\u7b2c\u4e03\u5c46\u9999\u6e2f\u5927\u5b78\u751f\u5275\u65b0\u53ca\u5275\u696d\u5927\u8cfd\u65e5\u524d\u65bc\u9999\u6e2f\u79d1\u5b78\u5712\u5713\u6eff\u8209\u884c\u3002\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\uff08\u4e2d\u5927\uff09\u5b78\u751f\u5728\u6bd4\u8cfd\u4e2d\u8868\u6f14\u51fa\u8272\uff0c\u8d0f\u5f9715\u500b\u734e\u9805\uff0c\u5305\u62ec\u5275\u65b0\u7d44\u5225\u5169\u500b\u4e00\u7b49\u734e\u3001\u5169\u500b\u4e8c\u7b49\u734e\u3001\u4e94\u500b\u4e09\u7b49\u734e\u53ca\u4e09\u500b\u512a\u7570\u734e\uff0c\u4ee5\u53ca\u5275\u696d\u7d44\u5225\u4e00\u500b\u4e09\u7b49\u734e\u53ca\u5169\u500b\u512a\u7570\u734e\u3002<\/p>\r\n
\u5927\u8cfd\u7531\u9999\u6e2f\u65b0\u4e00\u4ee3\u6587\u5316\u5354\u6703\u8209\u8fa6\uff0c\u7372\u734e\u7684\u9999\u6e2f\u5340\u5275\u65b0\u9805\u76ee\u5c07\u4ee3\u8868\u9999\u6e2f\u53c3\u8207\u300c\u6311\u6230\u76c3\u2014\u5168\u570b\u5927\u5b78\u751f\u8ab2\u5916\u5b78\u8853\u79d1\u6280\u4f5c\u54c1\u7af6\u8cfd\u300d\uff0c\u800c\u5275\u696d\u9805\u76ee\u7684\u512a\u52dd\u968a\u4f0d\u5c07\u51fa\u7dda\u53c3\u8207\u300c\u4e2d\u570b\u570b\u969b\u4e92\u806f\u7db2+\u5927\u5b78\u751f\u5275\u65b0\u5275\u696d\u5927\u8cfd\u300d\u53ca\u300c\u6311\u6230\u76c3\uff08\u5275\u9752\u6625\uff09\u4e2d\u570b\u5927\u5b78\u751f\u5275\u696d\u8a08\u5283\u7af6\u8cfd\u300d\u3002<\/p>\r\n
\u662f\u6b21\u596a\u5f97\u4e00\u7b49\u734e\u7684\u5169\u500b\u4e2d\u5927\u9805\u76ee\u70ba\u5275\u65b0\u7d44\u5225\u7684\u300c\u958b\u767c\u4e00\u7a2e\u57fa\u65bc\u4e2d\u6027\u7c92\u7d30\u80de\u7684\u65b0\u578b\u6297\u764c\u514d\u75ab\u7642\u6cd5\uff1aS3KO-TAN\u300d\u53ca\u300c\u72f9\u7a84\u7a7a\u9593\u5167\u7684\u5fae\u578b\u6a5f\u5668\u4eba\u53ef\u5f4e\u66f2\u9aa8\u79d1\u624b\u8853\u947d\u300d\u3002<\/p>\r\n
\u5275\u65b0\u7d44\u5225\u4e00\u7b49\u734e\uff1a\u958b\u767c\u4e00\u7a2e\u57fa\u790e\u65bc\u4e2d\u6027\u7c92\u7d30\u80de\u7684\u65b0\u578b\u6297\u764c\u514d\u75ab\u7642\u6cd5\uff1a<\/strong>S3KO-TAN<\/strong><\/p>\r\n \u764c\u75c7\u662f\u5c0e\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\uff0c\u7531\u65bc\u764c\u7d30\u80de\u7684\u9ad8\u8b8a\u7570\u6027\uff0c\u5728\u5e38\u898f\u6cbb\u7642\u4e0b\u5bb9\u6613\u7522\u751f\u6297\u85e5\u6027\u3002\u6700\u65b0\u7684\u514d\u75ab\u7642\u6cd5\u96d6\u7136\u80fd\u5c0d\u6297\u764c\u75c7\uff0c\u4f46\u53ea\u5c0d\u4e0d\u8db3\u4e09\u6210\u7684\u80ba\u764c\u75c5\u4eba\u6709\u660e\u986f\u6548\u679c\u3002\u6709\u898b\u53ca\u6b64\uff0c\u75c5\u7406\u89e3\u5256\u53ca\u7d30\u80de\u5b78\u7cfb\u535a\u58eb\u7814\u7a76\u751f\u937e\u4e00\u743f<\/strong>\u53ca\u78a9\u58eb\u7814\u7a76\u751f\u9673\u91d1\u5764<\/strong>\u5728\u8a72\u5b78\u7cfb\u52a9\u7406\u6559\u6388\u9127\u9298\u6b0a\u6559\u6388<\/strong>\u7684\u6307\u5c0e\u4e0b\uff0c\u7814\u767c\u51fa\u4e00\u7a2e\u65b0\u578b\u6297\u764c\u514d\u75ab\u7642\u6cd5\uff0c\u4e26\u6210\u529f\u901a\u904e\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u8840\u6db2\u4e2d\u6700\u8c50\u5bcc\u7684\u514d\u75ab\u7d30\u80de\u2500\u2500\u55dc\u4e2d\u6027\u9846\u7c92\u7d30\u80de\u3002<\/p>\r\n \u8a72\u9805\u76ee\u5229\u7528\u6700\u65b0\u7684\u57fa\u56e0\u5de5\u7a0b\u6280\u8853CRISPR\/Cas9\u7de8\u8f2f\u4eba\u985e\u55dc\u4e2d\u6027\u9846\u7c92\u7d30\u80de\uff0c\u4ee5\u5927\u91cf\u751f\u7522\u65b0\u578b\u6297\u764c\u514d\u75ab\u6cbb\u7642\u5291S3KO-TAN\u3002\u55dc\u4e2d\u6027\u9846\u7c92\u7d30\u80de\u80fd\u76f4\u63a5\u61c9\u7528\u65bc\u7570\u9ad4\u79fb\u6b96\uff0c\u7121\u9700\u9032\u884c\u6297\u539f\u914d\u5c0d\uff0c\u4e26\u4e14\u5f88\u5bb9\u6613\u5f9e\u8840\u6db2\u526f\u7522\u54c1\u4e2d\u63d0\u53d6\uff0c\u986f\u8457\u5730\u514b\u670dT\u7d30\u80de\u514d\u75ab\u7642\u6cd5\u6240\u9762\u5c0d\u7684\u969c\u7919\u3002\u8a72\u7814\u7a76\u9805\u76ee\u7372\u5f97\u9999\u6e2f\u7814\u7a76\u8cc7\u52a9\u5c40\u3001\u8f49\u5316\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\u548c\u4e2d\u5927\u91ab\u5b78\u9662\u5275\u65b0\u734e\u7684\u652f\u6301\uff0c\u5718\u968a\u5e0c\u671b\u80fd\u65bc\u4e0d\u4e45\u5c07\u4f86\u8f49\u5316S3KO-TAN \u6210\u70ba\u4e00\u7a2e\u6709\u6548\u4e14\u5b89\u5168\u7684\u6297\u764c\u514d\u75ab\u7642\u6cd5\u3002<\/p>\r\n \u5275\u65b0\u7d44\u5225\u4e00\u7b49\u734e\uff1a\u72f9\u7a84\u7a7a\u9593\u5167\u7684\u5fae\u578b\u6a5f\u5668\u4eba\u53ef\u5f4e\u66f2\u9aa8\u79d1\u624b\u8853\u947d<\/strong><\/p>\r\n \u4eba\u9ad4\u7684\u7d44\u7e54\u7d50\u69cb\u8907\u96dc\uff0c\u5728\u9032\u884c\u50b3\u7d71\u7684\u9aa8\u79d1\u624b\u8853\u6642\uff0c\u91ab\u751f\u9700\u8981\u53bb\u9664\u5927\u91cf\u5065\u5eb7\u7684\u7d44\u7e54\u624d\u80fd\u5c07\u7d50\u69cb\u786c\u76f4\u7684\u624b\u8853\u5de5\u5177\u4f38\u5230\u76ee\u6a19\u4f4d\u7f6e\uff0c\u4e0d\u4f46\u884d\u751f\u8853\u5f8c\u75bc\u75db\u548c\u4f75\u767c\u75c7\uff0c\u9084\u6703\u589e\u52a0\u75c5\u4eba\u7684\u4f4f\u9662\u548c\u5eb7\u5fa9\u6642\u9593\u3002\u4e2d\u5927\u6a5f\u68b0\u8207\u81ea\u52d5\u5316\u5de5\u7a0b\u5b78\u7cfb\u535a\u58eb\u7814\u7a76\u751f\u738b\u5ca9<\/strong>\u3001\u6797\u6d2a\u658c<\/strong>\u548c\u738b\u980a\u741b<\/strong>\u5728\u6b50\u570b\u5a01\u6559\u6388\u7684\u6307\u5c0e\u4e0b\u7814\u88fd\u4e86\u4e00\u7a2e\u53ef\u65bc\u72f9\u7a84\u7a7a\u9593\u5167\u5f4e\u66f2\u7684\u5fae\u578b\u624b\u8853\u947d\u982d\u3002\u5176\u5fae\u578b\u5c3a\u5bf8\uff084.5\u6beb\u7c73\u76f4\u5f91\uff09\u548c\u5927\u672b\u7aef\u5f4e\u66f2\u89d2\u5ea6\uff08\u00b165\u5ea6\uff09\u80fd\u4f7f\u5176\u901a\u904e\u5fae\u5c0f\u5275\u53e3\uff0c\u7e5e\u904e\u4eba\u9ad4\u90e8\u5206\u7d44\u7e54\u7d50\u69cb\u5230\u9054\u76ee\u6a19\u624b\u8853\u4f4d\u7f6e\uff0c\u4ee5\u6e1b\u5c0f\u5c0d\u75c5\u4eba\u7684\u50b7\u5bb3\u3002\u8a72\u53ef\u5f4e\u66f2\u947d\u982d\u53ef\u7528\u65bc\u8f15\u5de7\uff08200\u514b\uff09\u7684\u624b\u6301\u8a2d\u5099\uff0c\u6216\u5b89\u88dd\u5728\u6a5f\u68b0\u81c2\u4e0a\u4ee5\u5be6\u73fe\u66f4\u9ad8\u7684\u7cbe\u5ea6\uff0c\u5728\u8033\u9f3b\u5589\u3001\u9871\u5e95\u548c\u810a\u67f1\u624b\u8853\u4e0a\u6709\u5f88\u5927\u7684\u61c9\u7528\u6f5b\u529b\u3002\u6b64\u767c\u660e\u4ea6\u65bc2021\u9ad8\u9315\u6559\u6388\u5b78\u751f\u5275\u610f\u734e\u596a\u5f97\u7814\u7a76\u751f\u7d44\u4e9e\u8ecd\u3002<\/p>\r\n \u4e2d\u5927\u5f97\u734e\u9805\u76ee\u540d\u55ae\uff1a<\/p>\r\n \u7d44\u5225<\/strong><\/p>\r\n<\/td>\r\n \u734e\u9805<\/strong><\/p>\r\n<\/td>\r\n \u9805\u76ee\u540d\u7a31<\/strong><\/p>\r\n<\/td>\r\n \u53c3\u8207\u5b78\u751f<\/strong><\/p>\r\n<\/td>\r\n \u6240\u5c6c\u5b78\u7cfb<\/strong><\/p>\r\n<\/td>\r\n<\/tr>\r\n \u5275\u65b0<\/strong><\/p>\r\n<\/td>\r\n \u4e00\u7b49<\/p>\r\n<\/td>\r\n \u958b\u767c\u4e00\u7a2e\u57fa\u790e\u65bc\u4e2d\u6027\u7c92\u7d30\u80de\u7684\u65b0\u578b\u6297\u764c\u514d\u75ab\u7642\u6cd5\uff1aS3KO-TAN<\/p>\r\n<\/td>\r\n \u937e\u4e00\u743f\u3001\u9673\u91d1\u5764<\/p>\r\n<\/td>\r\n \u75c5\u7406\u89e3\u5256\u53ca\u7d30\u80de\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n \u4e00\u7b49<\/p>\r\n<\/td>\r\n \u72f9\u7a84\u7a7a\u9593\u5167\u7684\u5fae\u578b\u6a5f\u5668\u4eba\u53ef\u5f4e\u66f2\u9aa8\u79d1\u624b\u8853\u947d<\/p>\r\n<\/td>\r\n \u738b\u5dd6\u3001\u6797\u6d2a\u658c\u3001\u738b\u980a\u741b<\/p>\r\n<\/td>\r\n \u6a5f\u68b0\u8207\u81ea\u52d5\u5316\u5de5\u7a0b\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n \u4e8c\u7b49<\/p>\r\n<\/td>\r\n \u91d1\u5c6c-\u914d\u9ad4\u81ea\u7d44\u88dd\u9ad8\u5ea6\u52d5\u614b\u7d0d\u7c73\u5fa9\u5408\u6c34\u51dd\u81a0<\/p>\r\n<\/td>\r\n \u82d1\u5049\u8c6a\u3001\u59da\u57f7\u3001\u52f5\u6649\u8b19\u3001\u90ed\u4f73\u6b23\u3001\u8463\u8afe\u8b19\u3001\u8a31\u9806\u7965<\/p>\r\n<\/td>\r\n \u751f\u7269\u91ab\u5b78\u5de5\u7a0b\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n \u4e8c\u7b49<\/p>\r\n<\/td>\r\n \u57fa\u65bc\u8d85\u8072\u7684\u91dd\u5c16\u81ea\u52d5\u8ddf\u8e64\u7cfb\u7d71<\/p>\r\n<\/td>\r\n \u56b4\u842c\u6cc9<\/p>\r\n<\/td>\r\n \u6a5f\u68b0\u8207\u81ea\u52d5\u5316\u5de5\u7a0b\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n \u4e09\u7b49<\/p>\r\n<\/td>\r\n \u808c\u795e\u7d93\u63a5\u5408\u9ede\u5728\u808c\u5c11\u75c7\u4e2d\u7684\u5f62\u614b\u7d50\u69cb\u53ca\u57fa\u56e0\u8b8a\u5316\u7814\u7a76<\/p>\r\n<\/td>\r\n \u5433\u8a60\u7147<\/p>\r\n<\/td>\r\n \u751f\u7269\u91ab\u5b78\u5de5\u7a0b\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n \u4e09\u7b49<\/p>\r\n<\/td>\r\n \u9632\u6382\u9762\u795e\u5668<\/p>\r\n<\/td>\r\n \u8b1d\u6587\u6615\u3001\u4f0d\u606c\u7469<\/p>\r\n<\/td>\r\n \u4fe1\u606f\u5de5\u7a0b\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n \u4e09\u7b49<\/p>\r\n<\/td>\r\n \u7232\u8eab\u969c\u4eba\u58eb\u800c\u8a2d\u8a08\u7684\u591a\u7528\u9014\u8edf\u6027\u6293\u6301\u624b\u81c2<\/p>\r\n<\/td>\r\n \u856d\u58eb\u658c\u3001\u9ec3\u5b50\u5609\u3001\u5f35\u7d20\u5152\u3001\u4f0d\u6c9b\u8ed2\u3001\u674e\u82b7\u6b23\u3001\u738b\u5029\u5100<\/p>\r\n<\/td>\r\n \u6a5f\u68b0\u8207\u81ea\u52d5\u5316\u5de5\u7a0b\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n \u4e09\u7b49<\/p>\r\n<\/td>\r\n \u6a5f\u5668\u4eba\u57fa\u65bc\u6fc0\u5149\u96f7\u9054\u548c\u8996\u89ba\u61c9\u7528\u7684\u901a\u7528\u6846\u67b6<\/p>\r\n<\/td>\r\n \u5289\u5eb7\u4e1e<\/p>\r\n<\/td>\r\n \u6a5f\u68b0\u8207\u81ea\u52d5\u5316\u5de5\u7a0b\u5b78\u7cfb<\/p>\r\n<\/td>\r\n<\/tr>\r\n 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