{"id":225153,"date":"2025-05-19T17:39:57","date_gmt":"2025-05-19T09:39:57","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/?post_type=press&#038;p=225153"},"modified":"2025-05-19T17:39:57","modified_gmt":"2025-05-19T09:39:57","slug":"cuhk-led-multinational-study-shows-new-china-developed-cancer-drug-d3s-001-is-effective-in-treating-solid-tumours-including-lung-colorectal-and-pancreatic-cancer","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/cuhk-led-multinational-study-shows-new-china-developed-cancer-drug-d3s-001-is-effective-in-treating-solid-tumours-including-lung-colorectal-and-pancreatic-cancer\/","title":{"rendered":"\u4e2d\u5927\u9818\u5c0e\u570b\u969b\u7814\u7a76\u8b49\u5be6\u5167\u5730\u7814\u767c\u85e5\u7269D3S-001\u6297\u764c\u6210\u6548 \u6709\u6548\u6cbb\u7642\u80ba\u764c\u3001\u7d50\u76f4\u8178\u764c\u3001\u80f0\u817a\u764c\u7b49\u591a\u7a2e\u5be6\u9ad4\u816b\u7624"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-225153","press","type-press","status-publish","hentry"],"acf":{"title_alt":"\u4e2d\u5927\u9818\u5c0e\u570b\u969b\u7814\u7a76\u8b49\u5be6\u5167\u5730\u7814\u767c\u85e5\u7269D3S-001\u6297\u764c\u6210\u6548\r\n\u6709\u6548\u6cbb\u7642\u80ba\u764c\u3001\u7d50\u76f4\u8178\u764c\u3001\u80f0\u817a\u764c\u7b49\u591a\u7a2e\u5be6\u9ad4\u816b\u7624","sub_title_alt":"","press_date":"20250519","keep":false,"details":"<p>\u7531\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u9818\u5c0e\u7684\u8de8\u570b\u5718\u968a\uff0c\u9032\u884c\u4e86\u4e00\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u8b49\u5be6\u5167\u5730\u7814\u767c\u7684\u65b0\u4e00\u4ee3KRAS-G12C\u6291\u5236\u5291D3S-001\uff0c\u5728\u6cbb\u7642\u591a\u7a2e\u56e0KRAS-G12C\u57fa\u56e0\u7a81\u8b8a\u800c\u5f15\u8d77\u7684\u5be6\u9ad4\u816b\u7624\u4e0a\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u7684\u6297\u816b\u7624\u6d3b\u6027\u3001\u5b89\u5168\u6027\u53ca\u514b\u670d\u6297\u85e5\u6027\u7684\u6548\u80fd\uff0c\u70baKRAS-G12C\u57fa\u56e0\u7a81\u8b8a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7642\u5e0c\u671b\u3002\u6709\u95dc\u7814\u7a76\u7d50\u679c\u5df2\u65bc\u9802\u5c16\u91ab\u5b78\u671f\u520a<strong>\u300a\u81ea\u7136\u91ab\u5b78\u300b<\/strong>\u767c\u8868\u3002<\/p>\r\n<p><strong>KRAS<\/strong><strong>\u57fa\u56e0\u7a81\u8b8a\u8207\u591a\u7a2e\u764c\u75c7\u5bc6\u5207\u76f8\u95dc<\/strong><\/p>\r\n<p>KRAS\u57fa\u56e0\u7a81\u8b8a\u662f\u591a\u7a2e\u5be6\u9ad4\u816b\u7624\uff08\u5982\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u7d50\u76f4\u8178\u764c\u3001\u80f0\u81df\u764c\uff09\u7684\u5e38\u898b\u81f4\u764c\u56e0\u7d20\u3002KRAS-G12C\u70ba\u6700\u5e38\u898b\u7684KRAS\u57fa\u56e0\u7a81\u8b8a\u4e9e\u578b\uff0c\u7d04\u670911-15%\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u6709\u6b64\u57fa\u56e0\u7a81\u8b8a\u3002\u904e\u53bb\uff0c\u91dd\u5c0dKRAS-G12C\u57fa\u56e0\u7a81\u8b8a\u7684\u6a19\u9776\u85e5\u7269\u7642\u6548\u6709\u9650\uff0c\u5c24\u5176\u5728\u7d50\u76f4\u8178\u764c\u4e2d\u9700\u7d50\u5408\u5176\u4ed6\u85e5\u7269\uff08\u5982\u6297EGFR\u6297\u9ad4\uff09\u624d\u80fd\u63d0\u5347\u6cbb\u7642\u6548\u679c\u3002\u56e0\u6b64\uff0c\u8fd1\u5e74\u6709\u5167\u5730\u7684\u751f\u7269\u79d1\u6280\u5718\u968a\u7814\u767c\u51fa\u65b0\u4e00\u4ee3KRAS-G12C\u6291\u5236\u5291D3S-001\uff0c\u65e8\u5728\u63d0\u9ad8\u6a19\u9776\u6291\u5236\u6548\u7387\u4e26\u514b\u670d\u764c\u75c7\u6cbb\u7642\u8010\u85e5\u6027\u3002<\/p>\r\n<p>\u674e\u6a39\u82ac\u91ab\u5b78\u57fa\u91d1\u816b\u7624\u5b78\u6559\u6388\u3001\u4e2d\u5927\u91ab\u5b78\u9662\u526f\u9662\u9577\uff08\u79d1\u7814\u8f49\u5316\u53ca\u5275\u696d\uff09\u53ca\u816b\u7624\u5b78\u7cfb\u7cfb\u4e3b\u4efb<strong>\u83ab\u6a39\u9326\u6559\u6388<\/strong>\uff0c\u9818\u5c0e\u4f86\u81ea\u5357\u97d3\u3001\u6fb3\u6d32\u3001\u7f8e\u570b\u3001\u4e2d\u570b\u5167\u5730\u53ca\u9999\u6e2f\u7684\u8de8\u570b\u5718\u968a\uff0c\u5c31D3S-001\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u7d50\u76f4\u8178\u764c\u3001\u80f0\u81df\u764c\u9032\u884c\u4e00\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u70ba\u5169\u500b\u968e\u6bb5\uff1a<\/p>\r\n<ul>\r\n\t<li>\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff08Phase 1a\uff09\uff1a42\u540d\u5e36\u6709KRAS-G12C\u57fa\u56e0\u7a81\u8b8a\u7684\u665a\u671f\u5be6\u9ad4\u816b\u7624\u60a3\u8005\u53c3\u8207\uff0c\u63a5\u53d7D3S-001\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u6cbb\u7642\uff0c\u5291\u91cf\u7bc4\u570d\u70ba50mg\u81f3900mg\uff0c\u4ee5\u6e2c\u8a66D3S-001\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6700\u4f73\u5291\u91cf\u3002<\/li>\r\n\t<li>\u5291\u91cf\u64f4\u5c55\u968e\u6bb5\uff08Phase 1b\uff09\uff1a20\u540d\u66fe\u63a5\u53d7\u904eKRAS-G12C\u6291\u5236\u5291\u6cbb\u7642\u4f46\u75c5\u60c5\u60e1\u5316\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u53c3\u8207\uff0c\u4e26\u63a5\u53d7D3S-001\u6cbb\u7642\uff0c\u4ee5\u8a55\u4f30D3S-001\u7684\u7642\u6548\u3002<\/li>\r\n<\/ul>\r\n<p><strong>D3S-001<\/strong><strong>\u5c55\u73fe\u986f\u8457\u7684\u6297\u816b\u7624\u6d3b\u6027<\/strong><strong>\u3001<\/strong><strong>\u5b89\u5168\u6027\u53ca\u8010\u85e5\u6027<\/strong><\/p>\r\n<p>\u7814\u7a76\u7d50\u679c\u767c\u73fe\uff0cD3S-001\u6574\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u53c3\u8207\u7814\u7a76\u60a3\u8005\u6700\u5e38\u51fa\u73fe\u7684\u526f\u4f5c\u7528\u5305\u62ec\u5641\u5fc3\u548c\u8179\u7009\uff0c\u4f46\u7a0b\u5ea6\u50c5\u70ba\u8f15\u81f3\u4e2d\u5ea6\u3002\u6578\u64da\u986f\u793a\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d600\u6beb\u514b\u4ee5\u4e0b\u7684\u5291\u91cf\uff0c\u8840\u6f3f\u4e2d\u7684\u85e5\u7269\u6fc3\u5ea6\u5df2\u8db3\u4ee5\u5b8c\u5168\u6291\u5236KRAS-G12C\u7a81\u8b8a\u86cb\u767d\u3002<\/p>\r\n<p>\u5728\u9996\u6b21\u63a5\u53d7KRAS\u6291\u5236\u5291\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u89c0\u5bdf\u5230D3S-001\u986f\u8457\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u6301\u4e45\u7684\u7642\u6548\u3002\u9019\u7d44\u672a\u63a5\u53d7\u904eKRAS\u6291\u5236\u5291\u7684\u60a3\u8005\u5728\u9032\u884cD3S-001\u6cbb\u7642\u5f8c\uff0c\u6574\u9ad4\u5ba2\u89c0\u7de9\u89e3\u7387\uff08Objective Response Rate, ORR\uff09\u8d85\u904e70%\uff0c\u53cd\u6620\u6b64\u7d44\u5225\u4e2d\u6709\u591a\u65bc\u4e03\u6210\u60a3\u8005\u7684\u816b\u7624\u6709\u660e\u986f\u7e2e\u5c0f\u6216\u5b8c\u5168\u6d88\u5931\uff1b\u800c\u7528\u4ee5\u8a55\u4f30\u6cbb\u7642\u5f8c\u6c92\u6709\u51fa\u73fe\u60e1\u5316\u7684\u75be\u75c5\u63a7\u5236\u7387\uff08Disease Control Rate, DCR\uff09\u5247\u905497%\uff1b\u516d\u500b\u6708\u7121\u60e1\u5316\u5b58\u6d3b\u7387\u4ea6\u905470%\u3002<\/p>\r\n<p>\u81f3\u65bc\u66fe\u63a5\u53d7\u904eKRAS\u6291\u5236\u5291\u7684\u60a3\u8005\u4e2d\uff0cD3S-001\u7684\u6574\u9ad4\u5ba2\u89c0\u7de9\u89e3\u7387\u70ba30%\uff1b\u75be\u75c5\u63a7\u5236\u7387\u5247\u70ba80%\uff0c\u986f\u793aD3S-001\u5c0d\u8010\u85e5\u60a3\u8005\u4ecd\u6709\u4e00\u5b9a\u6548\u679c\u3002<\/p>\r\n<p>\u90e8\u5206\u8166\u8f49\u79fb\u60a3\u8005\u7d93\u6cbb\u7642\u5f8c\uff0c\u8166\u5167\u816b\u7624\u7e2e\u5c0f\u6216\u75c5\u60c5\u8da8\u7a69\u5b9a\uff0c\u986f\u793aD3S-001\u53ef\u80fd\u80fd\u5920\u7a7f\u900f\u8840\u8166\u5c4f\u969c<a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a>\uff0c\u6ef2\u900f\u81f3\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u767c\u63ee\u7642\u6548\u3002\u53e6\u5916\uff0c\u5718\u968a\u901a\u904e\u8840\u6db2\u6aa2\u6e2c\u767c\u73fe\uff0c\u60a3\u8005\u5982\u679c\u5728\u6cbb\u7642\u5f8c\u7684KRAS-G12C\u7684\u7a81\u8b8a\u7b49\u4f4d\u57fa\u56e0\u983b\u7387\uff08mutant allele frequency, 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