_achievement":false,"achievement_category":[],"show_as_clarification":false,"show_as_announcement":false,"photos":[{"photo":227294,"caption":"\u7814\u7a76\u5718\u968a\u90e8\u5206\u6210\u54e1\uff1a\uff08\u5de6\u8d77\uff09\u9673\u6d69\u7136\u6559\u6388\u3001\u674e\u660e\u540d\u535a\u58eb\u3001\u9673\u6587\u535a\u6559\u6388\u3001\u6881\u5146\u8f1d\u535a\u58eb\u3001\u9ece\u6587\u96c5\u5c0f\u59d0\u53caSuresh Kanna Murugappan\u535a\u58eb\u3002"},{"photo":227300,"caption":"\u6cbb\u7642\u7d44\u5c0f\u9f20\u5728\u52fb\u901f\u8f49\u68d2\u5be6\u9a57\u4e2d\u8868\u73fe\u51fa\u660e\u986f\u66f4\u9577\u7684\u8dcc\u843d\u6f5b\u4f0f\u671f\uff0c\u8b49\u660e\u6539\u5584\u4e86\u5176\u904b\u52d5\u5354\u8abf\u80fd\u529b\u548c\u5e73\u8861\u80fd\u529b\uff08\u5de6\u5716\uff09\u3002\u6cbb\u7642\u7d44\u5c0f\u9f20\u5728\u5713\u6876\u6e2c\u8a66\u4e2d\u76f4\u7acb\u78b0\u58c1\u6b21\u6578\u6709\u6240\u63d0\u5347\uff0c\u8868\u793a\u6709\u52a9\u4fdd\u8b77\u5176\u611f\u89ba\u904b\u52d5\u529f\u80fd\uff08\u53f3\u5716\uff09\u3002"}],"attachments":null,"video_source":"","video_file":227250,"add_play_button":false,"video_caption":"\u6b64\u5f71\u7247\u986f\u793a\u4e86\u672a\u63a5\u53d7\u6cbb\u7642\u8207\u63a5\u53d7\u6cbb\u7642\u7684\u67cf\u91d1\u905c\u75c7\u5c0f\u9f20\u5728\u52fb\u901f\u8f49\u68d2\u5be6\u9a57\u53ca\u5713\u7b52\u6e2c\u8a66\u4e2d\u7684\u8868\u73fe\u5dee\u7570\u3002\u6cbb\u7642\u7d44\u5c0f\u9f20\u8868\u73fe\u51fa\u66f4\u9577\u7684\u8dcc\u843d\u6f5b\u4f0f\u671f\uff0c\u4e14\u76f4\u7acb\u78b0\u58c1\u6b21\u6578\u660e\u986f\u589e\u52a0\u3002","show_migration":false,"original_id":0,"photos_original":null,"attachments_original":null},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/227292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press"}],"about":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/types\/press"}],"version-history":[{"count":3,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/227292\/revisions"}],"predecessor-version":[{"id":227304,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/227292\/revisions\/227304"}],"wp:attachment":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/media?parent=227292"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/tags?post=227292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}