{"id":120760,"date":"2021-11-26T09:17:02","date_gmt":"2021-11-26T01:17:02","guid":{"rendered":"https:\/\/www.cpr.cuhk.edu.hk\/?post_type=press&#038;p=120760"},"modified":"2021-12-01T16:57:00","modified_gmt":"2021-12-01T08:57:00","slug":"cuhk-study-sheds-light-on-novel-mechanism-and-treatment-of-acute-kidney-injury-in-covid-19-patients","status":"publish","type":"press","link":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/press\/cuhk-study-sheds-light-on-novel-mechanism-and-treatment-of-acute-kidney-injury-in-covid-19-patients\/","title":{"rendered":"\u4e2d\u5927\u7814\u7a76\u63ed\u793a\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u6025\u6027\u814e\u640d\u50b7\u7684\u65b0\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","tags":[],"class_list":["post-120760","press","type-press","status-publish","hentry"],"acf":{"title_alt":"","sub_title_alt":"","press_date":"20211129","keep":false,"details":"<p>\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u91ab\u5b78\u9662\u8fd1\u65e5\u4e00\u9805\u7814\u7a76\u767c\u73fe\uff0c\u65b0\u51a0\u75c5\u6bd2\u7684\u6838\u6bbc\u86cb\u767d\uff08N\u86cb\u767d\uff09\u53ef\u8a98\u767c\u6025\u6027\u814e\u640d\u50b7\u3002\u4e2d\u5927\u91ab\u5b78\u9662\u7814\u7a76\u5718\u968a\u7d93\u5c0f\u9f20\u5be6\u9a57\u8b49\u5be6\uff0c\u65b0\u51a0\u75c5\u6bd2\u7684N\u86cb\u767d\u5177\u81f4\u75c5\u6027\uff0c\u53ef\u8207\u8f49\u5316\u751f\u9577\u56e0\u5b50-\u03b21\uff08TGF-\u03b21\uff09\u4fe1\u865f\u5206\u5b50Smad3\u7522\u751f\u76f8\u4e92\u4f5c\u7528\uff0c\u5f15\u81f4\u814e\u5c0f\u7ba1\u4e0a\u76ae\u7d30\u80de\u6b7b\u4ea1\uff0c\u76f4\u63a5\u9020\u6210\u6025\u6027\u814e\u640d\u50b7\u3002\u9032\u4e00\u6b65\u7684\u5be6\u9a57\u8b49\u660e\uff0c\u5229\u7528\u57fa\u56e0\u6572\u9664\u6280\u8853\u6216\u85e5\u7269\u6291\u5236Smad3\u80fd\u5920\u963b\u6b62\u65b0\u51a0\u75c5\u6bd2N\u86cb\u767d\u9020\u6210\u7684\u6025\u6027\u814e\u640d\u50b7\uff0c\u63ed\u793aSmad3\u6291\u5236\u5291\u6216\u53ef\u6210\u70ba\u6cbb\u7642\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u6025\u6027\u814e\u640d\u50b7\u7684\u65b0\u65b9\u6cd5\u3002\u7814\u7a76\u7d50\u679c\u525b\u5728\u570b\u969b\u671f\u520a\u300a<strong><em>Advanced Science<\/em><\/strong>\u300b\u767c\u8868\u3002<\/p>\r\n<p><strong>\u63a5\u53d7\u6df1\u5207\u6cbb\u7642\u7684\u65b0\u51a0\u80ba\u708e\u75c5\u4eba<\/strong> <strong>\u903e\u56db\u6210\u51fa\u73fe\u6025\u6027\u814e\u640d\u50b7<\/strong><\/p>\r\n<p>\u6025\u6027\u814e\u640d\u50b7\u5e38\u898b\u65bc\u75c5\u60c5\u5371\u91cd\u7684\u65b0\u51a0\u80ba\u708e\u60a3\u8005\uff0c\u5176\u7279\u5fb5\u5305\u62ec\u8840\u6e05\u808c\u9150\u6c34\u5e73\u4e0a\u5347\u3001\u814e\u5c0f\u7ba1\u58de\u6b7b\u53ca\u814e\u81df\u767c\u708e\u3002\u6b64\u75c7\u7684\u767c\u751f\u7387\u8207\u65b0\u51a0\u80ba\u708e\u75c5\u60c5\u56b4\u91cd\u7a0b\u5ea6\uff0c\u4ee5\u53ca\u60a3\u8005\u81ea\u8eab\u6709\u5426\u6f5b\u5728\u75be\u75c5\u606f\u606f\u76f8\u95dc\u3002\u6839\u64da\u5df2\u767c\u8868\u7684\u6578\u64da\uff0c\u7559\u91ab\u6df1\u5207\u6cbb\u7642\u90e8\u7684\u91cd\u75c7\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u4e2d\uff0c\u8d85\u904e40%\u6703\u51fa\u73fe\u6025\u6027\u814e\u640d\u50b7\uff0c\u800c\u4e14\u6b7b\u4ea1\u7387\u5f88\u9ad8\u3002\u53e6\u6709\u7814\u7a76\u6307\u51fa\uff0c\u6025\u6027\u814e\u640d\u50b7\u662f\u7e7c\u6025\u6027\u547c\u5438\u8870\u7aed\u5f8c\uff0c\u5728\u65b0\u51a0\u80ba\u708e\u5371\u91cd\u60a3\u8005\u4e2d\u70ba\u7b2c\u4e8c\u5e38\u898b\u7684\u4f75\u767c\u75c7\u3002<\/p>\r\n<p>\u73fe\u6642\u5df2\u77e5\u65b0\u51a0\u75c5\u6bd2\u662f\u900f\u904e\u5176\u523a\u7a81\u86cb\u767d\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\uff0c\u4f46\u75c5\u6bd2\u5728\u6025\u6027\u814e\u640d\u50b7\u4e2d\u5f15\u767c\u7d30\u80de\u6b7b\u4ea1\u7684\u6a5f\u5236\u5c1a\u672a\u6e05\u6670\u3002<\/p>\r\n<p>\u4e2d\u5927\u91ab\u5b78\u9662\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb<strong>\u738b\u6587\u6a19\u535a\u58eb<\/strong>\u548c<strong>\u9673\u4fca\u54f2\u535a\u58eb<\/strong>\u662f\u8a72\u7814\u7a76\u8ad6\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002\u4ed6\u5011\u6307\u51fa\uff0c\u814e\u81df\u662f\u65b0\u51a0\u60a3\u8005\u53d7\u5f71\u97ff\u7684\u4e3b\u8981\u5668\u5b98\u4e4b\u4e00\uff0c\u4f46\u73fe\u6642\u4e26\u6c92\u6709\u5177\u91dd\u5c0d\u6027\u517c\u6709\u6548\u7684\u6cbb\u7642\u3002\u56e0\u6b64\uff0c\u78ba\u5b9a\u65b0\u51a0\u75c5\u6bd2\u86cb\u767d\u5f15\u767c\u6025\u6027\u814e\u640d\u50b7\u7684\u7d30\u80de\u6b7b\u4ea1\u6a5f\u5236\u523b\u4e0d\u5bb9\u7de9\uff0c\u662f\u7814\u767c\u65b0\u6cbb\u7642\u65b9\u6848\u7684\u7b2c\u4e00\u6b65\u3002<\/p>\r\n<p><strong>\u8b49\u5be6\u65b0\u51a0\u75c5\u6bd2<\/strong><strong>N<\/strong><strong>\u86cb\u767d\u5177\u81f4\u75c5\u6027<\/strong> <strong>\u53ef\u8a98\u767c\u6025\u6027\u814e\u640d\u50b7<\/strong><\/p>\r\n<p>\u7814\u7a76\u5718\u968a\u900f\u904e\u5c0f\u9f20\u5be6\u9a57\u8b49\u5be6\u65b0\u51a0\u75c5\u6bd2N\u86cb\u767d\u5177\u81f4\u75c5\u6027\uff0c\u53ef\u901a\u904e\u5f15\u8d77\u814e\u5c0f\u7ba1\u58de\u6b7b\u548c\u8840\u6e05\u808c\u9150\u6c34\u5e73\u660e\u986f\u5347\u9ad8\uff0c\u8a98\u767c\u6025\u6027\u814e\u640d\u50b7\uff0c\u5728\u7f3a\u8840\u60c5\u6cc1\u4e0b\u5c24\u5176\u56b4\u91cd\u3002\u9019\u4e9b\u767c\u73fe\u8207\u81e8\u5e8a\u89c0\u5bdf\u7d50\u679c\u543b\u5408\uff0c\u5373\u662f\u6025\u6027\u814e\u640d\u50b7\u5728\u4e00\u822c\u65b0\u51a0\u80ba\u708e\u75c5\u4eba\u4e2d\u4e26\u4e0d\u592a\u56b4\u91cd\uff0c\u4f46\u5728\u672c\u8eab\u6709\u7f3a\u8840\u6027\u548c\u708e\u75c7\u6027\u75be\u75c5\u7684\u60a3\u8005\u8eab\u4e0a\uff0c\u60c5\u6cc1\u4fbf\u6703\u60e1\u5316\u3002<\/p>\r\n<p>\u6b64\u5916\uff0c\u7814\u7a76\u5c0f\u7d44\u767c\u73fe\u65b0\u51a0\u75c5\u6bd2 N \u86cb\u767d\u901a\u904e\u8207Smad3\u7684\u4fe1\u865f\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\uff0c\u6fc0\u6d3b\u7d30\u80de\u6b7b\u4ea1\u9014\u5f91\uff0c\u76f4\u63a5\u8a98\u767c\u6025\u6027\u814e\u640d\u50b7\u3002\u7576\u8f49\u5316\u751f\u9577\u56e0\u5b50-\u03b21\uff08TGF-\u03b21\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684Smad3\u88ab\u6fc0\u6d3b\uff0c\u4fbf\u53ef\u555f\u52d5\u7d30\u80de\u5185\u6b7b\u4ea1\u901a\u9053\uff0c\u5c0e\u81f4\u814e\u5c0f\u7ba1\u4e0a\u76ae\u7d30\u80de\u6b7b\u4ea1\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u7814\u7a76\u5718\u968a\u8b49\u660e\uff0c\u5229\u7528\u57fa\u56e0\u6572\u9664\u6280\u8853\u6216\u85e5\u7269\u6291\u5236Smad3\uff0c\u5747\u53ef\u9632\u6b62\u7531Smad3\u5f15\u767c\u7684\u7d30\u80de\u6b7b\u4ea1\u53ca\u6025\u6027\u814e\u640d\u50b7\u3002\u56e0\u6b64\uff0c\u4ee5Smad3\u4f5c\u70ba\u6291\u5236\u9776\u9ede\u6709\u671b\u6210\u70ba\u4e00\u7a2e\u5d84\u65b0\u6cbb\u7642\u65b0\u51a0\u80ba\u708e\u6025\u6027\u814e\u640d\u50b7\u7684\u65b9\u6cd5\u3002<\/p>\r\n<p>\u9818\u5c0e\u8a72\u9805\u7814\u7a76\u7684\u4e2d\u5927\u91ab\u5b78\u9662\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u5353\u654f\u751f\u7269\u91ab\u5b78\u7814\u7a76\u6559\u6388<strong>\u85cd\u8f1d\u8000\u6559\u6388<\/strong>\u7e3d\u7d50\uff1a\u300c\u6211\u5011\u7684\u7814\u7a76\u5718\u968a\u65e9\u524d\u5df2\u767c\u73feTGF-\u03b2\/Smad3\u4fe1\u865f\u50b3\u5c0e\u662f\u5c0e\u81f4\u7d44\u7e54\u7e96\u7dad\u5316\u7684\u95dc\u9375\u9014\u5f91\u3002\u6839\u64da\u6211\u5011\u6700\u65b0\u7684\u5be6\u9a57\u7d50\u679c\uff0c\u65b0\u51a0\u75c5\u6bd2N\u86cb\u767d\u53ef\u4ee5\u8207Smad3\u7522\u751f\u76f8\u4e92\u4f5c\u7528\uff0c\u5c0e\u81f4\u65b0\u51a0\u80ba\u708e\u5371\u91cd\u60a3\u8005\u6025\u6027\u814e\u640d\u50b7\uff0c\u751a\u81f3\u6709\u6a5f\u6703\u6f14\u8b8a\u6210\u5668\u5b98\u7e96\u7dad\u5316\uff0c\u5982\u80ba\u7e96\u7dad\u5316\u3002\u56e0\u6b64\uff0c\u9776\u5411Smad3\u4e0d\u50c5\u80fd\u5920\u6291\u5236\u6025\u6027\u814e\u640d\u50b7\uff0c\u66f4\u53ef\u6210\u70ba\u65b0\u51a0\u80ba\u708e\u76f8\u95dc\u5668\u5b98\u7e96\u7dad\u5316\u7684\u65b0\u6cbb\u7642\u7b56\u7565\uff0c\u70ba\u964d\u4f4e\u65b0\u51a0\u80ba\u708e\u5668\u5b98\u640d\u50b7\u7684\u56b4\u91cd\u7a0b\u5ea6\u5e36\u4f86\u5e0c\u671b\u3002\u300d<\/p>\r\n<p>\u9019\u9805\u7814\u7a76\u7372\u5f97\u9999\u6e2f\u7814\u7a76\u8cc7\u52a9\u5c40\uff0814101121\uff09\u3001\u7cb5\u6e2f\u6fb3\u6162\u6027\u814e\u75c5\u514d\u75ab\u8207\u907a\u50b3\u7814\u7a76\u806f\u5408\u5be6\u9a57\u5ba4\u8a08\u5283\uff082019B121205005\uff09\u3001\u5442\u5fd7\u548c\u5275\u65b0\u91ab\u5b78\u7814\u7a76\u6240\uff08\u5fc3\u8840\u7ba1\u767c\u5c55\u3001\u7814\u7a76\u548c\u6559\u80b2\u8a08\u5283\uff09\u3001\u9999\u6c5f\u5b78\u8005\u8a08\u5283\uff08XJ2019052)\uff0c\u4ee5\u53ca\u570b\u5bb6\u81ea\u7136\u79d1\u5b78\u57fa\u91d1\u59d4\u54e1\u6703\uff0881902053)\u7684\u652f\u6301\u3002\u7814\u7a76\u8a73\u60c5\u53ef\u700f\u89bd\uff1a<a href=\"https:\/\/doi.org\/10.1002\/advs.202103248\">https:\/\/doi.org\/10.1002\/advs.202103248<\/a>\u3002<\/p>","show_as_achievement":true,"achievement_category":["staff"],"show_as_clarification":false,"show_as_announcement":false,"photos":[{"photo":120941,"caption":"\u85cd\u8f1d\u8000\u6559\u6388"},{"photo":120942,"caption":"\u9673\u4fca\u54f2\u535a\u58eb"},{"photo":120943,"caption":"\u738b\u6587\u6a19\u535a\u58eb"}],"attachments":null,"video_source":"","video_file":"","add_play_button":false,"video_caption":"","show_migration":false,"original_id":0,"photos_original":null,"attachments_original":null},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/120760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press"}],"about":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/types\/press"}],"version-history":[{"count":9,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/120760\/revisions"}],"predecessor-version":[{"id":120999,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/press\/120760\/revisions\/120999"}],"wp:attachment":[{"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/media?parent=120760"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cpr.cuhk.edu.hk\/sc\/wp-json\/wp\/v2\/tags?post=120760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}