{"id":132665,"date":"2022-10-24T16:48:47","date_gmt":"2022-10-24T08:48:47","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/?post_type=press&p=132665"},"modified":"2022-10-24T16:48:44","modified_gmt":"2022-10-24T08:48:44","slug":"large-scale-clinical-study-shows-cu-medicine-sim01-microbiome-formula-reduces-risk-of-infections-including-covid-19","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/large-scale-clinical-study-shows-cu-medicine-sim01-microbiome-formula-reduces-risk-of-infections-including-covid-19\/","title":{"rendered":"\u5927\u578b\u81e8\u5e8a\u7814\u7a76\u8b49\u4e2d\u5927\u8178\u9053\u5fae\u751f\u614b\u914d\u65b9 (SIM01) \u80fd\u6e1b\u65b0\u51a0\u53ca\u5176\u4ed6\u7d30\u83cc\u548c\u75c5\u6bd2\u611f\u67d3\u98a8\u96aa"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-132665","press","type-press","status-publish","hentry"],"acf":{"title_alt":"","sub_title_alt":"","press_date":"20221024","keep":false,"details":"

\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u9032\u884c\u5927\u578b\u81e8\u5e8a\u96d9\u76f2\u7814\u7a76\uff0c\u767c\u73fe\u4e0d\u8ad6\u662f\u63a5\u7a2e\u79d1\u8208\u6216\u5fa9\u5fc5\u6cf0\u65b0\u51a0\u75ab\u82d7\uff0c\u5176\u7814\u767c\u7684\u5fae\u751f\u614b\u914d\u65b9 SIM01\u90fd\u80fd\u5920\u6e1b\u4f4e\u9577\u8005\u53ca\u7cd6\u5c3f\u75c5\u60a3\u8005\u7b49\u9ad8\u5371\u4e00\u65cf\u5728\u63a5\u7a2e\u75ab\u82d7\u5f8c\u51fa\u73fe\u7684\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u3002\u5718\u968a\u66f4\u9996\u6b21\u767c\u73fe\u670d\u7528SIM01 \u7684\u7d44\u522b\u6bd4\u8f03\u5c0d\u7167\u7d44\u6e1b\u5c11\u4e86\u7d30\u83cc\u548c\u75c5\u6bd2\u611f\u67d3\u7684\u98a8\u96aa\uff08\u5305\u62ec\u767c\u71d2\u3001\u76ae\u819a\u708e\u3001\u6557\u8840\u75c5\u548c\u65b0\u51a0\u80ba\u708e\u7b49\uff09\u3002\u7814\u7a76\u5718\u968a\u9032\u4e00\u6b65\u4ee5\u5b8f\u57fa\u56e0\u7d44\u5b78\u6e2c\u5e8f\uff08Shotgun metagenomic sequencing\uff09\u5206\u6790\uff0c\u8b49\u5be6SIM01\u53ef\u4ee5\u91cd\u5851\u5065\u5eb7\u7684\u8178\u9053\u5fae\u751f\u614b\uff0c\u63d0\u5347\u6574\u9ad4\u5065\u5eb7\u6c34\u5e73\u3002\u662f\u9805\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0cSIM01\u900f\u904e\u6539\u5584\u8178\u9053\u5fae\u751f\u614b\uff0c\u63d0\u5347\u514d\u75ab\u529b\u4ee5\u5c0d\u6297\u7d30\u83cc\u53ca\u75c5\u6bd2\u5165\u4fb5\u3002<\/p>\r\n

SIM01\u5fae\u751f\u614b\u914d\u65b9\u80fd\u91cd\u5851\u5065\u5eb7\u7684\u8178\u9053\u5fae\u751f\u614b<\/strong><\/p>\r\n

\u4e2d\u5927\u91ab\u5b78\u9662\u65e9\u524d\u7814\u7a76\u6307\u51fa\uff0c\u4e0d\u5065\u5eb7\u7684\u8178\u9053\u5fae\u751f\u614b\u8207\u65b0\u51a0\u75c5\u6bd2\u75c5\u4f75\u767c\u75c7\u7684\u56b4\u91cd\u7a0b\u5ea6\u606f\u606f\u76f8\u95dc\uff0c\u4e26\u8b49\u5be6\u5229\u7528\u5176\u7814\u767c\u7684\u5fae\u751f\u614b\u914d\u65b9SIM01\u80fd\u6539\u5584\u60a3\u8005\u7684\u5fb5\u72c0\u3002\u7814\u7a76\u5718\u968a\u53e6\u6e2c\u8a66\u5df2\u63a5\u7a2e\u65b0\u51a0\u75ab\u82d7\u4eba\u58eb\u7684\u8840\u6db2\u6a23\u672c\uff0c\u767c\u73fe\u5229\u7528SIM01\u80fd\u5920\u6709\u6548\u964d\u4f4e\u63a5\u7a2e\u75ab\u82d7\u5f8c\u7684\u767c\u708e\u6307\u6578\uff0c\u540c\u6642\u53ef\u63d0\u5347\u5c0d\u6297\u75c5\u6bd2\u7684\u6297\u9ad4\u6c34\u5e73\u3002<\/p>\r\n

\u70ba\u9032\u4e00\u6b65\u4e86\u89e3SIM01\u5c0d\u9ad8\u5371\u4e00\u65cf\u7684\u6548\u7528\uff0c\u4e2d\u5927\u91ab\u5b78\u9662\u57282021\u81f32022\u5e74\u9593\u5171\u62db\u52df\u4e86453\u4f4d\u9577\u671f\u75c5\u60a3\u8005\u53ca65\u6b72\u6216\u4ee5\u4e0a\u4eba\u58eb\u53c3\u8207\u7814\u7a76\u3002\u53c3\u52a0\u8005\u5728\u53c3\u8207\u7814\u7a76\u524d\u6216\u5f8c\u4e00\u661f\u671f\u5167\u63a5\u53d7\u7b2c\u4e00\u5291\u65b0\u51a0\u75ab\u82d7\uff0c\u4e26\u96a8\u6a5f\u5206\u914d\u670d\u7528\u70ba\u671f\u4e09\u500b\u6708\u7684\u5fae\u751f\u614b\u914d\u65b9SIM01\uff0c\u6216\u542b\u6709\u7dad\u4ed6\u547dC\u7684\u5b89\u6170\u5291\uff08\u5c0d\u7167\u7d44\uff09\uff0c\u5169\u8005\u4eba\u6578\u5404\u4f54\u7d04\u4e00\u534a\u3002<\/p>\r\n

\u4e2d\u5927\u91ab\u5b78\u9662\u5185\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u52a9\u7406\u6559\u6388\u5f35\u7433\u6559\u6388<\/strong>\u8868\u793a\uff1a\u300c\u662f\u6b21\u7814\u7a76\u63a1\u7528\u4e86\u56b4\u683c\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\u7684\u8a2d\u8a08\uff0c\u4e26\u4ee5\u7cbe\u6e96\u7684\u5b8f\u57fa\u56e0\u7d44\u5b78\u5206\u6790\uff0c\u65e8\u5728\u8a55\u4f30SIM01 \u80fd\u5426\u6062\u5fa9\u5065\u5eb7\u7684\u8178\u9053\u5fae\u751f\u614b\u53ca\u63d0\u5347\u514d\u75ab\u529b\u4ee5\u62b5\u79a6\u7d30\u83cc\u548c\u75c5\u6bd2\u611f\u67d3\u7684\u6548\u679c\u3002\u300d<\/p>\r\n

SIM01\u53ef\u6301\u7e8c\u6e1b\u5c11\u75ab\u82d7\u4e0d\u826f\u53cd\u61c9\u53ca\u6539\u5584\u5065\u5eb7\u8cea\u7d20<\/strong><\/p>\r\n

\u7d50\u679c\u767c\u73fe\uff0c\u670d\u7528\u5fae\u751f\u614b\u914d\u65b9SIM01\u7684\u53c3\u52a0\u8005\u5728\u63a5\u7a2e\u7b2c\u4e8c\u5291\u65b0\u51a0\u75ab\u82d7\u4e00\u500b\u6708\u5f8c\uff0c\u51fa\u73fe\u4e0d\u826f\u53cd\u61c9\u7684\u6bd4\u7387 \uff082.9%\uff09 \u8f03\u5c0d\u7167\u7d44 \uff0812.6%\uff09 \u70ba\u4f4e\u3002\u7121\u8ad6\u662f\u63a5\u7a2e\u54ea\u6b3e\u75ab\u82d7\uff0c\u670d\u7528SIM01\u7684\u53c3\u52a0\u8005\u5728\u7b2c\u4e09\u500b\u6708 \uff080% vs. 3.1%\uff09\u3001\u7b2c\u516d\u500b\u6708\uff086.2% vs. 16.9%\uff09\u3001\u53ca\u7b2c\u5341\u4e8c\u500b\u6708\uff085.4% vs. 17.8%\uff09 \u51fa\u73fe\u4e0d\u826f\u53cd\u61c9\u7684\u6bd4\u7387\u4ea6\u6301\u7e8c\u8f03\u5c0d\u7167\u7d44\u4f4e\u3002\u76f8\u6bd4\u5c0d\u7167\u7d44\uff0c\u7814\u7a76\u4ea6\u767c\u73feSIM01\u7d44\u522b\u7684\u53c3\u52a0\u8005\u6709\u8f03\u597d\u7684\u7761\u7720\u8cea\u7d20 \uff0841.4% vs. 19.3%\uff09 \u3001\u8f03\u6b63\u9762\u7684\u60c5\u7dd2 \uff0821.1% vs. 11.4%\uff09 \u53ca\u76ae\u819a\u8cea\u7d20\u6709\u6240\u6539\u5584\uff0814.1% vs 7.0%\uff09\u3002<\/p>\r\n

SIM01\u914d\u65b9\u6e1b\u5c11\u65b0\u51a0\u53ca\u5176\u4ed6\u611f\u67d3\u7684\u98a8\u96aa<\/strong><\/p>\r\n

\u5718\u968a\u53e6\u4e00\u500b\u5275\u65b0\u767c\u73fe\uff0c\u5c31\u662f\u670d\u7528\u5fae\u751f\u614b\u914d\u65b9SIM01\u7684\u7d44\u522b\u60a3\u4e0a\u65b0\u51a0\u75c5\u6bd2\u53ca\u5176\u4ed6\u7d30\u83cc\u548c\u75c5\u6bd2\u611f\u67d3 \uff08\u5305\u62ec\u76ae\u819a\u708e\u3001\u6557\u8840\u75c5\u3001\u548c\u50b7\u53e3\u611f\u67d3\uff09\u7684\u98a8\u96aa\u660e\u986f\u8f03\u5c0d\u7167\u7d44\u4f4e \uff08\u7b2c\u4e00\u500b\u6708: 0.5% vs. 5.6%; \u7b2c\u4e09\u500b\u6708: 0% vs. 0.6%; \u7b2c\u516d\u500b\u6708: 4.8% vs 15.5%; \u7b2c\u5341\u4e8c\u500b\u6708: 5.4% vs. 14.4%\uff09\uff0c\u986f\u793aSIM01\u53ef\u4ee5\u63d0\u5347\u514d\u75ab\u529b\u5c0d\u6297\u5176\u4ed6\u7d30\u83cc\u548c\u75c5\u6bd2\u611f\u67d3\u3002<\/p>\r\n

\u4e2d\u5927\u91ab\u5b78\u9662\u8cfd\u99ac\u6703\u516c\u5171\u885e\u751f\u53ca\u57fa\u5c64\u91ab\u7642\u5b78\u9662\u9ec3\u81f3\u751f\u6559\u6388<\/strong>\u6307\u51fa\uff1a\u300c\u4e0d\u5c11\u9577\u8005\u3001\u5152\u7ae5\u53ca\u9577\u671f\u75c5\u60a3\u8005\u4ecd\u7136\u6182\u616e\u65b0\u51a0\u75ab\u82d7\u53ef\u80fd\u7522\u751f\u7684\u526f\u4f5c\u7528\u3002\u8207\u6b64\u518d\u6642\uff0c\u5728\u75ab\u60c5\u5927\u6d41\u884c\u4e2d\uff0c\u5982\u4f55\u6709\u6548\u63d0\u5347\u9019\u4e9b\u9ad8\u5371\u4e00\u65cf\u7684\u514d\u75ab\u529b\u53bb\u5c0d\u6297\u5404\u7a2e\u50b3\u67d3\u75c5\uff0c\u4ea6\u662f\u5927\u773e\u95dc\u5fc3\u7684\u91cd\u9ede\u3002\u662f\u9805\u5927\u578b\u81e8\u5e8a\u96d9\u76f2\u7814\u7a76\u8b49\u5be6SIM01\u6709\u6548\u6e1b\u4f4e\u65b0\u51a0\u53ca\u5176\u4ed6\u7d30\u83cc\u548c\u75c5\u6bd2\u611f\u67d3\u7684\u98a8\u96aa\uff0c\u5305\u62ec\u6557\u8840\u75c5\u7b49\u3002\u7814\u7a76\u7d50\u679c\u6b63\u597d\u56de\u61c9\u793e\u6703\u7684\u9700\u8981\uff0c\u5c24\u5176\u662f\u9577\u8005\u53ca\u9577\u671f\u75c5\u60a3\u8005\u7b49\u514d\u75ab\u529b\u8f03\u5f31\u4eba\u58eb\u3002\u300d<\/p>\r\n

\u91cd\u5851\u5065\u5eb7\u7684\u8178\u9053\u5fae\u751f\u614b\u5c0d\u6297\u611f\u67d3<\/strong><\/p>\r\n

\u7814\u7a76\u5718\u968a\u4ee5\u5b8f\u57fa\u56e0\u7d44\u5b78(Metagenomics)\uff0c\u5206\u6790283\u4f4d\u670d\u7528\u4e09\u500b\u6708\u5fae\u751f\u614bSIM01 \u6216\u5b89\u6170\u5291\u7684\u5e02\u6c11\u7684\u7cde\u4fbf\u6a23\u672c\uff0c\u4ee5\u8a55\u4f30\u4ed6\u5011\u8178\u9053\u5fae\u751f\u614b\u7684\u6539\u8b8a\u3002\u7d50\u679c\u986f\u793a\u53c3\u52a0\u8005\u5728\u670d\u7528\u4e09\u500b\u6708SIM01\u914d\u65b9\u5f8c\uff0c\u8178\u9053\u83cc\u7fa4\u4e2d\u8a31\u591a\u76ca\u83cc\u7684\u6578\u91cf\u6709\u986f\u8457\u63d0\u5347 \uff0c\u4e26\u540c\u6642\u964d\u4f4e\u4e86\u591a\u7a2e\u60e1\u83cc\u7684\u542b\u91cf\uff0c\u986f\u793aSIM01\u914d\u65b9\u53ef\u91cd\u5851\u5065\u5eb7\u7684\u8178\u9053\u5fae\u751f\u614b\u3002\u00a0<\/p>\r\n

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